Silencing of long noncoding RNA UCA1 inhibits colon cancer invasion, migration and epithelial‐mesenchymal transition and tumour formation by upregulating miR‐185‐5p in vitro and in vivo

Cao, Chen; Zhang, Junhui; Yang, Chuanhua; Xiang, Lili; Liu, Wenneng

doi:10.1002/cbf.3454

Cited by 8 publications

(4 citation statements)

References 29 publications

(53 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To some extent, the contradictory results might be associated with differences in methodologies and analyzed material. For example, Cao et al [ 122 ] found that miR-185 was downregulated in CRC cell lines, SW480, SW620, and HT-29, compared to a non-cancerous colon cell line and miR-185 mimics inhibited cell proliferation and migration. Baldi et al [ 119 ] reported instead overexpression of miR-185 in CRC cell lines HCT116 and LoVo and thereby oncogenic activities.…”

Section: Discussionmentioning

confidence: 99%

“…As for other types of digestive tract cancers, lncRNAs have been identified to trigger CRC progression via miR-185 regulation ( Figure 3 ). High expression of lncRNA UCA1 in CRC cells led to a notable increase in the migration, invasion and EMT by binding to miR-185-5p, which directly activated the MAPK14/MAPKAPK2/Hsp27 axis [ 122 ] and repressed NOTCH3 [ 123 ]. In another study, overexpressed LINC00152 promoted CRC growth by sponging miR-185-3p and upregulating its direct target fascin actin-bundling protein 1 ( FSCN1 ).…”

Section: Colorectal Cancermentioning

confidence: 99%

See 1 more Smart Citation

The Roles of microRNA miR-185 in Digestive Tract Cancers

Babaeenezhad

Naghibalhossaini

Rajabibazl

et al. 2022

ncRNA

View full text Add to dashboard Cite

Digestive tract cancers represent a serious public health issue. In recent years, evidence has accumulated that microRNA miR-185 is implicated in the pathogenesis of this group of highly malignant tumors. Its expression variations correlate with clinical features, such as tumor size, lymph node metastasis, tumor node metastatic stage, survival, recurrence and response to adjuvant therapy, and have diagnostic and prognostic potential. In this review, we compile, evaluate and discuss the current knowledge about the roles of miR-185 in digestive tract cancers. Interestingly, miR-185 is apparently involved in regulating both tumor suppressive and oncogenic processes. We look at downstream effects as well as upstream regulation. In addition, we discuss the utility of miR-185 for diagnosis and its potential concerning novel therapeutic approaches.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Colorectal Cancermentioning

confidence: 99%

The Roles of microRNA miR-185 in Digestive Tract Cancers

Babaeenezhad

Naghibalhossaini

Rajabibazl

et al. 2022

ncRNA

View full text Add to dashboard Cite

show abstract

“…(Zhu et al, 2021) As an oncogenic gene, it regulates the proliferation, apoptosis, epithelial-mesenchymal transition , invasion, metastasis, and chemoresistance of gastric cancer cell lines, colon cancer cells,breast cancer cells, and other cancer cells. (Cao et al, 2020;Wo et al, 2022;Yang et al, 2021) The regulatory role of UCA1 in inflammation has been clarified in recent years, and its expression and inflammatory effects have ambivalent effects on different diseases. Yu vivo.…”

Section: Uca1mentioning

confidence: 99%

The Common LncRNAs of Neuroinflammation-Related Diseases

et al. 2022

View full text Add to dashboard Cite

Spatio-temporal specific lncRNAs play important regulatory roles not only in the growth and development of the brain but also in the occurrence and development of neurological diseases. Generally, the occurrence of neurological diseases is accompanied by neuroinflammation. Elucidation of the regulatory mechanisms of lncRNAs on neuroinflammation is helpful for the clinical treatment of neurological diseases. This paper focuses on recent findings on the regulatory effect of lncRNAs on neuroinflammatory diseases and selects ten lncRNAs that have been intensively studied to analyze their mechanism of action.The clinical treatment status of lncRNAs as drug targets is also reviewed. Significance StatementGene therapies such as CRISPR/Cas9 technology, antisense RNA technology and RNAi technology are gradually applied in clinical treatment, and the development of technology is based on a large number of basic research investigations. This paper focuses on the mechanisms of lncRNAs regulation of neuroinflammation, elucidates the beneficial or harmful effects of lncRNAs in neurosystemic diseases, and provides theoretical bases for lncRNAs as drug targets.

show abstract

“…For instance, it sponged miR-185-5p and led to overexpressed Wnt family member 1 (WNT1) and WNT1-inducible-signaling pathway protein 2 (WISP2); both activating WISP2/β-catenin signaling pathway to regulate autophagy and survival of CRC [71]. Apart from wnt1 and wisp2, mapk14 is also a target gene of miR-185-5p, where upregulation of mapk14 activated mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2)/ heat-shock protein 27 (HSP27) signaling pathway to promote invasion, migration, and EMT [72].…”

Section: Colorectal Cancermentioning

confidence: 99%

Long Noncoding RNA UCA1 in Gastrointestinal Cancers: Molecular Regulatory Roles and Patterns, Mechanisms, and Interactions

Ramli

Sim

Guad

et al. 2021

Journal of Oncology

View full text Add to dashboard Cite

The rising trend of gastrointestinal (GI) cancer has become a global burden due to its aggressive nature and poor prognosis. Long noncoding RNAs (lncRNAs) have recently been reported to be overexpressed in different GI cancers and may contribute to cancer progression and chemoresistance. They are featured with more than 200 nucleotides, commonly polyadenylated, and lacking an open reading frame. LncRNAs, particularly urothelial carcinoma-associated 1 (UCA1), are oncogenes involved in regulating cancer progression, such as cell proliferation, invasion, migration, and chemoresistance, particularly in GI cancer. This review was aimed to present an updated focus on the molecular regulatory roles and patterns of lncRNA UCA1 in progression and chemoresistance of different GI cancers, as well as deciphering the underlying mechanisms and its interactions with key molecules involved, together with a brief presentation on its diagnostic and prognostic values. The regulatory roles of lncRNA UCA1 are implicated in esophageal cancer, gastric cancer, pancreatic cancer, hepatobiliary cancer, and colorectal cancer, where they shared similar molecular mechanisms in regulating cancer phenotypes and chemoresistance. Comparatively, gastric cancer is the most intensively studied type in GI cancer. LncRNA UCA1 is implicated in biological roles of different GI cancers via interactions with various molecules, particularly microRNAs, and signaling pathways. In conclusion, lncRNA UCA1 is a potential molecular target for GI cancer, which may lead to the development of a novel chemotherapeutic agent. Hence, it also acts as a potential diagnostic and prognostic marker for GI cancer patients.

show abstract

Silencing of long noncoding RNA UCA1 inhibits colon cancer invasion, migration and epithelial‐mesenchymal transition and tumour formation by upregulating miR‐185‐5p in vitro and in vivo

Cited by 8 publications

References 29 publications

The Roles of microRNA miR-185 in Digestive Tract Cancers

The Roles of microRNA miR-185 in Digestive Tract Cancers

The Common LncRNAs of Neuroinflammation-Related Diseases

Long Noncoding RNA UCA1 in Gastrointestinal Cancers: Molecular Regulatory Roles and Patterns, Mechanisms, and Interactions

Contact Info

Product

Resources

About