Significant aspects and correlation between glycemic control and generalized chronic periodontitis in type 2 diabetes mellitus patients

Stoicescu, Manuela; Calniceanu, Horea; Tig, Ioan; Nemeth, Sebastian; Ţenţ, Adriana; Popa, Adina; Brisc, Ciprian; Ignat-Romanul, Ioana

doi:10.3892/etm.2021.10103

Cited by 10 publications

(6 citation statements)

References 29 publications

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“…31 Stoicescu et al divided 182 periodontitis patients into two groups based on their glycemic control levels, it was observed that group with poor glycemic control had higher clinical attachment loss and more sites with pocket depth ≥5 mm. 32 Winning et al discovered that poor glycemic control patients had higher PD, CAL, and BoP values when compared to good glycemic control patients, as did the current study. 33 When Garcia et al analyzed the data from the National Health and Nutrition Examination Survey between 2009 and 2012, it was shown that as glycohemoglobin levels increase, the probability to have periodontitis increases.…”

Section: Discussionsupporting

confidence: 73%

Comparison of 1999 and 2018 Periodontal Disease Classifications in Diabetic and Smoker Groups: A Retrospective Study

BEŞİROĞLU¹,

YÜKSEK²

2023

Turkiye Klinikleri J Dental Sci

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Periodontitis is inflammatory disease that develops due to host response to microbial dental plaque. It can lead to loss of periodontal attachment and result in alveolar bone resorption and tooth loss (TL). The primary etiological agent in formation of periodontitis is microbial dental plaque; however, local/environmental factors also play role in development of this disease. 1,2 Correct classification of diseases and clinical conditions according to their severity, extent and prognosis is useful for clinical decision making and scientific research. Classifications for periodontal diseases have been made over the years according to scientific findings and needs. 3 According to 1999 periodontal disease classification, periodontitis was classified as chronic (CP), aggressive (AgP), necro-

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Section: Discussionsupporting

confidence: 73%

Comparison of 1999 and 2018 Periodontal Disease Classifications in Diabetic and Smoker Groups: A Retrospective Study

BEŞİROĞLU¹,

YÜKSEK²

2023

Turkiye Klinikleri J Dental Sci

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“…У хворих на цукровий діабет практично у 100 % випадків виявляється хронічний генералізований пародонтит різного ступеня важкості. Цукровий діабет впливає на швидке прогресування захворювань тканин пародонта, відзначається більш тяжкий характер захворювання із значним уповільненням регенеративних і репаративних процесів [5][6][7][8].…”

Section: львівський національний медичний університет імені данила га...unclassified

Dynamics of Paraclinical Indices as a Result of Complex Treatment of Generalized Periodontitis in Patients with Type I Diabetes Mellitus with Cardiomyopathy

Shkrebnyuk¹,

Dyryk²,

Vynogradova³

et al. 2022

Ukr. ž. med. bìol. sportu

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The purpose of the study was to trace the dynamics of periodontal indices after comprehensive treatment of generalized periodontitis in patients with type I diabetes mellitus complicated by cardiomyopathy. Materials and methods. Comprehensive treatment and prevention measures were performed in 127 patients with generalized periodontitis on the background of type I diabetes mellitus with cardiomyopathy. The main group, where treatment was carried out with the help of the treatment and prevention scheme developed by us, included 82 people: 25 patients with generalized periodontitis of primary stage – I degree (30.48%); 27 patients with generalized periodontitis of the II degree (32.93%) and 30 – with generalized periodontitis of the III degree (36.59%). The control group, in which the treatment was carried out according to protocol methods, consisted of 45 patients: 14 people with primary stage – generalized periodontitis of the I degree (30.71%), 15 patients with generalized periodontitis of the II degree (33.07%) and 16 patients with generalized periodontitis of the III degree (36.22%). Given the somatic status of the examined patients due to type I diabetes mellitus with cardiomyopathy, clinical visual examination and determination of paraclinical indices were performed 30 days after treatment. The developed algorithm of treatment and prophylactic measures included both local therapy and general appointments. In the control group, the treatment of generalized periodontitis was performed according to conventional methods. Results and discussion. According to the results of the studies, on the 30th day after treatment, in patients of the main group, who were assigned to the developed treatment complex, with generalized periodontitis of the primary stage – I severity, PMA index decreased from 19.00±2.25% before treatment and was 13.17±2.26% after treatment, p >0.05. Periodontal index data in this group of subjects after treatment was 0.42±0.14 points against 0.65±0.12 points before treatment. In patients with generalized periodontitis of the II degree of severity of the main group, on the 30th day after treatment, a decrease in PMA index data was relative to pre-treatment data (28.14±2.70% versus 50.46±2.65%, p <0.01) and periodontal index (1.90±0.30 points versus 2.83±0.44 points, p <0.01). The value of the hygienic index OHI-S in this group of subjects was, after treatment, 2.15±0.71 points against 2.83±0.44 points before treatment, p >0.05. In patients with generalized periodontitis of the II degree of severity of the control group, on the 30th day after treatment, the decrease in PMA indices by 1.2 times and RI – by 1.4 times, p <0.05 with a decrease in the hygienic index by 1.3 times, p >0.05. In patients with generalized periodontitis of the III degree of severity of the main group, on the 30th day after treatment, there was a decrease in the PMA index from 64.42±2.80% before treatment to 35.18±2.70% after treatment, p <0.01. In the studied patients there was a significant decrease in the periodontal index of PI after treatment – up to 2.44±0.10 points against 3.49±0.09 points before treatment, p <0.01. Changes in the hygienic index OHI-S in patients with generalized periodontitis of the III degree of severity were 2.15±0.71 points after treatment against 3.98±1.32 points before treatment, p >0.05. In patients with generalized periodontitis on the background of type I diabetes mellitus of the main group, on average, the PMA index data were by 1.4 times lower, and PI and OHI-S indices were by 1.3 times lower (p1 <0.05, p1 >0.05, respectively) in relation to the average data in patients of the control group. In patients of the main group, the effectiveness of treatment was 42.88% against 18.09% in the control group on the PMA index. Conclusion. As a result of the studies, it can be argued that patients in the main group, where treatment was carried out using our treatment and prevention scheme, significantly improved the condition of periodontal tissues, as evidenced by clinical observations and positive dynamics of paraclinical indices in patients with generalized periodontitis of the control group, where traditional treatment regimens were ineffective

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“…There is growing evidence that a two-way relationship exists between periodontitis and diabetes: diabetes increases the risk of periodontitis and periodontitis is associated with compromised glycemic control [ 8 , 9 , 10 , 11 , 12 ]. Diabetic patients, mostly those displaying poor glycemic control, experience severe forms of gingivitis and are at a high risk of periodontitis onset and progression [ 13 , 14 , 15 ]. The pathogenic process that links these two diseases results from upregulated inflammation arising from each condition exerting mutually adverse effects [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

“…Clinical studies have demonstrated that there is increased colonization by “red complex” microorganisms ( Porphyromonas gingivalis , Tannerella forsythia , Treponema denticola ) in the subgingival plaque of individuals with type 2 diabetes [ 14 ]. Moreover, the increased numbers of black pigmented anaerobes at such sub-gingival sites also correlates with disease severity and the raised levels of glycated proteins not only in serum, but also in gingival crevicular fluid [ 14 , 15 , 28 , 29 , 30 ]. It has been reported that the gingival crevicular fluid from the periodontal lesions of diabetic patients contains both glycated albumin and glycated hemoglobin [ 31 ], and that elevated levels of glycated hemoglobin are associated with an increased inflammatory status and correlates with the severity of periodontitis in diabetic patients [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Glycation of Host Proteins Increases Pathogenic Potential of Porphyromonas gingivalis

Śmiga

Smalley

Ślęzak

et al. 2021

IJMS

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The non-enzymatic addition of glucose (glycation) to circulatory and tissue proteins is a ubiquitous pathophysiological consequence of hyperglycemia in diabetes. Given the high incidence of periodontitis and diabetes and the emerging link between these conditions, it is of crucial importance to define the basic virulence mechanisms employed by periodontopathogens such as Porphyromonas gingivalis in mediating the disease process. The aim of this study was to determine whether glycated proteins are more easily utilized by P. gingivalis to stimulate growth and promote the pathogenic potential of this bacterium. We analyzed the properties of three commonly encountered proteins in the periodontal environment that are known to become glycated and that may serve as either protein substrates or easily accessible heme sources. In vitro glycated proteins were characterized using colorimetric assays, mass spectrometry, far- and near-UV circular dichroism and UV–visible spectroscopic analyses and SDS-PAGE. The interaction of glycated hemoglobin, serum albumin and type one collagen with P. gingivalis cells or HmuY protein was examined using spectroscopic methods, SDS-PAGE and co-culturing P. gingivalis with human keratinocytes. We found that glycation increases the ability of P. gingivalis to acquire heme from hemoglobin, mostly due to heme sequestration by the HmuY hemophore-like protein. We also found an increase in biofilm formation on glycated collagen-coated abiotic surfaces. We conclude that glycation might promote the virulence of P. gingivalis by making heme more available from hemoglobin and facilitating bacterial biofilm formation, thus increasing P. gingivalis pathogenic potential in vivo.

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Significant aspects and correlation between glycemic control and generalized chronic periodontitis in type 2 diabetes mellitus patients

Cited by 10 publications

References 29 publications

Comparison of 1999 and 2018 Periodontal Disease Classifications in Diabetic and Smoker Groups: A Retrospective Study

Comparison of 1999 and 2018 Periodontal Disease Classifications in Diabetic and Smoker Groups: A Retrospective Study

Dynamics of Paraclinical Indices as a Result of Complex Treatment of Generalized Periodontitis in Patients with Type I Diabetes Mellitus with Cardiomyopathy

Glycation of Host Proteins Increases Pathogenic Potential of Porphyromonas gingivalis

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