Sildenafil and tadalafil reduce the risk of contrast-induced nephropathy by modulating the oxidant/antioxidant balance in a murine model

Iordache, Andrei Mihai; Docea, Anca Oana; Buga, Ana-Maria; Zlatian, Ovidiu; Ciurea, Marius Eugen; Rogoveanu, Otilia Constantina; Burada, Florin; Sosoi, Simona; Mitruț, Radu; Mamoulakis, Charalampos; Albulescu, Dana Maria; Vasile, Ramona Constantina; Tsatsakis, Aristidis; Calina, Daniela

doi:10.1016/j.fct.2019.111038

Cited by 33 publications

(31 citation statements)

References 57 publications

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“…Other agents such as cardiotrophin-1 and antithrombin III, [53,54] exendin-4, [55] β-receptor antagonist, [56,57] phosphodiesterase-5 inhibitor, [58][59][60][61] an mTOR inhibitor, [62] exogenous sphingosylphosphorylcholine, [63] and sodium bicarbonate; [64] have been investigated in CIN models (Table 4 and Fig. 3).…”

Section: Antioxidants As Interventions To Reduce Cinmentioning

confidence: 99%

Contrast-induced nephropathy and oxidative stress: mechanistic insights for better interventional approaches

Kusirisin

Chattipakorn

2020

J Transl Med

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Contrast-induced nephropathy (CIN) or contrast-induced acute kidney injury (CI-AKI) is an iatrogenic acute kidney injury observed after intravascular administration of contrast media for intravascular diagnostic procedures or therapeutic angiographic intervention. High risk patients including those with chronic kidney disease (CKD), diabetes mellitus with impaired renal function, congestive heart failure, intraarterial intervention, higher volume of contrast, volume depletion, old age, multiple myeloma, hypertension, and hyperuricemia had increased prevalence of CIN. Although CIN is reversible by itself, some patients suffer this condition without renal recovery leading to CKD or even end-stage renal disease which required long term renal replacement therapy. In addition, both CIN and CKD have been associated with increasing of mortality. Three pathophysiological mechanisms have been proposed including direct tubular toxicity, intrarenal vasoconstriction, and excessive production of reactive oxygen species (ROS), all of which lead to impaired renal function. Reports from basic and clinical studies showing potential preventive strategies for CIN pathophysiology including low- or iso-osmolar contrast media are summarized and discussed. In addition, reports on pharmacological interventions to reduce ROS and attenuate CIN are summarized, highlighting potential for use in clinical practice. Understanding this contributory mechanism could pave ways to improve therapeutic strategies in combating CIN.

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Section: Antioxidants As Interventions To Reduce Cinmentioning

confidence: 99%

Contrast-induced nephropathy and oxidative stress: mechanistic insights for better interventional approaches

Kusirisin

Chattipakorn

2020

J Transl Med

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“…In a recent study, it was shown that in rat nephropathy, Tadalafil acts by increasing the enzymatic and non-enzymatic antioxidant system capacity level of total GSH, GPx, CAT and SOD. This adaptive response could potentially control the production of ROS by modifying the oxidant/ antioxidant constancy induced by Tadalafil administration (Iordache et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Tadalafil Attenuates γ-Rays-Induced Hepatic Injury in Rats

Khouly

Ebrahim

2020

Egypt. J. Rad.Sci.

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T ADALAFIL is widely used in the treatment of many disease disorders. Tadalafil is studied for its protective effect against γ-rays-induced hepatic injury in rats. Rats were exposed to 6 Gy-γ-rays then, treated with Tadalafil for 7-days and compared to the control, Tadalafil alone and irradiated groups. Oxidative-stress markers; malondialdehyde (MAD) and myeloperoxidase (MPO) and the antioxidant markers; reduced glutathione (GSH) content, and the relative enzyme activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were evaluated in liver tissues. The anti-inflammatory markers; tumour necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were evaluated in the blood serum. Data revealed a significant reduction in the γ-rays-induced lipid-peroxidation; MDA content, MPO activity, the inflammatory markers levels of TNF-α and IL-6, and an augmentation in the antioxidant marker levels of GSH, GPx, CAT and SOD. It could be concluded that Tadalafil could alleviate the toxic effects of ionizing radiation in liver via the strong anti-oxidant and anti-inflammatory impact, thus could be useful as a radio protective agent in the radiotherapy schedule. The radio protective influence of Tadalafil could need to be explored for further organs in imminent works.

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“…Sildenafil is an orally administered phosphodiesterase type 5 (PDE5) inhibitor that permits corpus cavernosum smooth muscle to relax and potentiating erections during sexual stimulation (Langtry and Markham, 1999;Georgiadis et al, 2020;Iordache et al, 2020a). It is also reported that the sildenafil can inhibit the breakdown of cyclic guanosine monophosphate (cGMP) through binding at the phosphodiesterase binding site (Iordache et al, 2020b;Rogosnitzky et al, 2020). A pilot study of sildenafil is designed in phase 3 clinical trial (NCT04304313) to check its citrate form tablet's safety, efficacy, and tolerability at a dose of 0.1g/day for 14 days in 10 COVID-19 patients (Clinicaltrials.Gov, 2020ba).…”

Section: Sildenafilmentioning

confidence: 99%

Potential Therapeutic Options for COVID-19: Current Status, Challenges, and Future Perspectives

et al. 2020

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The COVID-19 pandemic represents an unprecedented challenge for the researchers to offer safe, tolerable, and effective treatment strategies for its causative agent known as SARS-CoV-2. With the rapid evolution of the pandemic, even the off-label use of existing drugs has been restricted by limited availability. Several old antivirals, antimalarial, and biological drugs are being reconsidered as possible therapies. The effectiveness of the controversial treatment options for COVID-19 such as nonsteroidal antiinflammatory drugs, angiotensin 2 conversion enzyme inhibitors and selective angiotensin receptor blockers was also discussed. A systemic search in the PubMed, Science Direct, LitCovid, Chinese Clinical Trial Registry, and ClinicalTrials.gov data bases was conducted using the keywords "coronavirus drug therapy," passive immunotherapy for COVID-19', "convalescent plasma therapy," (CPT) "drugs for COVID-19 treatment," "SARS-CoV-2," "COVID-19," "2019-nCoV," "coronavirus immunology," "microbiology," "virology," and individual drug names. Systematic reviews, case presentations and very recent clinical guidelines were included. This narrative review summarizes the available information on possible therapies for COVID-19, providing recent data to health professionals.

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Sildenafil and tadalafil reduce the risk of contrast-induced nephropathy by modulating the oxidant/antioxidant balance in a murine model

Cited by 33 publications

References 57 publications

Contrast-induced nephropathy and oxidative stress: mechanistic insights for better interventional approaches

Contrast-induced nephropathy and oxidative stress: mechanistic insights for better interventional approaches

Tadalafil Attenuates γ-Rays-Induced Hepatic Injury in Rats

Potential Therapeutic Options for COVID-19: Current Status, Challenges, and Future Perspectives

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