Silencing of H19 alleviates oxygen–glucose deprivation/reoxygenation-triggered injury through the regulation of the miR-1306-5p/BCL2L13 axis

Huang, Yuxing; Deng, Lisha; Zeng, Lin; Bao, Shanlin; Ye, Kun; Li, Chengxun; Hou, Xiaolin; Yuan, Yao; Li, Dingjun; Zhou, Xiong

doi:10.1007/s11011-021-00822-4

Cited by 5 publications

(2 citation statements)

References 45 publications

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“…In addition to in vivo I/R injury animal models, the oxygenglucose deprivation and reoxygenation (OGD/R) assay system has been used to examine the effects of miRNAs on BCL-RAMBO expression in in vitro cell cultures. The expression levels of miR-874-3p, miR-765, mi-526b-5p, miR-1306-5p, and miR-98-5p are reduced in OGD/R-induced neuroblastoma cells, which conversely up-regulates BCL-RAMBO expression, thereby promoting pathogenic changes, including apoptosis (Jiang et al, 2019;Lu et al, 2020;Guo et al, 2021;Huang et al, 2021;Zhang et al, 2022). The expression of miR-484 is down-regulated in mouse cortical neurons exposed to OGD/R, which promotes the expression of BCL-RAMBO (Liu et al, 2021).…”

Section: Regulation Of Bcl-rambo Expression By Micrornas (Mirnas)mentioning

confidence: 99%

“…SNHG15 promotes BCL-RAMBO expression by sponging miR-141-3p in osteoarthritis cartilage tissue (Zhang et al, 2020). In I/R injury and ODG/R, lncRNAs (i.e., FOXD3-AS1, H19, and SNHG14) are up-regulated and promote the expression of BCL-RAMBO by sponging their target miRNAs (Lu et al, 2020;Huang et al, 2021;Zhang et al, 2022). Circ_0062166, generated from exon 3 of BCL-RAMBO, is up-regulated following OGD/R and regulates BCL-RAMBO expression by sequestering miR-526b-5p (Guo et al, 2021).…”

Section: Regulation Of Bcl-rambo Expression By Micrornas (Mirnas)mentioning

confidence: 99%

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Biological properties of the BCL-2 family protein BCL-RAMBO, which regulates apoptosis, mitochondrial fragmentation, and mitophagy

Kataoka

2022

Front. Cell Dev. Biol.

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Mitochondria play an essential role in the regulation of cellular stress responses, including cell death. Damaged mitochondria are removed by fission and fusion cycles and mitophagy, which counteract cell death. BCL-2 family proteins possess one to four BCL-2 homology domains and regulate apoptosis signaling at mitochondria. BCL-RAMBO, also known as BCL2-like 13 (BCL2L13), was initially identified as one of the BCL-2 family proteins inducing apoptosis. Mitophagy receptors recruit the ATG8 family proteins MAP1LC3/GABARAP via the MAP1LC3-interacting region (LIR) motif to initiate mitophagy. In addition to apoptosis, BCL-RAMBO has recently been identified as a mitophagy receptor that possesses the LIR motif and regulates mitochondrial fragmentation and mitophagy. In the 20 years since its discovery, many important findings on BCL-RAMBO have been increasingly reported. The biological properties of BCL-RAMBO are reviewed herein.

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Section: Regulation Of Bcl-rambo Expression By Micrornas (Mirnas)mentioning

confidence: 99%

Section: Regulation Of Bcl-rambo Expression By Micrornas (Mirnas)mentioning

confidence: 99%

Biological properties of the BCL-2 family protein BCL-RAMBO, which regulates apoptosis, mitochondrial fragmentation, and mitophagy

Kataoka

2022

Front. Cell Dev. Biol.

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MiR-449b-5p Ameliorates Hypoxia-induced Cardiomyocyte Injury through Activating PI3K/AKT Pathway by Targeting BCL2L13

Jiang,

Liu,

et al. 2024

Appl Biochem Biotechnol

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Recent reports show miR-449b-5p reduces liver and renal ischemia/reperfusion (I/R) injury, but its effects on hypoxia-induced cardiomyocyte injury in ischemic heart disease are still unknown. In this study, AC16 human cardiomyocytes underwent hypoxic conditions for durations of 24, 48, and 72 h. We observed that miR-449b-5p expression was significantly downregulated in hypoxic AC16 cardiomyocytes. Elevating the levels of miR-449b-5p in these cells resulted in enhanced cell survival, diminished release of LDH, and a reduction in cell apoptosis and oxidative stress using CCK-8, LDH assays, flow cytometry, TUNEL staining, and various commercial kits. Conversely, reducing miR-449b-5p levels resulted in the opposite effects. Through bioinformatics analysis and luciferase reporter assays, BCL2-like 13 (BCL2L13) was determined to be a direct target of miR-449b-5p. Inhibiting BCL2L13 greatly inhibited hypoxia-induced cell viability loss, LDH release, cell apoptosis, and excessive production of oxidative stress, whereas increasing BCL2L13 negated miR-449b-5p’s protective impact in hypoxic AC16 cardiomyocytes. Additionally, miR-449b-5p elevated the levels of the proteins p-PI3K, p-AKT, and Bcl-2, while decreasing Bax expression in hypoxic AC16 cardiomyocytes by targeting BCL2L13. In summary, the research indicates that the protective effects of miR-449b-5p are facilitated through the activation of the PI3K/AKT pathway, which promotes cell survival, and by targeting BCL2L13, which inhibits apoptosis, offering a potential therapeutic strategy for ischemic heart disease by mitigating hypoxia-induced cardiomyocyte injury.

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Biliverdin modulates the long non-coding RNA H19/microRNA-181b-5p/endothelial cell specific molecule 1 axis to alleviate cerebral ischemia reperfusion injury

Jiang

Peng

et al. 2022

Biomedicine & Pharmacotherapy

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Silencing of H19 alleviates oxygen–glucose deprivation/reoxygenation-triggered injury through the regulation of the miR-1306-5p/BCL2L13 axis

Cited by 5 publications

References 45 publications

Biological properties of the BCL-2 family protein BCL-RAMBO, which regulates apoptosis, mitochondrial fragmentation, and mitophagy

Biological properties of the BCL-2 family protein BCL-RAMBO, which regulates apoptosis, mitochondrial fragmentation, and mitophagy

MiR-449b-5p Ameliorates Hypoxia-induced Cardiomyocyte Injury through Activating PI3K/AKT Pathway by Targeting BCL2L13

Biliverdin modulates the long non-coding RNA H19/microRNA-181b-5p/endothelial cell specific molecule 1 axis to alleviate cerebral ischemia reperfusion injury

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