Signs in Disorders of Lipid Metabolism and Obesity

Manni, Andrea; Quarde, Akuffo

doi:10.1007/978-3-030-49872-6_7

Cited by 1 publication

(1 citation statement)

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“…HDL is an important lipoprotein which is involved in reverse cholesterol transport, draws the excess cholesterol from cell membranes, and also inhibits the oxidation of LDL-C in the blood [17]. Clinical expressions of hyperlipoproteinaemia comprise a larger incidence of ischemic cardiovascular disease, acute pancreatitis, and yellowish deposits of lipid underneath the skin, called xanthelasmas, which usually occurs around the eyelids [18].…”

Section: Discussionmentioning

confidence: 99%

Hypolipidemic action of Rutin on Triton WR-1339 induced hyperlipidemia in rats

Nr¹,

Nair²,

Senthilpandian³

et al. 2021

J Pre Clin Clin Res.

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Introduction and objective. Hyperlipidemia is considered as a serious communal problem in developed countries, caused by an excess level of cholesterol in blood circulation. It leads to chronic illness and even death in human beings. As the currently available drugs cause unexpected side-effect, the aim of this study is to concentrate on naturally occurring flavonoids which can potentially provide defensive and therapeutic effects in atherosclerosis diseases, and investigate the hypolipidemic effect of rutin on Triton WR-1339 triggered hyperlipidemia in a rat blood sample. Materials and method. Rats were randomly prearranged into five different groups of five rats each. Group-I was the non-disease control and administered normal saline. Group-II was the atherogenic control, administered Triton WR 1339 (200 mg/kg BW). Group-III was standard and received Atorvastatin. The last two groups (IV, V) were tested (I&II) by administering administered Rutin (40 mg/kg, 80 mg/kg) orally. The test material (I&II) and the standard drug were administered for seven days. After the last dose, blood samples were collected and the lipid levels estimated in the blood samples. Results. Rats treated with rutin flavonoid at a dose of 40 mg/kg & 80mg/kg exhibited a reduction in Total Cholesterol, Triglycerides, Low Density Lipoprotein (LDL) and Very Low Density Lipoprotein (VLDL). Rutin also increases the High Density Lipoprotein (HDL), compared with control rats. Rutin treated rats exhibited dose-dependent hypolipidemic activity. The protection percentage of rutin against hyperlipidemia was observed as 41.89%, 55.57% whereas the atorvastatin treated group protection was observed at 60.63%. Conclusions. The results of the study revealed that rutin showed a significant hypolipidemic effectiveness on Triton WR-1339 induced hyperlipidemia in rats.

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Section: Discussionmentioning

confidence: 99%