Sildenafil as a Protecting Drug for Warm Ischemic Kidney Transplants: Experimental Results

Lledó-García, E.; Subirá-Ríos, D.; Rodríguez–Martínez, Daniel; Dulín, Elena; Álvarez-Fernández, Emilio; Hernández-Fernández, C.; Canizo-Lopez, J.F. Del

doi:10.1016/j.juro.2009.05.006

Cited by 23 publications

(19 citation statements)

References 13 publications

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“…Phosphodiesterase-5 (PDE-5) inhibitors such as sildenafil prevent the breakdown of nitric oxide (NO) driven cyclic guanosine monophosphate (cGMP) (5). The role of PDE-5 inhibitors in renal I/R injury is not well defined although there is some evidence to suggest a therapeutic effect against warm ischemic injury and a protective action against acute renal injury during cardiopulmonary bypass (12,13). Sildenafil is widely used in the treatment of pulmonary hypertension and erectile dysfunction (5,6).…”

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confidence: 99%

Sildenafil Citrate in a Donation After Circulatory Death Experimental Model of Renal Ischemia-Reperfusion Injury

Hosgood

Randle²,

Patel³

et al. 2014

Transplantation

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mentioning

confidence: 99%

Sildenafil Citrate in a Donation After Circulatory Death Experimental Model of Renal Ischemia-Reperfusion Injury

Hosgood

Randle²,

Patel³

et al. 2014

Transplantation

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“…The same is true for kidney transplants 13 14. In this case report, a subtotal severe occlusion of renal blood flow, leading to anuric acute renal failure for more than 8 weeks, was successfully treated with revascularisation surgery.…”

Section: Discussionmentioning

confidence: 73%

Renal artery stenosis: a classic presentation, a rare cause…

2012

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SummaryIn this case report, a patient is described with an unusual cause of renal artery stenosis (RAS). The patient presented with acute anuric renal failure and hypertensive urgency, following a nephrectomy, which was complicated by massive blood loss. Because the acute renal failure was first presumed to be due to acute tubular necrosis, the diagnosis of a nearly complete iatrogenic RAS was not made until 6 weeks after surgery. The stenosis was caused by five misplaced surgical clips on the artery of the remaining kidney. The hypertension was initially treated with ACE inhibitor. Eight weeks after the initial surgery, a successful revascularisation procedure was performed, leading to the recovery of kidney function. BACKGROUND

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“…Promising results have been shown for the use of SC in animal models of myocardial IRI, as well as inducing protective effects in the kidney 10,11 . However, the role of SC as a protective agent during IRI in skeletal muscles is still unknown.…”

Section: Ischemia-reperfusion Injury (Iri) In Skeletal Musclementioning

confidence: 99%

Sildenafil citrate protects skeletal muscle of ischemia-reperfusion injury: immunohistochemical study in rat model

Armstrong

Figueiredo³

et al. 2013

Acta Cir. Bras.

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PURPOSE:To investigate the effect of sildenafil citrate (SC) on skeletal muscle ischemia-reperfusion (IR) injury in rats. METHODS:Adult male Wistar rats were randomized into three groups: vehicle-treated control (CTG), sildenafil citrate-treated (SCG), and sham group (SG). CTG and SCG had femoral artery occluded for 6 hours. Saline or 1 mg/kg of SC was given 5.5 hours after occlusion. SG had a similar procedure without artery occlusion. Soleus muscle samples were acquired 4 or 24h after the reperfusion.Immunohistochemistry caspase-3 analysis was used to estimate apoptosis using the apoptotic ratio (computed as positive/negative cells). Wilcoxon rank-sum or Kruskal-Wallis tests were used to assess differences among groups. RESULTS:Eighteen animals were included in the 4h reperfusion groups and 21 animals in the 24h reperfusion groups. The mean apoptotic ratio was 0.18±0.1 for the total cohort; 0.14±0.06 for the 4h reperfusion groups and 0.19±0.08 for the 24h groups (p<0.05).The SCG had lower caspase-3 ratio compared to the control groups at the 24h reperfusion time point (p<0.05). CONCLUSION:Sildenafil citrate administration after the onset of the ischemic injury reduces IR-induced cellular damage in skeletal muscle in this rat hindlimb ischemia model. Sildenafil citrate protects skeletal muscle of ischemia-reperfusion injury.Immunohistochemical study in rat model

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Sildenafil as a Protecting Drug for Warm Ischemic Kidney Transplants: Experimental Results

Abstract: To our knowledge our study suggests for the first time in the literature a positive effect of sildenafil in the immediate posttransplantation outcome of warm ischemic kidneys without secondary systemic effects.

Cited by 23 publications

References 13 publications

Sildenafil Citrate in a Donation After Circulatory Death Experimental Model of Renal Ischemia-Reperfusion Injury

Sildenafil Citrate in a Donation After Circulatory Death Experimental Model of Renal Ischemia-Reperfusion Injury

Renal artery stenosis: a classic presentation, a rare cause…

Sildenafil citrate protects skeletal muscle of ischemia-reperfusion injury: immunohistochemical study in rat model

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