Significant Reduction in Aortic Strain after Endovascular Aneurysm Repair Using Novel Ultrasound Elastography Technique

Abstract

INTRODUCTION:The clinical outcomes after revascularization for arterial occlusive disease are associated with sex differences. Although these sex differences are associated with neointimal hyperplasia, sex differences in arterial identity during remodeling are not known. We characterized sex differences in vessel identity, including the arterial determinant Ephrin-B2, that occur during arterial remodeling after injury. METHODS: Carotid balloon injury was performed in male and female Sprague-Dawley rats, with or without preceding gonadectomy. Balloon injury was performed on the left common carotid artery, and the contralateral artery was used for control. Ultrasonography was used to assess hemodynamics, and wall composition was assessed using histology, immunofluorescence, and Western blot (day 14).