Significant Variations in Double-Stranded RNA Levels in Cultured Skin Cells
Shaymaa Sadeq,
Suwalak Chitcharoen,
Surar Al-Hashimi
et al.
Abstract:Endogenous double-stranded RNA has emerged as a potent stimulator of innate immunity. Under physiological conditions, endogenous dsRNA is maintained in the cell nucleus or the mitochondria; however, if protective mechanisms are breached, it leaches into the cytoplasm and triggers immune signaling pathways. Ectopic activation of innate immune pathways is associated with various diseases and senescence and can trigger apoptosis. Hereby, the level of cytoplasmic dsRNA is crucial. We have enriched dsRNA from two m… Show more
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