Silencing of the Long Non-Coding RNA TTN-AS1 Attenuates the Malignant Progression of Osteosarcoma Cells by Regulating the miR-16-1-3p/TFAP4 Axis

Meng, Xianghai; Zhang, Zhenjun; Chen, Lin; Wang, Xi; Zhang, Qingguo; Liu, Shuheng

doi:10.3389/fonc.2021.652835

Cited by 4 publications

(1 citation statement)

References 47 publications

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“…The intensity of IV collagenase burst in 1999 was 8.66 (1999-2005), indicating that IV collagenase is an earlier and more studied type of MMP in OS. Considering their high centrality, the invasion and migration may serve as a turning point and are also likely to develop into future research hotspots in MMP-OS ( 38 , 39 ).…”

Section: Discussionmentioning

confidence: 99%

Global scientific trends on matrix metalloproteinase and osteosarcoma: A bibliometric and visualized analysis

Ma²,

Wu³

et al. 2023

Front. Oncol.

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ObjectiveThis study aimed to identify author, country, institutional, and journal collaborations and their impacts, assess the knowledge base, identify existing trends, and uncover emerging topics related to the role of Metalloproteinase in osteosarcoma.Methods945 Articles and reviews associated with the role of Metalloproteinase in osteosarcoma were obtained from the WoSCC and analyzed by Citespace and Vosviewer.ResultsThe main aspects of research on the role of MMP in OS are invasion and metastasis. The latest hotspots were found to be the mechanism of MMP promoting invasion and metastasis, lung metastasis, and antitumor activity. Notably, invasion, metastasis, and antitumor activity were potentially turning points in the MMP-OS field. In the future, the primary research hotspot in the field of MMP-OS may be to study the mechanism, explore their role in the OS lung metastasis, and determine their role in the cancer therapy process.ConclusionThis study thus offers a comprehensive overview of the MMP-OS-related field using bibliometrics and visual methods, which will provide a valuable reference for researchers interested in the field of MMP-OS.

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Section: Discussionmentioning

confidence: 99%

Global scientific trends on matrix metalloproteinase and osteosarcoma: A bibliometric and visualized analysis

Ma²,

Wu³

et al. 2023

Front. Oncol.

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Prognostic significance of long noncoding RNA TTN‐AS1 in various malignancies

Lin,

Liu,

Cong

et al. 2023

Cancer Reports

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BackgroundIncreasing evidence has demonstrated that high TTN‐AS1 expression is highly related to poor prognosis in diverse human cancers. However, the findings concerning the prognostic value of TTN‐AS1 were inconsistent, as these conclusions were usually drawn with relatively small sample sizes. Hence, this meta‐analysis proposes to investigate the prognostic significance of TTN‐AS1 in multiple malignancies systematically.MethodsWeb of Science, Springer, Embase, PubMed, Cochrane Library, and Scopus databases were comprehensively searched to retrieve studies related to the TTN‐AS1 expression with the prognosis of malignancies. The significance of the TTN‐AS1 in cancers was estimated by hazard ratios (HRs) or odds ratios (ORs). Additionally, the Gene Expression Profiling Interactive Analysis (GEPIA) analysis tool was used to strengthen our results further.ResultsTwenty studies involving 17 different cancers and 1330 patients were recruited into this meta‐analysis. The research revealed that high TTN‐AS1 expression was remarkably associated with unfavorable overall survival (OS) (HR = 2.07, 95%CI [1.78, 2.41], p < .00001) when compared with low TTN‐AS1 expression in malignancies. Additionally, elevated TTN‐AS1 expression significantly contributed to lymph node metastasis (OR = 4.09, 95%CI [3.08, 5.44], p < .0001), larger tumor size (OR = 2.42, 95%CI [1.56, 3.77], p < .0001), worse tumor differentiation (OR = 0.36, 95%CI [0.22, 0.59], p < .0001) and more advanced tumor stage (OR = 0.29, 95%CI [0.22, 0.38], p < .0001) with low or no heterogeneity existing. Moreover, high TTN‐AS1 expression was connected with worse disease‐free survival in five different cancers based on the GEPIA online database.ConclusionsThe results of this meta‐analysis support that high TTN‐AS1 expression significantly correlates with worse prognosis in various cancers. Therefore, TTN‐AS1 may be considered as a novel biomarker for malignancies.

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TFAP4 Activates IGF2BP1 and Promotes Progression of Non–Small Cell Lung Cancer by Stabilizing TK1 Expression through m6A Modification

Shen

Sun

et al. 2022

Molecular Cancer Research

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Non-small cell lung cancer (NSCLC) is a well-known global health concern. TFAP4 has been reported to function as an oncogene. This study sought to investigate the molecular mechanism of TFAP4 in NSCLC development. Significantly highly-expressed gene IGF2BP1 was screened on online databases and its downstream gene TK1 was predicted. IGF2BP1 promoter sequence was identified. The binding site of TFAP4 and IGF2BP1 was predicted. The expression correlations among TFAP4, IGF2BP1, and TK1 were confirmed. The correlations between TFAP4, IGF2BP1, TK1, and NSCLC prognosis were predicted. NSCLC and paracancerous tissues were collected. The expressions of TFAP4, IGF2BP1, and TK1 were detected. NSCLC cell proliferation, migration, invasion, and apoptosis were detected. The binding of TFAP4 to the IGF2BP1 promoter was verified. m6A modification of TK1 mRNA was detected. The correlation between IGF2BP1 and TK1 was confirmed. A subcutaneous tumor xenograft model was established to validate the effect of TFAP4 in vivo. IGF2BP1 was highly expressed in NSCLC tissues and cells. IGF2BP1 knockdown repressed NSCLC cell proliferation, migration, and invasion and facilitated apoptosis. Mechanically, TFAP4 transcriptionally activated IGF2BP1. IGF2BP1 stabilized TK1 expression via m6A modification and promoted NSCLC cell proliferation, migration, and invasion. In vivo experiments confirmed that TFAP4 knockdown suppressed tumor growth by down-regulating IGF2BP1/TK1. Implications: Our findings revealed that TFAP4 activated IGF2BP1 and facilitated NSCLC progression by stabilizing TK1 expression via m6A modification, which offered new insights into the diagnosis and treatment of NSCLC.

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Silencing of the Long Non-Coding RNA TTN-AS1 Attenuates the Malignant Progression of Osteosarcoma Cells by Regulating the miR-16-1-3p/TFAP4 Axis

Cited by 4 publications

References 47 publications

Global scientific trends on matrix metalloproteinase and osteosarcoma: A bibliometric and visualized analysis

Global scientific trends on matrix metalloproteinase and osteosarcoma: A bibliometric and visualized analysis

Prognostic significance of long noncoding RNA TTN‐AS1 in various malignancies

TFAP4 Activates IGF2BP1 and Promotes Progression of Non–Small Cell Lung Cancer by Stabilizing TK1 Expression through m6A Modification

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