Signs and Symptoms of Uveitis*

Hogan, Michael J.; Kimura, Samuel J.; Thygeson, Phillips

doi:10.1016/s0002-9394(14)78239-x

Cited by 447 publications

(186 citation statements)

References 2 publications

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“…The following scale modified from Hogan et al was used to reconcile different ophthalmologists' methods of grading anterior chamber inflammation: trace = <5 cells/HPF, 1+ = 5-9 cells/HPF, 2+ = 10-19 cells/HPF, 3+ = 20-50 cells/HPF, 4+ >50 cells/HPF. 17 A uveitis recurrence during the study period was defined as at least two grade change in ocular inflammation leading to a change in local or systemic therapy.…”

Section: Methodsmentioning

confidence: 99%

Infliximab to Treat Chronic Noninfectious Uveitis in Children: Retrospective Case Series with Long-term Follow-up

Ardoin

Kredich

Rabinovich

et al. 2007

American Journal of Ophthalmology

104

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Section: Methodsmentioning

confidence: 99%

Infliximab to Treat Chronic Noninfectious Uveitis in Children: Retrospective Case Series with Long-term Follow-up

Ardoin

Kredich

Rabinovich

et al. 2007

American Journal of Ophthalmology

104

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“…All patients received a standard ocular evaluation, which included a slit lamp examination, and an examination while the pupils were dilated, which included evaluation of the posterior pole with either a Hruby lens, contact lens, or indirect ophthalmoscopy. Ocular inflammatory activity for the anterior and posterior segment was judged on the basis of previously reported criteria (13,14). Patients entering the study received 10 mgkg/day of cyclosporin, orally.…”

Section: Methodsmentioning

confidence: 99%

Effectiveness of cyclosporin therapy for Beh¸let's disease

Nussenblatt

Palestine

Chan

et al. 1985

Arthritis & Rheumatism

192

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Behçet's disease is a clinical entity with mouth and genital ulcers, skin lesions, and both anterior and posterior uveitis as its major criteria. It has been theorized that Behçet's disease is immune complex mediated, and is characterized by multiple attacks which often lead to severe visual handicap. Behçet's disease patients with severe ocular involvement and cytotoxic and/or systemic corticosteroid agent failures were treated with cyclosporin (CsA). CsA therapy effectively abrogated the acute phase of the ocular attack and either totally prevented, or markedly reduced, the recurrences of these attacks. Generally, patients tolerated the medication well; occasionally however, renal toxicity secondary to cyclosporin therapy prevented prescription of a maximally effective therapeutic dose of the drug. CsA levels in plasma were dose‐dependent for each patient, but the dosage per kg of CsA needed to obtain a specific plasma level varied greatly from patient to patient. Circulating immune complex levels were not universally elevated during the acute ocular attack. However, increases in circulating immune complex concentrations were noted after treatment with CsA was begun and the disease became clinically inactive. These data, as well as the effectiveness of CsA, an agent with predominantly anti–T cell effects, raise a question as to whether circulating immune complexes are centrally relevant to the pathogenesis of this disorder, and if T cell mediation of this disease must be contemplated.

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“…The intraocular pressure was measured 5 times a day, basically at 8, 12, 15, 18, and 21 o'clock for two days. Aqueous cells and flare were graded into 4 levels from π1 to π4 according to Hogan's grading system (Hogan et al 1959).…”

Section: Methodsmentioning

confidence: 99%