Significant of Big Data in various fields

Nitric oxide- and cisplatin-releasing silica nanoparticles for use against non-small cell lung cancer

“…The small difference in the rate of release may affect the sterics of the NONOate in the Si-DETA-cisplatin-AMS1 sample. A similar phenomenon has been reported for the solubility of cisplatin from cisplatin/ hydroxypropyl-β-cyclodextrin complex at different pH values [72]. This study was conducted until all cisplatin had released in order to obtain the total dissolved cisplatin in SBF medium at 37°C.…”

Host–guest inclusion systems of Pt(IV)-bis(benzoato) anticancer drug candidates and cyclodextrins

“…In the literature, only a limited number of papers deal with the use of CDs as encapsulatory vehicles for Pt complexes. The efficacy of CDs in enhancing the solubility of cisplatin [10], carboplatin, oxaliplatin and nedaplatin has been demonstrated [11,12,13] and patented [14,15,16].…”