Significant Differentiation of Focal Breast Lesions: Raw Data-Based Calculation of Strain Ratio

Fischer, Thomas; Peisker, U.; Fiedor, S.; Slowinski, Torsten; Wedemeyer, Phillips P.; Diekmann, Felix; Grigoryev, Maria; Thomas, Anke

doi:10.1055/s-0031-1273222

Cited by 67 publications

(37 citation statements)

References 11 publications

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“…The ratio of the fatty tissue strain a to the tumor strain b can then be calculated offline. b The strain ratio of 1.62 is significantly less than the cut-off value of 2.27 [33]. This also confirms the histologically verified fibroadenoma from • " Fig.…”

Section: Bi-rads-us Criteriasupporting

confidence: 67%

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Characterization of Focal Breast Lesions by Means of Elastography

Fischer

Sack

Thomas

2013

Fortschr Röntgenstr

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Purpose: The modern method of sonoelastography of the breast is used for differentiating focal lesions. This review gives an overview of the different techniques available and discusses their roles in the routine clinical setting. Materials and Methods: The presented techniques include compression or vibration elastography as well as shear wave elastography. Descriptions of the methods are supplemented by a discussion of the clinical role of each technique based on the most recent literature. We discuss by outlining two recent experimental approaches ? MRI and tomosynthesis elastography. Results: Currently available data suggest that elastography is an important supplementary tool for the differentiation of breast tumors under routine clinical conditions. The specificity improves with the immediate availability of additional diagnostic information using real-time techniques and/or the calculation of strain ratios (SR). Elastography is especially helpful in women with involuted breasts for differentiating BI-RADS-US 3 and 4 lesions and for evaluating very small cancers without the typical imaging features of malignancy. Here, elastography techniques are highly specific, while the sensitivity decreases compared to B-mode ultrasound. SR calculation is especially helpful in women who have a high risk of breast cancer and high pretest likelihood. Conclusion: B-mode ultrasound is still the first-line method for the initial evaluation of the breast. If suspicious findings are detected, elastography with or without SR calculation is the most crucial supplementary tool. Key Points: Citation Format:

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Section: Bi-rads-us Criteriasupporting

confidence: 67%

“…3b-e). In a European patient collective, this value was 2.455 using Hitachi equipment [15] and 2.27 using Toshiba equipment [33]. Since the cut-off value can differ depending on the country, e. g. a cut-off value of 3.05 was calculated in China [34], there are no standardized limit values.…”

Section: üBersicht 819mentioning

confidence: 99%

Characterization of Focal Breast Lesions by Means of Elastography

Fischer

Sack

Thomas

2013

Fortschr Röntgenstr

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“…[27][28][29] However, normal testicular tissues were compared with pathological lesions in those studies. In contrast, we defined two ROIs as middle of testis (A) and subcutaneous fatty tissue of corresponding scrotum (B) in this study.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the diagnostic efficacy of strain elastography in infertile population with normal and abnormal semen parameters

Küçükdurmaz

Sarıca

Emre

et al. 2017

Turkish Journal of Urology

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Objective: The aim of the present study was to investigate the diagnostic value of strain elastography (SE) of testicular tissues in infertile population. We also evaluated the correlation between SE results with semen parameters and hormone profiles of the patients. Material and methods:A total of 61 patients and 122 testes were evaluated. Patients who were evaluated in an andrology outpatient clinic with the diagnosis of infertility and referred to radiology department for investigation of reproductive organs between June 2015 and January 2016 were included. Patients were divided into two groups according to semen analyses results as normal (Group 1) and abnormal (Group 2). Hormone profiles, semen analyses, B-mode, coloured Doppler ultrasonography and sonoelastography examinations were performed for each patient. Measurements of testicular volumes, resistive indices (RI) in intraparenchymal arteries, strain, strain ratio (SR) and presence of varicocele were recorded.Results: Mean age of participants was 33.7±6.3 years. Mean testicular volumes (Group 1, 19.41±4.8 mL, and Group 2, 17.64±3.62 mL) were significantly different between groups (p= 0.023). Mean SRs were also different between Groups 1 and 2 (0.12±0.08 vs. 0.22±0.18, p<0.001). Testicular volumes were directly proportional with SRs in Group 1. Strain values had inverse relationship with sperm concentration and total motile sperm counts in Group 2 (p= 0.01). SRs were found to be positively correlated with RI and sperm morphology in Group 2 (p<0.05). Although FSH values showed significant difference among groups, any correlation between FSH and elastographic parameters could not be displayed. Conclusion:Strain elastography results were found to be significantly different in patients with abnormal sperm counts. This technique may provide promising results, however, further large scale studies may help to clarify the value of this imaging modality in the assessment of male infertility.

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“…The strain ratio (SR) was introduced since USE is an examiner-dependent freehand technique, and additionally because benign changes such as inflammation or fibrosis with hardening can affect the USE [20,21]. This is a semiquantitative measurement procedure with which relative elasticity values of lesions are generated.…”

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confidence: 99%

“…The fatto-lesion ratio (FLR) was established in which the strain of the fat tissue (= reference tissue) of the breast is compared the strain of the lesion. European studies determined cutoff values of 2.27 -2.455, depending on the technical equipment used, to differentiate between benign and malignant focal lesions [20,21]. FLR appears to be a highly-significant …”

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confidence: 99%

Strain Elastography of Breast and Prostata Cancer: Similarities and Differences

Daniaux

Auer

Zordo

et al. 2015

Fortschr Röntgenstr

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Typically both breast and prostate cancer present as tissue with decreased elasticity. Palpation is the oldest technique of tumor detection in both organs and is based on this principle. Thus an operator can grade a palpable mass as suspicious for cancer. Strain elastography as modern ultrasound technique allows the visualization of tissue elasticity in a color coded elastogram and can be understood as technical finger. The following article shows similarities and differences of ultrasound strain elastography in the diagnosis of breast and prostate cancer. Key Points: ??In prostata cancer elastography, in breast cancer B-mode is the primary sonographic search modality. ??The diagnostic value of the search modalities change with increasing age. ??A cut-off value for a strain ratio is hard to obtain in the elastography of the prostata, because there is no stabile reference tissue in the prostata. Citation Format: ??Daniaux M, Auer T, De Zordo T et?al. Strain Elastography of Breast and Prostata Cancer: Similarities and Differences. Fortschr R?ntgenstr 2016; 188: 1???6

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Significant Differentiation of Focal Breast Lesions: Raw Data-Based Calculation of Strain Ratio

Abstract: Strain ratio calculation contributes to the standardization of sonoelastography with high sensitivity and allows significant differentiation between benign and malignant breast lesions with a higher specificity compared to B-mode, subjective evaluation of elastography and mammography.

Cited by 67 publications

References 11 publications

Characterization of Focal Breast Lesions by Means of Elastography

Characterization of Focal Breast Lesions by Means of Elastography

Evaluation of the diagnostic efficacy of strain elastography in infertile population with normal and abnormal semen parameters

Strain Elastography of Breast and Prostata Cancer: Similarities and Differences

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