Significant correlations of plasma homocysteine and serum methylmalonic acid with movement and cognitive performance in elderly subjects but no improvement from short-term vitamin therapy: a placebo-controlled randomized study

Lewerin, Catharina; Matousek, Michael; Steen, Göran O.; Johansson, Boo; Steen, Bertil; Nilsson‐Ehle, Herman

doi:10.1093/ajcn/81.5.1155

Cited by 113 publications

(77 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Many of these trials however were of insufficient power and duration to detect an effect or included participants with existing optimal B-vitamin status or with advanced dementia, where a beneficial effect is not likely (60,62,(67)(68)(69)(70) . Notably, two similarly designed homocysteine-lowering trials have yielded conflicting results.…”

Section: Evidence Linking B-vitamins With Brain Health In Ageingmentioning

confidence: 99%

Emerging roles for folate and related B-vitamins in brain health across the lifecycle

et al. 2014

View full text Add to dashboard Cite

Nutrition plays a fundamental role in supporting the structural and functional development of the human brain from conception, throughout early infancy and extending into later life. A growing body of evidence suggests that folate and the metabolically related B-vitamins are essential for brain health across all age groups, owing to their specific roles in C 1 metabolism and particularly in the production of S-adenosylmethionine, a universal methyl donor essential for the production of neurotransmitters. Emerging, though not entirely consistent, evidence suggests that maternal folate status throughout pregnancy may influence neurodevelopment and behaviour of the offspring. Furthermore optimal B-vitamin status is associated with better cognitive health in ageing. Of note, a recent clinical trial provided evidence that supplementation with folic acid and related B-vitamins over a 2-year-period reduced global and regional brain atrophy, as measured by MRI scan in older adults. In terms of potential mechanisms, the effects of these B-vitamins on cognitive health may be independent or may be mediated by nutrient-nutrient and/or relevant gene-nutrient interactions. Furthermore, a new area of research suggests that the in utero environment influences health in later life. Folate, an important cofactor in C 1 metabolism, is indirectly involved in DNA methylation, which in turn is considered to be one of the epigenetic mechanisms that may underlie fetal programming and brain development. The present review will explore the evidence that supports a role for folate and the related B-vitamins in brain health across the lifecycle, and potential mechanisms to explain such effects.

show abstract

Section: Evidence Linking B-vitamins With Brain Health In Ageingmentioning

confidence: 99%

Emerging roles for folate and related B-vitamins in brain health across the lifecycle

et al. 2014

View full text Add to dashboard Cite

show abstract

“…The factors that contribute to the malabsorption of food cobalamin include chronic presence of Helicobacter pylori, achlorhydria and intestinal microbial proliferation, which can be brought on by antibiotic treatment (3,5) . In patients with pernicious anaemia, studies of methylmalonic acid (MMA) and homocysteine values compared with vitamin B 12 levels have determined that metabolites are elevated prior to the development of any clinical abnormalities and often prior to abnormal serum vitamin B 12 concentrations (6) . A correct diagnosis of vitamin B 12 deficiency is complicated due to the poor sensitivity and specificity of conventional kit assays (7) .…”

mentioning

confidence: 99%

High frequency of vitamin B₁₂ deficiency in a Brazilian population

Xavier

Costa

Annichino‐Bizzacchi

et al. 2010

Public Health Nutr.

View full text Add to dashboard Cite

Objective: There are few studies regarding vitamin B 12 deficiency in developing countries. In Brazil, a late diagnosis of vitamin B 12 deficiency progressing to severe neurological damage is common. Thus, the aim of the present study was to verify the frequency of vitamin B 12 deficiency in two Brazilian populations (elderly and adult participants) and to compare different methods of vitamin B 12 deficiency detection. Design: Five hundred participants were recruited from health centres from south-east Brazil and were separated into two groups: 60 years old or more and 30-59 years old. Vitamin B 12 and folate concentrations were measured using electrochemiluminescence immunoassay (ECI) and RIA. Methylmalonic acid (MMA) was measured by LC coupled to tandem MS. Full blood counts were acquired using standard methods. Results: All participants had normal blood count results and mean cell volume less than 99 fl; none of them presented folate deficiency according to the results, which were all greater than 3 ng/ml. Cobalamin levels less than 200 pmol/l were identified by one of the two or by both methods in 7?2 % of the participants aged 60 years or more and 6?4 % of the participants aged 30-59 years. MMA levels were higher in older subjects (P 5 0?007) compared with younger subjects. A greater correlation of MMA v. RIA was observed than of MMA v. ECI (P 5 0?0017 v. P 5 0?014). MMA quantification estimated that cobalamin deficiency was present in more than 11 % of the subjects for both studied groups. Conclusions: The study shows that vitamin B 12 deficiency is frequent in Brazilian adults and suggests that RIA is more sensitive than ECl for measuring cobalamin levels.

show abstract

“…Hasil tersebut sejalan dengan penelitian yang dilakukan di Kanada untuk 9008 subjek berusia di atas 65 tahun. Penelitian yang dilakukan oleh Lewerin (2005) menunjukkan adanya hubungan yang signifikan antara subjek yang memiliki aktivitas fisik dan yang tanpa aktivitas fisik dengan kejadian demensia.…”

Section: Riwayat Penyakitunclassified

Pola Konsumsi Pangan, Aktivitas Fisik, Riwayat Penyakit, Riwayat Demensia Keluarga, Dan Kejadian Demensia Pada Lansia Di Panti Werdha Tresna Bogor

2014

View full text Add to dashboard Cite

Keywords: cognitive, dementia, memory, patterns of consumption, physical activity ABSTRAKPenelitian ini bertujuan untuk menganalisis pola konsumsi pangan, aktivitas fisik, riwayat penyakit, riwayat demensia keluarga, dan kejadian demensia pada lansia di Panti Werdha Tresna, Bogor. Desain penelitian ini adalah cross sectional dengan subjek penelitian sebanyak 42 lansia. Hasil penelitian menunjukkan bahwa terdapat hubungan yang signifikan antara tingkat pendidikan, tingkat kecukupan vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, riwayat penyakit diabetes mellitus, dan aktivitas fisik dengan kejadian demensia pada lansia (p<0.05). Tidak terdapat hubungan yang signifikan antara usia, tingkat kecukupan asam folat, riwayat hipertensi, dan riwayat demensia keluarga dengan kejadian demensia pada lansia (p>0.05).

show abstract

Significant correlations of plasma homocysteine and serum methylmalonic acid with movement and cognitive performance in elderly subjects but no improvement from short-term vitamin therapy: a placebo-controlled randomized study

Cited by 113 publications

References 50 publications

Emerging roles for folate and related B-vitamins in brain health across the lifecycle

Emerging roles for folate and related B-vitamins in brain health across the lifecycle

High frequency of vitamin B₁₂ deficiency in a Brazilian population

Pola Konsumsi Pangan, Aktivitas Fisik, Riwayat Penyakit, Riwayat Demensia Keluarga, Dan Kejadian Demensia Pada Lansia Di Panti Werdha Tresna Bogor

Contact Info

Product

Resources

About

Significant correlations of plasma homocysteine and serum methylmalonic acid with movement and cognitive performance in elderly subjects but no improvement from short-term vitamin therapy: a placebo-controlled randomized study

Cited by 113 publications

References 50 publications

Emerging roles for folate and related B-vitamins in brain health across the lifecycle

Emerging roles for folate and related B-vitamins in brain health across the lifecycle

High frequency of vitamin B12 deficiency in a Brazilian population

Pola Konsumsi Pangan, Aktivitas Fisik, Riwayat Penyakit, Riwayat Demensia Keluarga, Dan Kejadian Demensia Pada Lansia Di Panti Werdha Tresna Bogor

Contact Info

Product

Resources

About

High frequency of vitamin B₁₂ deficiency in a Brazilian population