Sildenafil verändert nicht die koronare Flussreserve bei Diabetikern mit erektiler Dysfunktion

Abstract

Diabetics with erectile dysfunction often have a CFR in the lower range of normal. Sildenafil did not further reduce CFR. Asymptomatic, severe coronary artery disease often can be found in diabetics with erectile dysfunction. Cardiological screening for contraindications for sildenafil seems mandatory in diabetics with a high cardiovascular risk profile.

Acute effects of sildenafil on flow mediated dilatation and cardiovascular autonomic nerve function in type 2 diabetic patients

“…It is also conceivable that a single administration is not sufficient to improve vascular function and, hence, longer‐term treatment with PDE5 inhibitors is required as recently suggested 12, 13, 47, 53. Our data are in agreement with studies showing no effect of a single dose of sildenafil on endothelial function in smokers 16, healthy subjects 15, people with diabetes 54 and coronary heart disease (CHD) 17.…”