Significance of Visual Evoked Potentials in the Assessment of Visual Field Defects in Primary Open-Angle Glaucoma: A Review

Kothari, Ruchi; Bokariya, Pradeep; Singh, Sanjeet Singh Avtaar; Singh, Ramji

doi:10.1155/2013/418320

Cited by 9 publications

(8 citation statements)

References 18 publications

(23 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The VEP has been employed to identify and monitor glaucomatous nerve damage and the components of the flash‐VEP are reduced in glaucoma . Our findings from the flash‐VEP recording showed that both amplitude and latency of the main P2 component were affected by I/R injury.…”

Section: Discussionmentioning

confidence: 76%

“…The VEP has been employed to identify and monitor glaucomatous nerve damage 25,26 and the components of the flash-VEP are F I G U R E 6 In vitro co-culture of BM-derived Sca-1 + cells with retina explants decreased retinal cell apoptosis. Retina explants were cocultured with BM-derived Sca-1 + or Sca-1 − cells under normoxia and hypoxia conditions.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Young bone marrow Sca‐1 cells protect aged retina from ischaemia‐reperfusion injury through activation of FGF2

Shao

et al. 2018

J Cellular Molecular Medi

View full text Add to dashboard Cite

Retinal ganglion cell apoptosis and optic nerve degeneration are prevalent in aged patients, which may be related to the decrease in bone marrow (BM) stem cell number/function because of the possible cross‐talk between the two organs. This pathological process is accelerated by retinal ischaemia‐reperfusion (I/R) injury. This study investigated whether young BM stem cells can regenerate and repair the aged retina after acute I/R injury. Young BM stem cell antigen 1 positive (Sca‐1+) or Sca‐1− cells were transplanted into lethally irradiated aged recipient mice to generate Sca‐1+ and Sca‐1− chimaeras, respectively. The animals were housed for 3 months to allow the young Sca‐1 cells to repopulate in the BM of aged mice. Retinal I/R was then induced by elevation of intraocular pressure. Better preservation of visual function was found in Sca‐1+ than Sca‐1− chimaeras 7 days after injury. More Sca‐1+ cells homed to the retina than Sca‐1− cells and more cells differentiated into glial and microglial cells in the Sca‐1+ chimaeras. After injury, Sca‐1+ cells in the retina reduced host cellular apoptosis, which was associated with higher expression of fibroblast growth factor 2 (FGF2) in the Sca‐1+ chimaeras. Young Sca‐1+ cells repopulated the stem cells in the aged retina and diminished cellular apoptosis after acute I/R injury through FGF2 and Akt signalling pathways.

show abstract

Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Young bone marrow Sca‐1 cells protect aged retina from ischaemia‐reperfusion injury through activation of FGF2

Shao

et al. 2018

J Cellular Molecular Medi

View full text Add to dashboard Cite

show abstract

“…On the other hand, they are all subjective tests, which need patients’ input and are easily influenced by patients’ comprehension, emotion and psychological state. Visual evoked potential, as an objective visual functional test, provides a unique tool to assess the visual functional impairment in glaucoma patients [10–12]. Specifically, PVEP has been shown increasing abnormalities as glaucomatous optic nerve damage progressed [13].…”

Section: Introductionmentioning

confidence: 99%

Associations of subjective and objective clinical outcomes of visual functions with quality of life in Chinese glaucoma patients: a cross-sectional study

2019

View full text Add to dashboard Cite

Background The cost of managing a chronic disease like glaucoma is quite large. A convenient and economical monitoring tool like self-reported measures of Quality of Life (QoL) could have the potential to significantly reduce the health economic burden of this disease. However, evidence about whether QoL can effectively reflect both subjective and objective clinical outcomes of visual functions in glaucoma patients is lacking. In this paper, we examined the relationships between both subjective and objective visual functions and QoL in glaucoma patients. Methods This cross-sectional study enrolled 107 patients with a broad range of glaucomatous visual function loss. Subjective visual function loss was assessed using tests of visual acuity (VA), contrast sensitivity (CS) and visual field (VF). Evaluation of objective visual function was performed using pattern visual evoked potentials (PVEP). National Eye Institute Visual Function Questionnaire 25 (NEI VFQ-25) and Glaucoma Quality of Life-15 (GQL-15) were used to measure QoL. Uni- and multivariable linear regression analyses were performed to investigate the associations between all the clinical variables with Rasch-calibrated QoL scores. Results Univariate analysis revealed that worse Rasch-calibrated NEI VFQ and GQL scores were associated with poorer VA and CS in both the better eye (BE) and the worse eye (WE), and with worse VF mean deviation, VF pattern standard deviation and PVEP latency and amplitude in 15 min check size in the WE ( P < 0.05). Multivariable linear regression analysis revealed that, after adjusting for age, gender, duration of glaucoma, glaucoma severity and glaucoma type, Rasch-calibrated NEI VFQ-25 person measure scores were significantly associated with PVEP latency in 15 min check size [ β = − 0.347, 95% CI : (− 0.618, − 0.118), P = 0.001] in the WE; Rasch-calibrated GQL-15 person measure scores were significantly associated with PVEP amplitude in 15 min check size [ β = − 0.338, 95% CI : (− 0.588, − 0.108), P < 0.001] in the WE. Conclusions Self-reported measures of QoL could be supplemental tools for assessing both subjective and objective visual functions in glaucoma patients. Electronic supplementary material The online version of this article (10.1186/s12886-019-1176-0) contains supplementary material, which is available to authorized users.

show abstract

“…Visual evoked potential is an important electrophysiological objective tool which can be used for the evaluation of visual field defects in primary open-angle glaucoma. 3 The severity of visual field defect can lead to delay in the neural conduction from the retina to the visual cortex. The positive correlation between MD, PSD and VEP latencies in cases of glaucoma confirms it.…”

Section: Discussionmentioning

confidence: 99%

“…1 The diagnostic criteria of POAG is a triad of raised IOP, characteristic visual field defect and cupping of optic nerve head with presence of open angles and absence of any secondary cause of raised IOP. 2,3 Visual evoked potential (VEP) is an important diagnostic tool that can be used to study the optic nerve head and visual field changes in cases of POAG. Increased latencies and decreased amplitude of VEP both have been documented in cases of glaucoma.…”

Section: Introductionmentioning

confidence: 99%

Correlation Between VEP Latency, CDR and PSD On Standard Automated Perimetry In Newly Diagnosed POAG Cases

Baisakhiya¹

2018

DJO

View full text Add to dashboard Cite

Significance of Visual Evoked Potentials in the Assessment of Visual Field Defects in Primary Open-Angle Glaucoma: A Review

Cited by 9 publications

References 18 publications

Young bone marrow Sca‐1 cells protect aged retina from ischaemia‐reperfusion injury through activation of FGF2

Young bone marrow Sca‐1 cells protect aged retina from ischaemia‐reperfusion injury through activation of FGF2

Associations of subjective and objective clinical outcomes of visual functions with quality of life in Chinese glaucoma patients: a cross-sectional study

Correlation Between VEP Latency, CDR and PSD On Standard Automated Perimetry In Newly Diagnosed POAG Cases

Contact Info

Product

Resources

About