Significant Association of Polymorphisms in the TCF7L2 Gene with a Higher Risk of Type 2 Diabetes in a Moroccan Population

Elhourch, Sarah; Arrouchi, Housna; Mekkaoui, Nour; Allou, Younes; Ghrifi, Fatima; Allam, Loubna; Elhafidi, N.; Belyamani, Lahcen; Ibrahimi, Azeddine; Elomri, N.; Eljaoudi, Rachid

doi:10.3390/jpm11060461

Cited by 8 publications

(3 citation statements)

References 33 publications

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“…23 In agreement with the current work, the T allele was more frequent in subjects with diabetes (45.3%) than healthy controls (34.5%) and is associated with a high risk of diabetes with an odds ratio of 2.13, (95% CI 1.12-7.31, p =0.005) in a Moroccan population. 24 compared to the C allele with an allelic odds ratio of 2.07 (95% CI 1.39-3.09, p=0.0004, and significantly increase T2DM risk even after adjusting for BMI.…”

Section: Resultsmentioning

confidence: 98%

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Single Nucleotide Polymorphism at rs7903146 of Transcription Factor 7-like 2 gene Among Subjects with Type 2 Diabetes Mellitus in Myanmar

Phu

Thida

Maung

et al. 2023

JAFES

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Objectives. To investigate the association between single nucleotide polymorphism (SNP) at rs7903146 in the transcription factor 7-like 2 (TCF7L2) gene and type 2 diabetes mellitus (T2DM) and to examine the impact of this variant on pancreatic beta-cell function in the Myanmar population.Methodology. A case-control study was undertaken in 100 subjects with T2DM and 113 controls. The SNP rs7903146 was genotyped by the allele-specific polymerase chain reaction method. Plasma glucose and serum insulin levels were determined by enzymatic colorimetric method and ELISA respectively. Beta-cell function was calculated by the HOMA-β formula.Results. The frequencies of carrier genotypes (CT and TT) were higher in subjects with T2DM than in controls. The minor T alleles of rs7903146 were found to statistically increase type 2 diabetes risk than the C allele with an allelic odds ratio of 2.07 (95% CI 1.39-3.09, p=0.0004). The mean HOMA-β level of the group with non-carrier genotype (CC) was significantly higher than that of the groups with carrier genotypes (CT and TT) in subjects with T2DM and controls with a p-value of 0.0003 and less than 0.0001, respectively.Conclusion. SNP at rs7903146 of TCF7L2 gene was found to be associated with T2DM and low β-cell function among Myanmar subjects.

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Section: Resultsmentioning

confidence: 98%

“… 26 In agreement with the current work, the T allele was more frequent in subjects with diabetes (45.3%) than healthy controls (34.5%) and is associated with a high risk of diabetes with an odds ratio of 2.13, (95% CI 1.12-7.31, p =0.005) in a Moroccan population. 27 …”

Section: Discussionmentioning

confidence: 99%

Single Nucleotide Polymorphism at rs7903146 of Transcription Factor 7-like 2 gene Among Subjects with Type 2 Diabetes Mellitus in Myanmar

Phu

Thida

Maung

et al. 2023

JAFES

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“…Besides, the T allele was more frequent in diabetic subjects compared to the control group (45.2%, 34.5% respectively). [13].…”

Section: Tcf7l2 (Transcription Factor 7-like 2) Alleles(rs7903146) (C...mentioning

confidence: 99%

Genomic Study of TCF7L2 Gene Mutation on Insulin Secretion for Type 2 DM Patients: A Review

Darwish

Alrahbi

Almamri

et al. 2022

ARRB

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Aim: This paper aims to establish whether a correlation between TCF7L2 gene mutation on insulin secretion for Type 2 DM Patients. Background: Diabetes type 2 is the most common metabolic disorder worldwide. Beta cell dysfunction reduces insulin secretion and increases the glucose level in the blood and insulin resistance that raises the glucose production in the liver and decreases the glucose uptake to muscle, liver, and adipose tissue causing hyperglycemia (T2DM). TCF7L2 (transcription factor 7–like 2) works as a nuclear Receptor for CTNNB1(B catenin) that mediated the WNT signaling pathway (a group of signal transduction pathways made of proteins that pass signals from outside a cell through cell surface receptors to the inside of the cell) and any variation will cause the development of T2DM. Methods: GenBank in NCBI database was used to extract the DNA sequence and mRNA sequence of the TCF7L2 gene (an accession number of the gene, number of amino acids, exons, and length of nucleotides). FASTA format was also useful to retrieve the nucleotide sequence and get the function of the protein. BLAST was used to compare the protein product of the TCF7L2gene between humans and gorillas, and pygmy chimpanzees (Pan paniscus). Results: The accession number is NC_000010.11, the number of amino acids in the protein product is 602, the number of exons found is 20 and the gene is in chromosome 10. Finally, many organisms have the same gene as dogs, cows, mice, rats, zebrafish, and frogs. Conclusion: There is a strong association between TCF7L2 (transcription factor 7–like 2) alleles (rs7903146) T alleles and T2DM. It was found that there is a high frequency of diabetic type two patients having TCF7L2 (transcription factor 7–like 2) alleles (rs7903146) with a high frequency of the T allele.

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Arterial Stiffness and the Canonical WNT/β-catenin Pathway

Vallée

2022

Curr Hypertens Rep

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Significant Association of Polymorphisms in the TCF7L2 Gene with a Higher Risk of Type 2 Diabetes in a Moroccan Population

Cited by 8 publications

References 33 publications

Single Nucleotide Polymorphism at rs7903146 of Transcription Factor 7-like 2 gene Among Subjects with Type 2 Diabetes Mellitus in Myanmar

Single Nucleotide Polymorphism at rs7903146 of Transcription Factor 7-like 2 gene Among Subjects with Type 2 Diabetes Mellitus in Myanmar

Genomic Study of TCF7L2 Gene Mutation on Insulin Secretion for Type 2 DM Patients: A Review

Arterial Stiffness and the Canonical WNT/β-catenin Pathway

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