Significance of viral status on recurrence of hepatitis B‐related hepatocellular carcinoma after curative therapy: A meta‐analysis

Abstract

The present study suggested that HCC patients with high viral load, genotype C and BCP mutation had a significantly higher risk of recurrence. Antiviral therapy has potential beneficial effects after the curative treatment of HCC in terms of tumor recurrence.

Significance of viral status on prognosis of hepatitis B‐related hepatocellular carcinoma after curative resection in East Asia

“…Compared with those with instantaneous high HBV DNA level, patients with persistent high HBV DNA level at resection and follow up had the highest recurrence risk . Meanwhile, in a previous meta‐analysis, our data also proved that high viral load was associated with a significantly higher risk of recurrence after curative therapy of HCC . Theoretically, it is likely that these subjects who have ongoing active HBV replication are more prone to HCC development in remaining liver tissue.…”

“…However, in Wu et al .’s study, the significant relationship between precore mutation, V1753, BCP double mutations and the HCC recurrence was not proved . In our previous meta‐analysis, the results also showed that the presence of 1762T/1764A double mutations was significantly associated with HCC recurrence after curative therapy . Additionally, pre‐S deletion was another hot spot mutation which had been extensively investigated.…”

Influence of antiviral therapy on survival of patients with hepatitis B-associated hepatocellular carcinoma undergoing transarterial chemoembolization

“…As the viral load decreases, the genetic stability in hepatocytes is improved that helps further regeneration. In a metaanalysis, the authors reported the decrease in HCC recurrence with decreasing viral load [20]. In the current study, HBV reactivation was seen in 42 (11.7 %) patients after 6 months of initial TACE.…”

Efficacy of antiviral therapy with nucleotide/nucleoside analogs after curative treatment for patients with hepatitis B virus-related hepatocellular carcinoma: A systematic review and meta-analysis

“…Nevertheless, the meta-analyses of well-designed non-RCTs have been demonstrated as accurate as RCTs [36]. To the best of our knowledge, two previous meta-analyses were conducted to examine the effect of antiviral therapy with NA on patients with HBV-related HCC after curative treatment [37,38]. The current study was performed on the basis of updated data from recent reports focusing on HBV-related HCC after curative treatment [12,27,32,34].…”