Silencing and overexpression of human blood group antigens in transfusion: Paving the way for the next steps

Implementation of multiomic mass spectrometry approaches for the evaluation of human health following environmental exposure

“…Serum is a primary carrier of small molecules in the body and its chemical composition has been studied in the last 70 years. [169][170][171] The successful identification of biomarkers in blood, serum or plasma has a long history, which started with blood typing to guide blood transfusions, 172 followed by newborn metabolic screening for the early detection of metabolic diseases, 173 176 The potential of salivary inorganic constituents, antioxidants, hormones, antibodies and antigens as biomarkers in the diagnosis of several oral and systemic diseases is expanding and has been recently reviewed. 177 In oral diseases, saliva has been used to detect oral cavity cancer, dental caries, periodontal disease, and oral dryness.…”

“…Serum is a primary carrier of small molecules in the body and its chemical composition has been studied in the last 70 years. 169–171 The successful identification of biomarkers in blood, serum or plasma has a long history, which started with blood typing to guide blood transfusions, 172 followed by newborn metabolic screening for the early detection of metabolic diseases, 173 analysis of serum prostate-specific antigen for the early detection of prostate cancer 174 and dozens of other applications. Dozens of proteins have received FDA approval for clinical practice and most of them are for cancer diagnosis.…”