Significant Changes in Trans-Epithelial Barrier Proteins of Adenoid Tissue with Atopic Status in Children

The Impact of Environmental Pollutants on Barrier Dysfunction in Respiratory Disease

“… 36 Subjects from 5 to 15 years old whom were sensitized to environmental allergens demonstrate that the levels for occludin, CLDN, ZO-1, e-cadherin and β catenin of intra-epithelial junctional proteins in the lymphoepithelium of the adenoid tissue in the upper respiratory tract are lower in subjects with sensitization to inhalant antigens. 37 Skin barrier dysfunctions are complex and driven by a combination of genetic, environmental, and immunologic factors that affect gene expression, structural proteins, and lipid profiles. 38 Impaired skin barrier function is caused by changes in the expression of key structural cornified barrier proteins and skin barrier lipids.…”