Significant Infections After Hand Transplantation in a Polish Population

Kamińska, Dorota; Kościelska‐Kasprzak, Katarzyna; Márta, Mészáros; Banasik, Mirosław; Chełmoński, Adam; Boratyńska, Maria; Jabłecki, Jerzy; Klinger, Milton E.

doi:10.1016/j.transproceed.2014.08.028

Cited by 10 publications

(6 citation statements)

References 20 publications

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“…More than 200 cases of vascularized composite allografts (VCA) have been performed worldwide confirming feasibility and long‐term allograft survival under current immunosuppressive regimens. However, morbidity and mortality related to the adverse effects of the available immunosuppressive protocols are still high . Although lifelong immunosuppressive therapy is quite effective in preventing acute graft rejection, its efficacy in averting chronic rejection is not confirmed or well understood in VCA.…”

mentioning

confidence: 99%

The reversed paradigm of chimerism induction: Donor conditioning with recipient‐derived bone marrow cells as a novel approach for tolerance induction in vascularized composite allotransplantation

et al. 2016

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mentioning

confidence: 99%

The reversed paradigm of chimerism induction: Donor conditioning with recipient‐derived bone marrow cells as a novel approach for tolerance induction in vascularized composite allotransplantation

et al. 2016

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“…55 Infection is particularly important in the setting of induced immunosuppression to prevent rejection and may include surgical site infections, osteomyelitis, cytomegalovirus (CMV), herpes simplex virus (HSV), Clostridioides difficile, and human papillomavirus (HPV), among other opportunistic infections. [56][57][58][59]66,67 Significant infections have been reported in the literature in the early, intermediate, and late stages requiring hospitalization. A recent study found the incidence of infection to be higher after upper extremity VCA than after kidney transplantations during the early postoperative period but similar during the intermediate and late periods.…”

Section: Complicationsmentioning

confidence: 99%

Vascularized Composite Allograft Versus Prosthetic for Reconstruction After Facial and Hand Trauma

Noel,

Dumbrava,

Daoud

et al. 2023

Ann Plast Surg

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In the past decade, vascularized composite allotransplantation (VCA) has become clinical reality for reconstruction after face and hand trauma. It offers patients the unique opportunity to regain form and function in a way that had only been achieved with traditional reconstruction or with the use of prostheses. On the other hand, prostheses for facial and hand reconstruction have continued to evolve over the years and, in many cases, represent the primary option for patients after hand and face trauma. We compared the cost, associated complications, and long-term outcomes of VCA with prostheses for reconstruction of the face and hand/upper extremity. Ultimately, VCA and prostheses represent 2 different reconstructive options with distinct benefit profiles and associated limitations and should ideally not be perceived as competing choices. Our work adds a valuable component to the general framework guiding the decision to offer VCA or prostheses for reconstruction after face and upper extremity trauma.

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“…Alemtuzumab, a humanized mAb targeting CD52 (GPI-linked surface protein of mature lymphocytes) that causes B and T lymphocyte depletion, has been used in the prevention of SOT AR as well as in the treatment of VCA AR episodes ( 24 , 79 , 80 ). Basiliximab, a chimeric mAb specifically binding to interleukin-2 receptor, has been tested with promising results in SOT recipients and has also been used as induction therapy in VCA recipients ( 26 , 81 – 83 ).…”

Section: Alemtuzumab and Basiliximabmentioning

confidence: 99%

Costimulation Blockade in Vascularized Composite Allotransplantation

2020

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Vascular composite allotransplantation (VCA) is a field under research and has emerged as an alternative option for the repair of severe disfiguring defects that result from infections or traumatic amputation in a selected group of patients. VCA is performed in centers with appropriate expertise, experience and adequate resources to effectively manage the complexity and complications of this treatment. Lifelong immunosuppressive therapy, immunosuppression associated complications, and the effects of the host immune response in the graft are major concerns in VCA. VCA is considered a quality of life transplant and the risk-benefit ratio is dissimilar to life saving transplants. Belatacept seems a promising drug that prolongs patient and graft survival in kidney transplantation and it could also be an alternative approach to VCA immunosuppression. In this review, we are summarizing current literature about the role of costimulation blockade, with a focus on belatacept in VCA.

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Significant Infections After Hand Transplantation in a Polish Population

Cited by 10 publications

References 20 publications

The reversed paradigm of chimerism induction: Donor conditioning with recipient‐derived bone marrow cells as a novel approach for tolerance induction in vascularized composite allotransplantation

The reversed paradigm of chimerism induction: Donor conditioning with recipient‐derived bone marrow cells as a novel approach for tolerance induction in vascularized composite allotransplantation

Vascularized Composite Allograft Versus Prosthetic for Reconstruction After Facial and Hand Trauma

Costimulation Blockade in Vascularized Composite Allotransplantation

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