Significantly Increased IgG2 Subclass Antibody Levels to Blastocystis hominis in Patients with Irritable Bowel Syndrome

Hussain, Rabia; Jaferi, Wasim; Zuberi, Sarwar J.; Baqai, R; Abrar, Nabila; Ahmed, Ashfaq; Zaman, V.

doi:10.4269/ajtmh.1997.56.301

Cited by 84 publications

(63 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In a study in Pakistan, Hussain et al (1997) found that levels of antibody against Blastocystis were higher in patients with IBS than in controls but, surprisingly, levels in IBS patients were the same whether the parasite was detected concurrently or not. In Mexico and Thailand, three studies failed to show a higher prevalence of Blastocystis in IBS patients (Ramirez-Miranda et al, 2010;Surangsrirat et al, 2010;Tungtrongchitr et al, 2004).…”

Section: Links To Irritable Bowel Syndromementioning

confidence: 93%

Recent Developments in Blastocystis Research

Clark

Giezen

Alfellani

et al. 2013

Advances in Parasitology

251

216

View full text Add to dashboard Cite

Abstract:Blastocystis is a common parasite of the human large intestine but has an uncertain role in disease. In this review, we appraise the published evidence addressing this and its weaknesses. Genetic diversity studies have led to the identification of numerous subtypes within the genus Blastocystis and, recently, methods for studying variation within subtypes have been developed, with implications for our understanding of host specificity. The geographic distribution of subtypes is summarised and the impact this may have on investigations into the role of the organism in disease is discussed. Finally, we describe the organelle and nuclear genome characteristics and look to future developments in the field.

show abstract

Section: Links To Irritable Bowel Syndromementioning

confidence: 93%

Recent Developments in Blastocystis Research

Clark

Giezen

Alfellani

et al. 2013

Advances in Parasitology

251

216

View full text Add to dashboard Cite

show abstract

“…Blastocystis infections lead to immunoglobulin G (IgG) and IgA responses, as detected by indirect fluorescent antibody (IFA) testing and enzyme-linked immunosorbent assay (ELISA) (104,112,143,323,328). ELISA titers ranged from 1:50 to 1:1,600 (328), and previously reported studies revealed that high titers are associated with symptomatic infections (104,143,323,328).…”

Section: Serologymentioning

confidence: 99%

“…Accumulating reports also suggest an association between Blastocystis and irritable bowel syndrome (IBS), a functional bowel disorder in which abdominal pain is associated with a defect or a change in bowel habits (82,104,144,293). In two studies (82,293), Blastocystis was detected more frequently in IBS patients than in a control group consisting of IBS-negative patients with gastrointestinal symptoms.…”

Section: Infection and Diseasementioning

confidence: 99%

Extreme anoxia tolerance in embryos of the annual killifishAustrofundulus limnaeus: insights from a metabolomics analysis

Podrabsky

Lopez

Fan

et al. 2007

Journal of Experimental Biology

128

154

View full text Add to dashboard Cite

SUMMARY The annual killifish Austrofundulus limnaeus survives in ephemeral pond habitats by producing drought-tolerant diapausing embryos. These embryos probably experience oxygen deprivation as part of their normal developmental environment. We assessed the anoxia tolerance of A. limnaeus embryos across the duration of embryonic development. Embryos develop a substantial tolerance to anoxia during early development, which peaks during diapause II. This extreme tolerance of anoxia is retained during the first 4 days of post-diapause II development and is then lost. Metabolism during anoxia appears to be supported mainly by production of lactate, with alanine and succinate production contributing to a lesser degree. Anoxic embryos also accumulate large quantities of γ-aminobutyrate (GABA), a potential protector of neural function. It appears that the suite of characters associated with normal development and entry into diapause II in this species prepares the embryos for long-term survival in anoxia even while the embryos are exposed to aerobic conditions. This is the first report of such extreme anoxia tolerance in a vertebrate embryo, and introduces a new model for the study of anoxia tolerance in vertebrates.

show abstract

“…Serolojik bir çalışmada ise İBS hastaların-da Blastocystis'e karşı IgG2 değerlerinin yüksek olduğu bulunmuştur (14). Bazı araştırıcılar ise kontrol grubu ile karşılaştırıldığın-da İBS ile Blastocystis spp.…”

Section: Introductionunclassified

İrrite Bağırsak Sendromunda Dientamoeba fragilis ve Blastocystis spp.'nin Rolü

Mumcuoğlu¹,

Coşkun²,

Aksu³

et al. 2013

TurkiyeParazitolDerg

View full text Add to dashboard Cite

ÖZET Amaç: Bu çalışmada, irrite bağırsak sendromu (İBS) tanısı konulmuş hastalarda Dientamoeba fragilis ve Blastocystis spp. parazitlerinin sıklığı ve İBS oluşumuyla ilişkilerinin araştırılması amaçlanmıştır. Yöntemler: İBS tanısı almış 55 hastadan, akut gastroenterit şikayetleri olan 80 hastadan oluşan grubu 1'den (KG-1) ve sağlıklı 50 gönüllüden oluşan Kontrol Grubu 2'den (KG-2) toplanan dışkı örnekleri çalışmaya alınmıştır. Örnekler direkt mikroskobi, trikrom boyama ve spesifik kültür yapılarak incelenmiştir. Bulgular: Blastocystis spp. görülme sıklığı açısından İBS hasta grubu ile KG-1 arasında anlamlı fark görülmezken (p>0,05), KG-2 arasında anlamlı fark bulunmuştur (p<0,05). İBS hasta grubunda, direkt mikroskobide (X40) her sahada 5 ve üzeri Blastocystis spp. görülmesi kontrol gruplarından daha sıktır. Tedavi sonrası takiplerde 4 (%22,2) hasta şikayetlerinin tamamen geçtiğini bildirirken, 11 (%61,1) hasta diğer bulgularda hafifleme olmakla birlikte kabızlığın devam ettiğini, 3 (%16,7) hasta ise şikayetlerinde hiçbir değişiklik olmadığını bildirmiştir. Hiçbir örnekte D. fragilis tespit edilmemiştir. Sonuç: Hiçbir hastada D. fragilis tespit edilememiş olmasının nedeni bölgemizde bu parazitin infeksiyon oranının düşük olmasına bağlı olabilir. İBS hastalarında her mikroskobi sahasında (X40) 5 ve üzeri Blastocystis spp.'nin sık görülmesi ve bu hastaların önemli bir kısmında tedavi ile şikayetlerin gerilemesi, İBS ile Blastocystis spp. enfeksiyonları arasında bir bağlantı olabileceğini düşündürmüştür. (Turkiye Parazitol Derg 2013; 37: 73- Methods: Stool specimens collected from 55 IBS patients, 80 patients with gastroenteritis as control group 1 (CG-1) and 50 healthy volunteers as control group 2 (CG-2) were included the study. Samples were examined by direct microscopy, trichrome staining and culture methods. Results: While there was no significant difference in the prevalence of Blastocystis spp. between IBS patients and CG-1 (p>0.05), a significant difference was found between IBS and CG-2 (p<0.05). Patients with IBS were found to have five or more Blastocystis spp. per field than control groups. After eradication, all symptoms were cured in four patients, there were only constipation problems left in eleven patients and there were no changes in clinical findings in three patients. D. fragilis was not found in any of the samples. Conclusion:The reason we did not find any D. fragilis may be due to the low infection rate in the region. However, significantly having five or more Blastocystis spp. per field (X40) in IBS patients and regression of IBS symptoms after treatment in most of the patients suggested a possible link between IBS and Blastocystis spp. (Turkiye Parazitol Derg 2013; 37: 73-7)

show abstract

Significantly Increased IgG2 Subclass Antibody Levels to Blastocystis hominis in Patients with Irritable Bowel Syndrome

Cited by 84 publications

References 0 publications

Recent Developments in Blastocystis Research

Recent Developments in Blastocystis Research

Extreme anoxia tolerance in embryos of the annual killifishAustrofundulus limnaeus: insights from a metabolomics analysis

İrrite Bağırsak Sendromunda Dientamoeba fragilis ve Blastocystis spp.'nin Rolü

Contact Info

Product

Resources

About