Significant Role of Interleukin-8 in Pathogenesis of Pulmonary Disease Due to
            <i>Mycoplasma pneumoniae</i>
            Infection

Narita, Mitsuo; Tanaka, Hiroshi; Yamada, Satoshi; Abe, Shosaku; Ariga, Tadashi; Sakiyama, Yukio

doi:10.1128/cdli.8.5.1028-1030.2001

Cited by 41 publications

(30 citation statements)

References 11 publications

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“…In many of these conditions, neutrophils are the predominant inflammatory cell type and are considered to be an important contributor to the pathogenesis. Through its ability to attract and activate neutrophils from the bloodstream, IL-8 likely contributes to the pathogenesis of various lung diseases caused by M. pneumoniae (45). Neutrophils amplify the inflammation and injure the airways through the release of inflammatory cytokines, proteases, and reactive oxygen and nitrogen intermediates (54,72).…”

Section: Discussionmentioning

confidence: 99%

“…IL-8 is produced by a wide array of cell types, including epithelial cells, neutrophils, and macrophages in response to microbial infections (42). IL-8 and its murine equivalent KC have been shown to contribute to the pulmonary and extrapulmonary inflammation following M. pneumoniae infection (14,18,44,45). Patients with M. pneumoniae lung infections have increased IL-8 in their bronchoalveolar lavages, and the levels of IL-8 correlate with higher bacterial loads and impairment of gas exchange (6).…”

mentioning

confidence: 99%

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Induction of IL-8 byMycoplasma pneumoniaemembrane in BEAS-2B cells

Chmura

Bai²,

Nakamura³

et al. 2008

American Journal of Physiology-Lung Cellular and Molecular Phys

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Mycoplasma pne umoniae is an extracellular pathogen, residing on mucosal surfaces of the respiratory and genital tracts. The lack of cell walls in mycoplasmas facilitates the direct contact of the bacterial membrane with the host cell. The cell membrane of mycoplasma is the major inducer of the host pathogenic response. Airway diseases caused by M. pneumoniae include bronchiolitis, bronchitis, and rarely bronchiectasis. In such disorders, neutrophil infiltration of the airways predominates. More recently, M. pneumoniae has been implicated in the pathogenesis of asthma. Epithelial cells play an important role in recruiting inflammatory cells into the airways. Since M. pneumoniae infection of human epithelial cells induces expression of IL-8—a potent activator of neutrophils—we investigated the signaling and transcriptional mechanisms by which mycoplasma membrane induces expression of this chemokine. In BEAS-2B human bronchial epithelial cells, mycoplasma membrane fraction (MMF) increased IL-8 mRNA and protein production. Activation of the transcriptional elements activating protein-1, nuclear factor-interleukin-6, and particularly NF-κB are essential for optimal IL-8 production by MMF. The mitogen-activated protein kinases individually played a modest role in MMF-induced IL-8 production. Toll-like receptor-2 did not play a significant role in MMF-induction of IL-8. Antibiotics with microbicidal activity against M. pneumoniae are also known to have anti-inflammatory effects. Whereas clarithromycin, azithromycin, and moxifloxacin individually were able to inhibit TNF-α-induction of IL-8, each failed to inhibit MMF-induction of IL-8.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Induction of IL-8 byMycoplasma pneumoniaemembrane in BEAS-2B cells

Chmura

Bai²,

Nakamura³

et al. 2008

American Journal of Physiology-Lung Cellular and Molecular Phys

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“…In addition, no apparent treatment failure or serious illness was reported for patients with MR M. pneumoniae infection. Experimental and clinical evidence supports the idea that the pathogenesis of lung injuries caused by M. pneumoniae infection is associated with cellmediated immunity rather than with direct cell damage caused by the pathogen itself (20)(21)(22)(23). Numerous studies have documented that certain macrolides have a wide spectrum of immunomodulatory effects on mammalian cells both in vivo and in vitro (24).…”

mentioning

confidence: 87%

Nationwide Surveillance of Macrolide-Resistant Mycoplasma pneumoniae Infection in Pediatric Patients

Kawai

Miyashita

Kubo

et al. 2013

Antimicrob Agents Chemother

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We conducted nationwide surveillance to investigate regional differences in macrolide-resistant (MR) Mycoplasma pneumoniae strains in Japan. The prevalence of MR M. pneumoniae in pediatric patients gradually increased between 2008 and 2012. Although regional differences were observed, high levels of MR genes were detected in all seven surveillance areas throughout Japan and ranged in prevalence from 50% to 93%. These regional differences were closely related to the previous administration of macrolides.

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“…CD4 ϩ T lymphocytes, B lymphocytes, and plasma cells infiltrate the lung (65,318), manifested radiologically as pulmonary infiltrates. Further amplification of the immune response in association with lymphocyte proliferation, production of immunoglobulins, and release of tumor necrosis factor alpha (TNF-␣), gamma interferon (IFN-␥), and various interleukins (including interleukin-1␤ [IL-1␤], IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, and IL-18) occurs, based on evidence from clinical and in vitro studies and from animal models (193,195,263,308,309,406,420,447,448). Many of these reactive substances will have elevated levels in both alveolar fluid and serum (233,263,406,448).…”

Section: Cytotoxicity and Inflammationmentioning

confidence: 99%

Mycoplasma pneumoniaeand Its Role as a Human Pathogen

2004

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Mycoplasma pneumoniae is a unique bacterium that does not always receive the attention it merits considering the number of illnesses it causes and the degree of morbidity associated with it in both children and adults. Serious infections requiring hospitalization, while rare, occur in both adults and children and may involve multiple organ systems. The severity of disease appears to be related to the degree to which the host immune response reacts to the infection. Extrapulmonary complications involving all of the major organ systems can occur in association with M. pneumoniae infection as a result of direct invasion and/or autoimmune response. The extrapulmonary manifestations are sometimes of greater severity and clinical importance than the primary respiratory infection. Evidence for this organism's contributory role in chronic lung conditions such as asthma is accumulating. Effective management of M. pneumoniae infections can usually be achieved with macrolides, tetracyclines, or fluoroquinolones. As more is learned about the pathogenesis and immune response elicited by M. pneumoniae, improvement in methods for diagnosis and prevention of disease due to this organism may occur

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Significant Role of Interleukin-8 in Pathogenesis of Pulmonary Disease Due to Mycoplasma pneumoniae Infection

Cited by 41 publications

References 11 publications

Induction of IL-8 byMycoplasma pneumoniaemembrane in BEAS-2B cells

Induction of IL-8 byMycoplasma pneumoniaemembrane in BEAS-2B cells

Nationwide Surveillance of Macrolide-Resistant Mycoplasma pneumoniae Infection in Pediatric Patients

Mycoplasma pneumoniaeand Its Role as a Human Pathogen

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