Signs of a “Broken Heart”: Suspected Muehrcke Lines After Cardiac Surgery

Weiser, Jessica A.

doi:10.1001/archderm.143.6.815-b

Cited by 8 publications

(2 citation statements)

References 3 publications

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“…[ 1 ] Muehrcke’s lines accompany severely low serum albumin,[ 23 ] probably resulting from vascular compression within the nail bed because of local edema. They have also been associated with multiple etiologies including nephrotic syndrome, liver cirrhosis, severe malnutrition, anticancer therapy,[ 24 ] severe cachexia in AIDS,[ 25 ] Cushing’s syndrome,[ 26 ] and even in patients with transient hypoalbuminemia,[ 27 ] or normoalbuminemia. [ 28 ] They were seen in many of our patients, both with normal and reduced serum proteins.…”

Section: Discussionmentioning

confidence: 99%

Nail Changes in COVID-19

Grover

Saha

Pandhi

2022

Indian Dermatology Online Journal

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Background: Various nail manifestations have been reported with COVID-19; mostly in the form of isolated reports. Objective: This cross-sectional study was carried out to assess nail changes in hospitalized patients with moderate to severe COVID-19. Methods: Nail findings in 43 adults being treated for COVID-19, were evaluated after obtaining informed written consent. Nail changes involving fingernails and toenails were documented as new-onset or pre-existing changes. Disease status, hematological and biochemical tests, inflammatory markers, treatment administered and outcomes were also recorded. The frequency of changes in fingernails and toenails were statistically compared. Results: The red half-moon sign (32.5%) and nail bed erythema (34.8%) were the commonest changes seen in fingernails; while apparent leukonychia (46.5%) and distal brown discoloration (51.1%) were commonest changes in toenails. The difference in frequency of changes seen between fingernails and toenails was statistically significant (p < 0.05). Nail changes correlated with systemic involvement in these patients. Limitations: Single-center evaluation in a limited number of patients, without using augmented examination techniques like onychoscopy, nail fold capillaroscopy, or fluoroscence. Those with less severe disease or with rapid fatality could not be studied. Conclusion: Nail changes in COVID-19 are common and reflect the systemic nature of illness, being a harbinger of underlying complications.

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Section: Discussionmentioning

confidence: 99%

Nail Changes in COVID-19

Grover

Saha

Pandhi

2022

Indian Dermatology Online Journal

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“…8 ). Initially described in 1956 by their namesake Dr. Robert Muehrcke in patients with severe and long-standing hypoalbuminemia (< 2.2 g/100 mL) [ 82 ], currently they are considered indicative of a range of systemic pathologies without hypoalbuminemia, including kidney disease, rheumatoid arthritis, heart transplant [ 86 , 87 ], and after placement of a left ventricular assist device [ 88 ]. Systemic retinoids and various cytostatic regimens have also been observed to cause them.…”

Section: Clinical Presentationsmentioning

confidence: 99%