Significant decrease of adenocarcinoma in situ not reflected in cervical adenocarcinoma incidence in the Netherlands 1989–2003

Nieuwenhof, H.P. van de; Massuger, Leon F.A.G.; Hullu, Joanne A. de; Ham, Maaike A.P.C. van; Dijck, J.A.A.M. van; Siebers, Albertus G.; Bekkers, Ruud L.M.

doi:10.1038/sj.bjc.6604118

Cited by 10 publications

(5 citation statements)

References 33 publications

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“…The increase in AIS was predominant in women in the 25–39 age groups. This finding is not in accordance with the trends found by van de Nieuwenhof et al ,. who described a decrease in the adenocarcinoma in situ incidence with a stable adenocarcinoma incidence in the period of 1989–2003.…”

Section: Discussioncontrasting

confidence: 98%

“…By using the Dutch national pathology database (PALGA) and scrutinizing all records with the specific terms mentioned as mentioned above, we are convinced that our dataset is more complete. This can partly explain the difference between this study and the study by van de Nieuwenhof .…”

Section: Discussioncontrasting

confidence: 93%

“…The incidence of cervical adenocarcinoma remained relatively stable or increased, predominantly caused by an increasing incidence in younger women . This differed for the precursor lesions as in 1987–2003 a decreasing incidence of adenocarcinoma in situ (AIS) was found .…”

Section: Introductionmentioning

confidence: 98%

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Increasing incidence of invasive and in situ cervical adenocarcinoma in the Netherlands during 2004–2013

et al. 2017

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In the developed world, the incidence of cervical squamous cell carcinoma has decreased, however, the incidence of adenocarcinoma in situ (AIS) and invasive adenocarcinoma increased, predominantly in young females. The goal of this study was to evaluate the most recent incidence rates of AIS, adenocarcinoma, and squamous cell carcinoma of the uterine cervix in the Netherlands in [2004][2005][2006][2007][2008][2009][2010][2011][2012][2013]. By using Dutch national pathology and cancer registries, we calculated European standardized incidence rates ( Of these AIS cases, 58.9% had concomitant CIN and AIS with concomitant CIN showed a significantly higher EAPC compared to AIS without CIN. Our conclusion is that despite a nationwide screening program for cancer of the uterine cervix, the incidence of adenocarcinoma in the Netherlands remained stable during 2004-2013 and the incidence of adenocarcinoma in situ increased. This was most predominant in cases with concomitant CIN and in younger females. The incidence of squamous cell carcinoma decreased in the same timeframe. Cancer Medicine Open Access 417

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Section: Discussioncontrasting

confidence: 98%

Section: Discussioncontrasting

confidence: 93%

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Increasing incidence of invasive and in situ cervical adenocarcinoma in the Netherlands during 2004–2013

et al. 2017

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“…There have been some studies to date which have examined risk factors for, incidence trends of, HPV prevalence in adenocarcinoma. However, most of these studies were based on pooled analyses of data from epidemiological studies,4, 11 extraction of data from cancer registries5, 12–14 or retrospective collection and examination of archival tissue 15–22. The peak age of incidence of AIS among women has been estimated as 35–39 years, and the duration of progression from AIS to adenocarcinoma has been estimated to be 5–13 years 7.…”

mentioning

confidence: 99%

Adenocarcinoma in situ and associated human papillomavirus type distribution observed in two clinical trials of a quadrivalent human papillomavirus vaccine

Ault¹,

Joura²,

Kjær³

et al. 2011

Intl Journal of Cancer

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The primary objective of this report is to describe the detection of adenocarcinoma in situ (AIS) and associated human papillomavirus (HPV) type distribution that was observed in the context of two phase 3 clinical trials of a quadrivalent HPV6/11/ 16/18 vaccine. In this intention-to-treat analysis, we include all women who had at least one follow-up visit postenrollment. Healthy women (17,622) aged 15-26 with no history of HPV disease and a lifetime number of less than five sex partners

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“…Precancerous stages of adenocarcinoma are less clearly understood and may not be as long as for squamous carcinoma. Indeed, some authors have argued that the lack of correlation between in situ disease and changes in adenocarcinoma rates implies that screening may have no impact on adenocarcinoma rates 25–27. Our results suggest that screening has a small but significant impact on the incidence of adenocarcinoma.…”

Section: Discussionmentioning

confidence: 53%

Adaptation of retrovirus producer cells to serum deprivation: Implications in lipid biosynthesis and vector production

Rodrigues¹,

Amaral²,

Veríssimo³

et al. 2012

Biotech & Bioengineering

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The manufacture of enveloped virus, particularly retroviral (RV) and lentiviral (LV) vectors, faces the challenge of low titers that are aggravated under serum deprivation culture conditions. Also, the scarce knowledge on the biochemical pathways related with virus production is still limiting the design of rational strategies for improved production yields. This work describes the adaptation to serum deprivation of two human RV packaging cell lines, 293 FLEX and Te Fly and its effects on lipid biosynthetic pathways and infectious vector production. Total lipid content as well as cellular cholesterol were quantified and lipid biosynthesis was assessed by (13)C-NMR spectroscopy; changes in gene expression of lipid biosynthetic enzymes were also evaluated. The effects of adaptation to serum deprivation in lipid biosynthesis were cell line specific and directly correlated with infectious virus titers: 293 FLEX cells faced severe lipid starvation-up to 50% reduction in total lipid content-along with a 68-fold reduction in infectious vector titers; contrarily, Te Fly cells were able to maintain identical levels of total lipid content by rising de novo lipid biosynthesis, particularly for cholesterol-50-fold increase-with the consequent recovery of infectious vector productivities. Gene expression analysis of lipid biosynthetic enzymes further confirmed cholesterol production pathway to be prominently up-regulated under serum deprivation conditions for Te Fly cells, providing a genotype-phenotype validation for enhanced cholesterol synthesis. These results highlight lipid metabolism dynamics and the ability to activate lipid biosynthesis under serum deprivation as an important feature for high retroviral titers. Mechanisms underlying virus production and its relationship with lipid biosynthesis, with special focus on cholesterol, are discussed as potential targets for cellular metabolic engineering.

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Significant decrease of adenocarcinoma in situ not reflected in cervical adenocarcinoma incidence in the Netherlands 1989–2003

Abstract: Over the period 1989 -2003, the incidence of cervical adenocarcinoma (n ¼ 1615) was stable whereas that of cervical adenocarcinoma in situ (n ¼ 1884) significantly decreased (P ¼ 0.008), mainly caused by adenocarcinoma in situ lesions with a concurrent squamous dysplasia.

Cited by 10 publications

References 33 publications

Increasing incidence of invasive and in situ cervical adenocarcinoma in the Netherlands during 2004–2013

Increasing incidence of invasive and in situ cervical adenocarcinoma in the Netherlands during 2004–2013

Adenocarcinoma in situ and associated human papillomavirus type distribution observed in two clinical trials of a quadrivalent human papillomavirus vaccine

Adaptation of retrovirus producer cells to serum deprivation: Implications in lipid biosynthesis and vector production

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