Significant Impact of Age on Mortality and Non-significant Impact of Age on Thrombosis and Major Bleeding in Patients with COVID-19: From the CLOT-COVID Study

Yamashita, Yugo; Yachi, Sen; Takeyama, Makoto; Nishimoto, Yuji; Tsujino, Ichizo; Nakamura, Junichi; Yamamoto, Naoto; Nakata, Hiroko; Ikeda, Satoshi; Umetsu, Michihisa; Aikawa, Shizu; Hayashi, Hiroya; Satokawa, Hirono; Okuno, Yoshinori; Iwata, Eriko; Ogihara, Yoshito; Ikeda, Nobutaka; Kondo, Akane; Iwai, Takehisa; Yamada, Norikazu; Ogawa, Tomohiro; Kobayashi, Takao; Mo, Makoto

doi:10.5551/jat.63702

Cited by 3 publications

(2 citation statements)

References 25 publications

(25 reference statements)

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“…Old age was reported to be a risk factor of mortality but not necessarily of thrombosis and major bleeding 57) . As for sex, men were reported to have more severe COVID-19 status than women, and the risk of developing thrombosis was reported to be higher in men than in women 58) .…”

Section: L I N I C a L Ev I D E N C E S O F T H R O M B O S I S A N D...mentioning

confidence: 99%

Thrombosis and Anticoagulation Strategies in Patients with COVID-19 Including Japanese Perspective

Yamashita

Kobayashi

2023

JAT

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Coronavirus disease 2019 (COVID-19) has become a major health problem worldwide since 2020.Although the main pathophysiology of COVID-19 is a respiratory infectious disease, it could also cause cardiovascular complications, including thrombosis. Thus, anticoagulation therapy has been thought to help prevent thrombosis, leading to improved survival. However, to date, several aspects of the optimal anticoagulation strategies for COVID-19 remain unclear. Considering the status of COVID-19-related thrombosis and some domestic issues in Japan, the optimal anticoagulation strategies for COVID-19 might have to be based on Japanese domestic clinical data considering racial difference. Racial disparities in terms of thromboembolic risk have been well known in the pre-COVID-19 era, and the risk of COVID-19-associated thrombosis depending on race could be an important issue. Considering a potential higher risk of bleeding with anticoagulation therapy in the Asian population, it might be important to maintain a good balance between the risks of thrombosis and bleeding. Latest evidences of COVID-19-related thrombosis and anticoagulation strategies, including some domestic issues in Japan, showed a different status of COVID-19-related thrombosis in Japan from that in Western countries, suggesting the potential benefit of different anticoagulation strategies, specifically for the Japanese population. Although these insights could be useful for the consideration of anticoagulation strategies for the Japanese population, the final decision should be based on balancing the benefits and risks of anticoagulation therapy in each patient.

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Section: L I N I C a L Ev I D E N C E S O F T H R O M B O S I S A N D...mentioning

confidence: 99%

Thrombosis and Anticoagulation Strategies in Patients with COVID-19 Including Japanese Perspective

Yamashita

Kobayashi

2023

JAT

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“…9) Thrombus development was associated with COVID-19 severity, and bleeding risk was related to COVID-19 severity and anticoagulation but not with age. [10][11][12] In patients with COVID-19, VTE, particularly pulmonary embolism (PE), may be a major cause of thrombosis. [13][14][15] However, there has been limited data on the detailed types of thrombosis, which could be important for understanding thrombosis associated with COVID-19.…”

Section: Introductionmentioning

confidence: 99%

Clinical Features Comparing Arterial Thrombosis and Venous Thromboembolism in Hospitalized Patients with COVID-19: Result from the CLOT-COVID Study

Umetsu

Kanamori

Murakami

et al. 2023

Annals of Vascular Diseases

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Objectives: This study aimed to investigate the clinical features of arterial thrombosis and venous thromboembolism (VTE) in coronavirus disease 2019 (COVID-19). Methods: The CLOT-COVID Study was a retrospective, multicenter cohort study that enrolled 2,894 consecutively hospitalized patients with COVID-19 among 16 centers in Japan from April 2021 to September 2021. We compared the clinical features of arterial thrombosis and VTE. Results: Thrombosis was observed in 55 patients (1.9%) during hospitalization. Arterial thrombosis and VTE occurred in 12 (0.4%) and 36 (1.2%) patients, respectively. Among the 12 patients with arterial thrombosis, 9 (75%), 2 (17%), and 1 developed ischemic cerebral infarction, myocardial infarction, and acute limb ischemia, respectively, and there were five patients (42%) without comorbidities. Among 36 patients with VTE, 19 (53%) and 17 (47%) developed pulmonary embolism (PE) and deep vein thrombosis (DVT), respectively. PE was common in the early stages of hospitalization; whereas, DVT was common beyond the early stages of hospitalization. Conclusion: Among patients with COVID-19, arterial thrombosis was less common than VTE, although ischemic cerebral infarction seemed to be relatively common, and a certain number of patients developed arterial thrombosis even in the absence of known atherosclerosis risk factors.

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Prevention of Venous Thromboembolism for COVID-19 Patients Based on Clinical Guidance of Prevention of Venous Thromboembolism in COVID-19 (Version 2.0)

Karube,

Mo,

Nemoto

et al. 2024

Jpn J Phlebol

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Significant Impact of Age on Mortality and Non-significant Impact of Age on Thrombosis and Major Bleeding in Patients with COVID-19: From the CLOT-COVID Study

Cited by 3 publications

References 25 publications

Thrombosis and Anticoagulation Strategies in Patients with COVID-19 Including Japanese Perspective

Thrombosis and Anticoagulation Strategies in Patients with COVID-19 Including Japanese Perspective

Clinical Features Comparing Arterial Thrombosis and Venous Thromboembolism in Hospitalized Patients with COVID-19: Result from the CLOT-COVID Study

Prevention of Venous Thromboembolism for COVID-19 Patients Based on Clinical Guidance of Prevention of Venous Thromboembolism in COVID-19 (Version 2.0)

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