Silencing of LINC00707 Alleviates Brain Injury by Targeting miR-30a-5p to Regulate Microglia Inflammation and Apoptosis

Hu, Wei; Zhou, Jiang; Jiang, Yiqing; Bao, Zeyu; Hu, Xiaoming

doi:10.1007/s11064-023-04029-0

Cited by 1 publication

(1 citation statement)

References 42 publications

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“…Most lncRNAs have been illustrated to regulate microglia polarization by modulating microRNA. Hu et al (97) demonstrated that the suppression of lncRNA LINC00707 mitigates brain injury by targeting miR-30a-5p, thereby regulating microglia inflammation. Meng et al (101) uncovered that lncRNA Meg3 intensifies microglial activation and the inflammatory response triggered by LPS and ATP stimulation.…”

Section: Ev-associated Ncrna-based Regulation Of Microglia Polarizati...mentioning

confidence: 99%

Extracellular vesicles as carriers for noncoding RNA-based regulation of macrophage/microglia polarization: an emerging candidate regulator for lung and traumatic brain injuries

Chen,

Zhang,

Pan

et al. 2024

Front. Immunol.

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Macrophage/microglia function as immune defense and homeostatic cells that originate from bone marrow progenitor cells. Macrophage/microglia activation is historically divided into proinflammatory M1 or anti-inflammatory M2 states based on intracellular dynamics and protein production. The polarization of macrophages/microglia involves a pivotal impact in modulating the development of inflammatory disorders, namely lung and traumatic brain injuries. Recent evidence indicates shared signaling pathways in lung and traumatic brain injuries, regulated through non-coding RNAs (ncRNAs) loaded into extracellular vesicles (EVs). This packaging protects ncRNAs from degradation. These vesicles are subcellular components released through a paracellular mechanism, constituting a group of nanoparticles that involve exosomes, microvesicles, and apoptotic bodies. EVs are characterized by a double-layered membrane and are abound with proteins, nucleic acids, and other bioactive compounds. ncRNAs are RNA molecules with functional roles, despite their absence of coding capacity. They actively participate in the regulation of mRNA expression and function through various mechanisms. Recent studies pointed out that selective packaging of ncRNAs into EVs plays a role in modulating distinct facets of macrophage/microglia polarization, under conditions of lung and traumatic brain injuries. This study will explore the latest findings regarding the role of EVs in the progression of lung and traumatic brain injuries, with a specific focus on the involvement of ncRNAs within these vesicles. The conclusion of this review will emphasize the clinical opportunities presented by EV-ncRNAs, underscoring their potential functions as both biomarkers and targets for therapeutic interventions.

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Section: Ev-associated Ncrna-based Regulation Of Microglia Polarizati...mentioning

confidence: 99%

Extracellular vesicles as carriers for noncoding RNA-based regulation of macrophage/microglia polarization: an emerging candidate regulator for lung and traumatic brain injuries

Chen,

Zhang,

Pan

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

show abstract

Silencing of LINC00707 Alleviates Brain Injury by Targeting miR-30a-5p to Regulate Microglia Inflammation and Apoptosis

Cited by 1 publication

References 42 publications

Extracellular vesicles as carriers for noncoding RNA-based regulation of macrophage/microglia polarization: an emerging candidate regulator for lung and traumatic brain injuries

Extracellular vesicles as carriers for noncoding RNA-based regulation of macrophage/microglia polarization: an emerging candidate regulator for lung and traumatic brain injuries

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