Significant Differences in the Bacterial Microbiome of the Pharynx and Skin in Patients with Psoriasis Compared with Healthy Controls

Abstract

Studies have shown differences in the skin and gut bacterial microbiomes in patients with psoriasis, but the pharyngeal microbiome has not been studied previously. The aim of this study was to investigate differences in the bacterial microbiome of the pharynx and skin of patients with psoriasis compared with healthy controls. Swabs were taken from the pharynx and elbow skin of 39 patients with psoriasis and 70 controls. Microbiomes were characterized by sequencing 16S rRNA genes on the Illumina MiSeq platform. Significant differences were found in alpha and beta diversity in the skin, but not in the pharynx. Significant differences were also found between several phyla and genera in both skin and pharynx. The severity of psoriasis did not correlate with any genera in the pharynx, but with Capnocytophaga , Leptotrichia , Abiotrophia and Tannerella in the skin. The composition of the pharyngeal and skin microbiome may be of importance in the pathogenesis of psoriasis.

Microbiota differences of skin and pharyngeal microbiota between patients with plaque and guttate psoriasis in China

“…Similar to other previous studies of psoriasis skin composition ( Alekseyenko et al, 2013 ; Chang et al, 2018 ), our results showed the three commonest prominent phyla in psoriatic skin: Proteobacteria , Firmicutes , and Actinobacteria . In the psoriatic pharyngeal habitat, the majority of bacteria were identified within the phyla Firmicutes and Bacteroidetes , in agreement with previous studies ( Assarsson et al, 2020 ).…”

“…The microbiota of the skin or pharynx of patients with psoriasis and healthy controls has already been demonstrated to differ significantly ( Assarsson et al, 2020 ; Olejniczak-Staruch et al, 2021 ). In order to investigate the microbiota community structure of patients with PP and GP, we examined the relative abundances of LPP, SPP, and GP samples by stacked bar plots to determine the predominant composition among these groups ( Supplementary Figures 3A,D ).…”

“…Furthermore, a study suggested that in patients with PP, IgA plasma levels against S. pyogenes were correlated with cutaneous lymphocyte-associated antigen + T-cell-dependent IL-17F response in vitro (De JESús-Gil et al, 2020). However, significant alpha-and beta-diversity differences in pharyngeal microbiota were not detected between patients with psoriasis and healthy controls in another recent study (Assarsson et al, 2020).…”

“…Evidence linking skin and pharyngeal microbiota dysbiosis to chronic inflammation and immune system-mediated diseases has been expanding ( Paller et al, 2019 ; Assarsson et al, 2020 ; Marazzato et al, 2020 ; Liang et al, 2021 ). In this study, we aimed to delineate the community structure of the skin and pharyngeal microbiome from patients with PP (subtype LPP and SPP) and GP through 16S rRNA gene sequencing.…”

Decrypting Skin Microbiome in Psoriasis: Current Status

“…After assessing the full text, 1 more study also has been excluded as it explains more about faecal microbiota translational research in psoriasis-like inflammation in mice and did not accord with the objective of present meta-study. Therefore, we reviewed twenty research articles (PMID: 33796091, 21 24451201, 22 18648509, 23 29199351, 24 26811697, 25 16891514, 26 25510344, 27 32945341, 28 31619666, 29 32852562, 30 30185226, 15 30985920, 31 29559344, 32 26659932, 33 22065152, 34 28649415, 35 24018484, 36 31247199, 37 31228520, 38 32486022 16 ) thoroughly that focus on skin microbiota dysbiosis of the lesional and normal psoriatic skin.…”