Significant Coronary Calcification Detected Using Contrast-Enhanced Computed Tomography

Gayed, Isis; Raslan, Osama; Bhosale, Priya; Perrier, Nancy D.; Wei, Wei; Gladish, Gregory W.

doi:10.1097/rlu.0b013e3181db4ad6

Cited by 3 publications

(2 citation statements)

References 23 publications

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“…CT scans were performed on commercially available multi-detector CTs with methods as previously described [ 10 ]. Briefly, images were non-ECG gated thoracic CT scans with or without contrast enhancement as clinically indicated [ 8 , 18 ]. Soft tissue kernel slice-thickness images ranged from 1.0–5.0 mm and were acquired using Aquillon 16-, 64-, 320-detector (Toshiba Canada Medical Systems Limited, Markham, Ontario); Lightspeed Plus 16- and Lightspeed 64-detector (General Electric Healthcare, Mississauga, Ontario,) and Definition Flash dual source 64 × 2-detector Siemens Medical Solutions Canada, Oakville, Ontario).…”

Section: Methodsmentioning

confidence: 99%

Reporting of coronary artery calcification on chest CT studies in breast cancer patients at high risk of cancer therapy related cardiac events

Phillips

Johnson

Law

et al. 2018

IJC Heart & Vasculature

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BackgroundThe identification of coronary artery calcification (CAC) detected coincidentally on chest CT exams could assist in cardiovascular risk assessment but may not be reported consistently on clinical studies. Cardiovascular risk factor stratification is important to predict short term cardiac events during cancer therapy and long term cardiac event free survival in cancer patients. We sought to determine the prevalence of CAC and clinical reporting rates in a cohort of cancer patients at high risk of cancer therapy related cardiac events.Methods408 Breast cancer patients who were referred to a cardiac oncology clinic were screened. Inclusion criteria included having had a CT chest and the absence of known coronary disease. Among those screened 263 patients were included in the study.ResultsCAC was identified in 70 patients (26%). CAC was reported in 18% of studies. The reporting rates of CAC increased with the extent of coronary calcification (p < 0.01) and increased during the period of the study (p < 0.05).ConclusionsCAC was commonly detected on chest CT studies in this observational study of breast cancer patients at high risk of cardiac oncology events. The presence of CAC was often not reported clinically but reporting rates have increased over time. Recent SCCT/STR guidelines recommend reporting the presence of CAC on routine chest CT scans in recognition of the importance of CAC as a predictor of cardiovascular events. Reporting of CAC on chest CTs may help to further risk stratify breast cancer patients and improve cardiovascular outcomes in this vulnerable population.

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Section: Methodsmentioning

confidence: 99%

Reporting of coronary artery calcification on chest CT studies in breast cancer patients at high risk of cancer therapy related cardiac events

Phillips

Johnson

Law

et al. 2018

IJC Heart & Vasculature

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show abstract

“…1), including electron beam tomography or multidetector CT. CT scans can be used as a noninvasive tool to quantify and determine the anatomic distribution of CAC and provide a calcification score, which is a precise number that provides information about cardiac risk by assessment of the total atherosclerotic plaque burden and the amount of plaque volume. Published studies demonstrate a high sensitivity of CAC score for the presence of CAD but a lower specificity for obstructive CAD [16][17][18].…”

Section: Cac Score For Risk Stratification and As A Screening Testmentioning

confidence: 99%

Coronary Artery Calcification Score and Computed Tomographic Coronary Angiography: A Review and Update

Abu-El-Haija¹

2012

TOATHERTJ

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Coronary artery disease (CAD) is the leading cause of death in the United States and the world. Identifying new risk factors and improving the screening methods for CAD are continuously evolving processes. The coronary artery calcification (CAC) score, as measured by computed tomographic coronary angiography (CTCA) is of intense interest to clinicians and investigators because of its potential role for diagnosis, risk stratification, and prediction of future mortality and morbidity. Recent studies demonstrate the substantial significance of CAC in CAD and its usefulness as a predictive variable. CAC is a marker of atherosclerosis and gives an estimate of disease severity and extent. It has the potential to provide an objective or quantitative measure of CAD. CTCA offers a noninvasive methodology for defining coronary artery anatomy and providing further definition of CAD extent and severity. Understanding the significance, current role, recent discoveries, and applications of CAC and CTCA is of paramount importance for improved diagnosis and profiling of suspected ischemic heart disease.

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Comparison of Framingham risk score and chest-CT identified coronary artery calcification in breast cancer patients to predict cardiovascular events

Phillips

Johnson

Law

et al. 2019

International Journal of Cardiology

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Significant Coronary Calcification Detected Using Contrast-Enhanced Computed Tomography

Abstract: Multiple diffuse CAC as detected during the interpretation of CECCT scans in combination with advanced age is a significant finding that warrants further investigation for functionally significant CAD.

Cited by 3 publications

References 23 publications

Reporting of coronary artery calcification on chest CT studies in breast cancer patients at high risk of cancer therapy related cardiac events

Reporting of coronary artery calcification on chest CT studies in breast cancer patients at high risk of cancer therapy related cardiac events

Coronary Artery Calcification Score and Computed Tomographic Coronary Angiography: A Review and Update

Comparison of Framingham risk score and chest-CT identified coronary artery calcification in breast cancer patients to predict cardiovascular events

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