Significant association of high-risk human papillomavirus (HPV) but not of p53 polymorphisms with oral squamous cell carcinomas in Malaysia

Abstract

This study indicates that high-risk HPV infection is one of the contributing factors for OSCCs. HPV 16 was the predominant type found in Malaysian patients with OSCC. Further, we did not find any association between p53 codon 72 polymorphism and HPV infection or between the p53 polymorphism and the risk of oral cancer.

Association between p53 Gene Variants and Oral Cancer Susceptibility in Population from Gujarat, West India

“…When comparison was made for all other cancers from India, proline allele was at risk for colorectal cancer and bladder cancer but it was found to be protective in breast cancer and prostate cancer and no association was observed for head and neck cancer (Pandith et al, 2010;Sameer et al, 2010;Suresh et al, 2010;Mittal et al, 2011). Studies from other populations showed conflicting results for the association of Arg72Pro polymorphism with oral cancer risk (Kietthubthew et al, 2003;Kuroda et al, 2007;Saini et al, 2011). Francisco et al (2011) suggested that ethnicity, allelic frequency, histological and anatomical sites may modulate the penetrance of Arg72Pro in cancer susceptibility.…”

HPV-16/18 detection does not affect the prognosis of head and neck squamous cell carcinoma in younger and older patients

“…Some studies suggest that in younger patients, HNSCC arises regardless of the classical risk factors (4)(5)(6)(7)(8)10). HPV infection has been suggested as a possible etiologic factor for such cases (11)(12)(13)(14)(15)(16). HPV was detected in a variety of HNSCCs (11)(12)(13)(14)(15)17) and it was suggested to be associated with lesions of potential malignisation in the head and neck (18,19); however, divergent results are found in the literature regarding the role of HPV presence in HNSCC (20,21).…”

Association Between p53 Arg72Pro Polymorphism and the Risk of Human Papillomavirus-related Head and Neck Squamous Cell Carcinoma: A Meta-analysis

“…For instance, Zhou et al ) investigated HPV-related HNSCC as a subgroup; however, only three studies were included in the previous meta-analysis (Summersgill et al, 2000;Nagpal et al, 2002;Katiyar et al, 2003). Jiang et al (2013) included four relevant studies (Summersgill et al, 2000;Nagpal et al, 2002;Katiyar et al, 2003;Saini et al, 2011), but no subgroup analysis was performed. In contrast to these previous meta-analyses Jiang et al, 2013), the present meta-analysis only focused on HPV-related HNSCC and nine studies were considered.…”

“…Nine studies involving 1071 HNSCC cases were included in the meta-analysis (Summersgi ll et al, 2000;Nagpal et al, 2002;Katiyar et al, 2003;Cortezzi et al, 2004;Scheckenbach et al, 2004;Perrone et al, 2007;Hoffmann et al, 2009;Saini et al, 2011;. Figure 1 shows the screening process.…”

“…Two studies were from the USA [ethnicity was mixed (white, black, and others; or non-Hispanic white and others)] (Summersgill et al, 2000;, two were from India (Nagpal et al, 2002;Katiyar et al, 2003), one was from Malaysia (Saini et al, 2011), two were from Germany (Scheckenbach et al, 2004;Hoffmann et al, 2009), one was from Italy (Perrone et al, 2007), and one was from Brazil (Cortezzi et al, 2004). The baseline characteristics of the patients are shown in Table 1.…”