Significant elevation and correlation of plasma neutrophil gelatinase associated lipocalin and its complex with matrix metalloproteinase-9 in patients with pelvic inflammatory disease

Tsai, Hsiu Ting; Su, Pen Hua; Lee, Tsung-Hsien; Tee, Yi Torng; Lin, Long Yau; Yang, Shun Fa; Wang, Po Hui

doi:10.1016/j.cca.2011.03.021

Cited by 18 publications

(12 citation statements)

References 27 publications

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“…The expression of unbound NGAL is upregulated in several acute and chronic inflammatory diseases whereas the role of the NGAL/MMP‐9 complex in the pathogenesis of inflammatory diseases needs a better elucidation . However, the increasing, even though not significant, trend in the level of the NGAL/MMP‐9 complex during T. spiralis infection, could be in agreement with results obtained in some inflammatory diseases .…”

Section: Discussionsupporting

confidence: 80%

Matrix metalloproteinase (MMP)‐2 and MMP‐9 as inflammation markers of Trichinella spiralis and Trichinella pseudospiralis infections in mice

Bruschi

Bianchi

Fornaro

et al. 2014

Parasite Immunology

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Trichinella spiralis and Trichinella pseudospiralis exhibit differences in the host-parasite relationship such as the inflammatory response in parasitized muscles. Several studies indicate that matrix metalloproteinases (MMPs) represent a marker of inflammation since they regulate inflammation and immunity. The aim of this study was to evaluate the serum levels of gelatinases (MMP-9 and MMP-2) in mice experimentally infected with T. spiralis or T. pseudospiralis, to elucidate the involvement of these molecules during the inflammatory response to these parasites. Gelatin zymography on SDS polyacrilamide gels was used to assess the serum levels and in situ zymography on muscle histological sections to show the gelatinase-positive cells. In T. spiralis infected mice, the total MMP-9 serum level increased 6 days post-infection whereas, the total MMP-2 serum level increased onward. A similar trend was observed in T. pseudospiralis infected mice but the MMP-9 level was lower than that detected in T. spiralis infected mice. Significant differences were also observed in MMP-2 levels between the two experimental groups. The number of gelatinase positive cells was higher in T. spiralis than in T. pseudospiralis infected muscles. We conclude that MMP-9 and MMP-2 are markers of the inflammatory response for both T. spiralis and T. pseudospiralis infections.

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Section: Discussionsupporting

confidence: 80%

Matrix metalloproteinase (MMP)‐2 and MMP‐9 as inflammation markers of Trichinella spiralis and Trichinella pseudospiralis infections in mice

Bruschi

Bianchi

Fornaro

et al. 2014

Parasite Immunology

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“…Along with the previous report that the enzymatic activity of urinary MMP-9/lipocalin-2 complex is detected in the urine of breast cancer patients but not in healthy control [11], several studies have suggested that circulating MMP-9, lipocalin-2 and MMP-9/lipocalin-2 complex could serve as a diagnostic and/or a prognostic biomarker in a variety of diseases with different suggested mechanisms [12-15]. In breast cancer, only one study has reported the positive association between the serum level of lipocalin-2/MMP-9 complex and disease status [16].…”

Section: Introductionmentioning

confidence: 99%

The association between the preoperative serum levels of lipocalin-2 and matrix metalloproteinase-9 (MMP-9) and prognosis of breast cancer

et al. 2012

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BackgroundAlthough a number of experimental studies have suggested the role of lipocalin-2 (LCN2) and matrix metalloproteinase-9 (MMP-9) in breast cancer progression, limited numbers of epidemiological studies have examined the relationship between the levels of lipocalin-2 and MMP-9 and breast cancer survival.MethodsPreoperative serum levels of lipocalin-2 and MMP-9 were measured in 303 breast cancer patients and 74 healthy controls recruited between 2004 and 2007. We examined the association between lipocalin-2 and MMP-9 levels and disease-free survival (DFS) using Cox proportional hazard regression model.ResultsThe serum levels of lipocalin-2 and MMP-9 were not significantly different between patients and controls (P > 0.05). Elevated lipocalin-2 and MMP-9 levels were associated with reduced DFS of breast cancer ( Ptrend = 0.029 and Ptrend = 0.063, respectively). When lipocalin-2 and MMP-9 levels were categorized based on the combined risk score, patients with higher levels of both lipocalin-2 and MMP-9 exhibited poor DFS compared to patients with lower levels (Ptrend = 0.004). Furthermore, these effects were profound in patients with BMI less than 25 kg/m2 (adjusted hazard ratio (aHR), 3.17; 95% confidence intervals (CI), 1.66-6.06, Ptrend < 0.001) or lymph-node negative breast cancer (aHR, 5.36; 95% CI, 2.18-13.2, Ptrend < 0.001).ConclusionsOur study suggests that the elevated levels of lipocalin-2 and MMP-9 are associated with reduced breast cancer survival, particularly in patients with lower BMI and lymph-node negative breast cancers.

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“…Moreover, LCN2 has been reported to be upregulated in epithelial tissues during inflammation, and it seems to play an important role in this process . This protein is also upregulated in several pathological conditions, including cancers , inflammatory bowel disease , acute kidney injury (AKI; ), autoimmune myocarditis , arthritis , pelvic inflammatory disease (PID; ), bacterial pneumonia , sepsis , and pancreatitis . Several studies have shown LCN2 to be a useful biomarker for the early detection of AKI in postcardiac surgery, nephritis, and radiocontrast exposure .…”

Section: Introductionmentioning

confidence: 99%

“…Recent findings have suggested that detection of the LCN2/MMP‐9 complex might represent a predictor of disease status or of therapeutic response in several types of cancer, including breast , brain , gastric , and oral cancers. Moreover, LCN2/MMP‐9 complex was also proved to act as a diagnostic biomarker for PID .…”

Section: Introductionmentioning

confidence: 99%

Circulating Level of Lipocalin 2 As a Predictor of Severity in Patients With Community‐Acquired Pneumonia

Yeh¹,

Chang²,

Hsiao³

et al. 2013

Clinical Laboratory Analysis

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Significant elevation and correlation of plasma neutrophil gelatinase associated lipocalin and its complex with matrix metalloproteinase-9 in patients with pelvic inflammatory disease

Cited by 18 publications

References 27 publications

Matrix metalloproteinase (MMP)‐2 and MMP‐9 as inflammation markers of Trichinella spiralis and Trichinella pseudospiralis infections in mice

Matrix metalloproteinase (MMP)‐2 and MMP‐9 as inflammation markers of Trichinella spiralis and Trichinella pseudospiralis infections in mice

The association between the preoperative serum levels of lipocalin-2 and matrix metalloproteinase-9 (MMP-9) and prognosis of breast cancer

Circulating Level of Lipocalin 2 As a Predictor of Severity in Patients With Community‐Acquired Pneumonia

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