Abstract:Background: Sildenafil (PDE5-inhibitor) and alprostadil (PGE 1 ) are used in combination clinically for the management of some cases of erectile dysfunction. Despite the roles of prostaglandins (PG) and NO pathways in contractility of bladder smooth muscle are frequently studied, the effect of sildenafil/alprostadil combination and the crosstalk between NO/cGMP and PG pathways on bladder activity is not documented.Methods: Organ-bath experiments were performed using isolated rat detrusor muscle. Direct and neu… Show more
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