Sildenafil induced priapism

Adhikary, Samiran Das; Sinha, Mithilesh Kumar; Chacko, K.N.

doi:10.4103/0970-1591.26573

Cited by 3 publications

(5 citation statements)

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“…[ 2 ] However, priapism with isolated use of sildenafil in therapeutic dose has been documented rarely. [ 3 ] Medications containing nitrates, alpha blockers, HIV protease inhibitors, and St. John's wort has to taken very cautiously. Also, use of potent cytochrome P450 (CYP) 3A4 inhibitors namely macrolide and imidazole antimicrobials as well as non-specific CYP inhibitor cimetidine are associated with increased plasma levels of sildenafil and may aggravate the actions of sildenafil.…”

Section: Introductionmentioning

confidence: 99%

Priapism, pomegranate juice, and sildenafil: Is there a connection?

Balamurugan¹,

Suresh²,

Thirumalaikolundusubramanian³

2012

Urol Ann

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We report the development of low flow priapism in three patients related to simultaneous consumption of sildenafil with pomegranate (Punica granatum) (POM) juice. There were no other concurrent diseases, intake of drugs, and chemicals or other risk factors in these patients. We want to create awareness among patients and practitioners for recognition and timely intervention. Probable mechanisms are highlighted.

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Section: Introductionmentioning

confidence: 99%

Priapism, pomegranate juice, and sildenafil: Is there a connection?

Balamurugan¹,

Suresh²,

Thirumalaikolundusubramanian³

2012

Urol Ann

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“…More proximal shunts have been done for failed distal shunts. [3] The case reported here had priapism following a single dose of the usually prescribed dosage of 50 mg. An escalating dose starting at 12.5 mg and then increasing to 25 mg and followed by the usual prescribed dose of 50 mg may help to avoid the side effects of priapism. Unauthorized over-the-counter of the drug is to be condemned.…”

Section: Discussionmentioning

confidence: 95%

“…[2,3] The earlier reports of priapism following the use of sildenafil have been with self-administration of very large doses or in conditions predisposing to priapism. [4][5][6] Priapism may also follow simultaneous oral dose and intracavernous injection.…”

Section: Discussionmentioning

confidence: 99%

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Prolonged priapism following single dose administration of sildenafil: A rare case report

et al. 2009

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A case of priapism following the consumption of a single dose of sildenafil is reported. A 25-year-old unmarried healthy man consumed non-prescribed 50 mg sildenafil purchased over the counter. He developed painful priapism 30 min after the drug intake that had lasted for 4 days (96 h) when he sought medical advice as an emergency. The corpus spongiosum and glans was soft and the corpus cavernosa was rigid. Winter's shunt was done. Fifteen milliliters of dark blood was aspirated with 16 G needle. Detumescence was achieved within 30 min. He was discharged after 12 h. On one month follow-up, he had normal morning erections. A genetic basis with cross-reactivity of PDE-3 in addition to PDE-5 resulting in a cumulative erection effect may be possible elucidation for this unwanted side effect in rare cases. However, the number of cases reported with this side effect is still too less to draw further conclusions.

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“…Aphrodisiacs have side effects that cannot be ignored. A testament to this is the drug-induced priapism which has been reported by some researchers [18,19]. Although a sexual dysfunction results in serious psychological distress, priapism results in more significant pain because it is an emergent condition requiring urgent medical or surgical intervention and associated complications.…”

Section: Discussionmentioning

confidence: 99%

Penile fracture in a 32-year old man with sexual dysfunction: A case report of rare outcome of the use of aphrodisiacs

Dienye¹,

Nwapi²,

Dan-Jumbo³

2021

GSC Biol. and Pharm. Sci.

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Penile fracture is a very rare urological emergency resulting from the traumatic rupture of the tunica albuginea of one or both corpora cavernosa. Immediate surgical treatment is the current standard of care with lower risks of late complications, including erectile dysfunction, penile curvature, and tunical scar formation. We report a case of a patient with sexual dysfunction who took a combination of Anafranil and Sildenafil to enhance his sexual performance to satisfy his girlfriend, but ended with a penile fracture. Our case exposes the degree of frustration suffered by patients with sexual dysfunction and the extent to which they can go in the quest for a solution to their problem, the outcome may be unfavorable.Patients should be informed about the possible complications of Sildenafil either used singly or co-administered with Anafranil for improved sexual function, and recreational use of these drugs should be discouraged.

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Sildenafil induced priapism

Cited by 3 publications

References 0 publications

Priapism, pomegranate juice, and sildenafil: Is there a connection?

Priapism, pomegranate juice, and sildenafil: Is there a connection?

Prolonged priapism following single dose administration of sildenafil: A rare case report

Penile fracture in a 32-year old man with sexual dysfunction: A case report of rare outcome of the use of aphrodisiacs

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