Significant changes in nonspecific bronchial responsiveness after isolated immediate bronchospecific reactions caused by isocyanates but not after a late reaction caused by plicatic acid

Malo, Jean‐Luc; L’Archevêque, Jocelyne; Cartier, André

doi:10.1016/0091-6749(89)90491-0

Cited by 9 publications

(3 citation statements)

References 25 publications

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“…An increase in histamine or methacholine airway responsiveness typically occurs after late reactions, but it may also occur after immediate asthmatic reactions [185,[197][198][199][200][201]. Airway responsiveness may also increase without significant changes in FEV 1…”

Section: Expression Of the Responsementioning

confidence: 99%

Standardized challenge testing with pharmacological, physical and sensitizing stimuli in adults

Sterk

Fabbri

Quanjer

et al. 1993

European Respiratory Journal

851

556

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Section: Expression Of the Responsementioning

confidence: 99%

Standardized challenge testing with pharmacological, physical and sensitizing stimuli in adults

Sterk

Fabbri

Quanjer

et al. 1993

European Respiratory Journal

851

556

View full text Add to dashboard Cite

“…In this study, one patient developed an isolated early reaction and three were dual responses. In patient Y.H,, airway hyperresponsiveness developed after an isolated early asthmatic response on chromium BPT a& has been reported in some patients with isocyanate-induced asthma [25,26]. Although the mechanism of the development of airway hyperresponsiveness to methacholine in this patient is not clear, this study suggests that negative methacholine challenge test does not necessarily preclude the diagnosis of occupational asthma caused by chromium.…”

Section: Discussionmentioning

confidence: 59%

Occupational asthma caused by chromium

Park

Jung

1994

Clin Experimental Allergy

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We report four cases of occupational asthma caused by chromium salts, three of whom showed dual and one isolated early asthmatic responses on specific chromium bronchoprovocation test (BPT). All of them were ex-smokers. Two showed positive skin-prick tests to 10 mg/ml of Cr2(SO4)3, but negative results on patch testing. The remaining two showed positive results on patch testing with Cr2(SO4)3. Three had airway hyperresponsiveness to methacholine on initial examination. Although initial methacholine airway challenge testing showed a negative result in the remaining patient, airway hyperresponsiveness developed transiently 24 h after an isolated immediate asthmatic reaction induced by chromium. Three patients were reassessed after complete avoidance of chromium. Two subjects showed marked improvement of their symptoms with significant increases of PC20 methacholine. We conclude that chromium induces occupational asthma in exposed workers. Further investigations are needed to clarify the pathogenetic mechanism.

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“…This kind of reaction is often seen with occupational asthma [1,2]. Furthermore, changes in bronchial responsiveness can also occur after isolated immediate reactions [11,12].…”

mentioning

confidence: 99%

Occupational asthma: validity of monitoring of peak expiratory flow rates and non-allergic bronchial responsiveness as compared to specific inhalation challenge

Perrin¹,

Lagier²,

L’Archevêque³

et al. 1992

Eur Respir J

110

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The sensitivity and specificity of monitoring peak expiratory flow rates (PEFR) and bronchial responsiveness to the provocative concentration of histamine or methacholine (PC20) has been determined as compared to specific inhalation challenges in the diagnosis of occupational asthma. A prospective study of 61 subjects referred for occupational asthma to various agents was performed. PEFR was assessed every 2 h during a period away from work for at least 2 weeks. The period at work was 2 weeks, or less if there was increased symptomatology or marked changes in PEFR. At least one PC20 assessment was obtained at work and away from work. Graphs of PEFR and PC20 values were interpreted in blind fashion by three experienced readers. There was complete agreement among the three in 54 out of 61 instances (78%). Twenty five out of 61 subjects (41%) had positive specific inhalation challenges. The best index for comparing results of PEFR with specific inhalation challenges was the visual analysis of PEFR with sensitivity and specificity of 81% and 74%. All of the numerical indices were significantly less satisfactory. We conclude that visual analysis of PEFR is an interesting tool for investigating occupational asthma, although sensitivity and specificity values do not seem satisfactory enough to warrant using it alone.

show abstract

Significant changes in nonspecific bronchial responsiveness after isolated immediate bronchospecific reactions caused by isocyanates but not after a late reaction caused by plicatic acid

Cited by 9 publications

References 25 publications

Standardized challenge testing with pharmacological, physical and sensitizing stimuli in adults

Standardized challenge testing with pharmacological, physical and sensitizing stimuli in adults

Occupational asthma caused by chromium

Occupational asthma: validity of monitoring of peak expiratory flow rates and non-allergic bronchial responsiveness as compared to specific inhalation challenge

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