Significance of ventricular arrhythmias in idiopathic dilated cardiomyopathy

Meinertz, Thomas; Hofmann, Thomas; Kasper, Wolfgang; Treese, N; Bechtold, H.; Stenen, Ulrich; Pop, T.; Leitner, Enz-Rüdiger von; Andresen, Dietrich; Meyer, Jürgen

doi:10.1016/0002-9149(84)90522-8

Cited by 394 publications

(96 citation statements)

References 19 publications

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“…This relationship is supported by data regarding conditions such as ischemic heart disease, particularly after myocardial infarction (26), as well as dilatative cardiomyopathies (27). If this is so, one-third of our PSS patients (i.e., the 14 subjects with multiform and/or repetitive VPB and concomitant echocardiographic myocardial involvement) would b e at risk of serious cardiac complications.…”

Section: Discussionsupporting

confidence: 70%

Noninvasive evaluation of cardiac dysrhythmias, and their relationship with multisystemic symptoms, in progressive systemic sclerosis patients

Ferri

Bernini

Bongiorni

et al. 1985

Arthritis & Rheumatism

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Fifty‐three patients (34 who had diffuse scleroderma, and 19 who had CREST syndrome [calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasias]) were studied by noninvasive procedures, including resting electrocardiogram (ECG), continuous 24‐hour Holter ECG monitoring, M‐mode echocardiography, and 2‐dimensional echocardiography. Only 22 patients (42%) had abnormalities such as conduction defects, supraventricular or ventricular arrhythmias, or ST‐T changes detected on resting ECG. In contrast, using Holter monitoring, the number of conduction abnormalities seen increased from 10 to 16 patients and transient ST‐T changes increased from 2 to 18 patients. Forty‐eight patients had ventricular arrhythmias, with multiform ventricular premature beats in 21 (40%), pairs of runs of ventricular tachycardia in 15 patients (28%), and 1 or more runs of ventricular tachycardia in 7 (13%). Echocardiography detected asymmetric septal hypertrophy in 10 patients, impaired ventricular function in 9 patients, congestive cardiomyopathy in 2, mitral prolapse in 4, and pericardial effusion in 3 patients. Multiform and/or repetitive ventricular premature beats occurred more frequently in patients with echocardiographic abnormalities, but were also present in patients who had normal findings on echocardiographic examination. Cardiac involvement was not correlated with clinical variants of scleroderma (CREST syndrome or diffuse scleroderma), nor with other signs and symptoms of the disease. Thus, cardiac involvement is found much more frequently than would be expected from clinical symptoms or from results of resting ECG alone; therefore, Holter monitoring and echocardiography should be included in the routine workup of patients who have scleroderma.

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Section: Discussionsupporting

confidence: 70%

Noninvasive evaluation of cardiac dysrhythmias, and their relationship with multisystemic symptoms, in progressive systemic sclerosis patients

Ferri

Bernini

Bongiorni

et al. 1985

Arthritis & Rheumatism

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“…Patients with heart failure have a high prevalence of potentially serious arrhythmias and, consequently, a high incidence of sudden cardiac death. [23][24][25] The presence of ventricular arrhythmias also defines a high-risk patient group with either ischemic or nonischemic cardiomyopathy. [26][27][28][29] This gives special importance to the thermal therapy for heart failure july .…”

Section: Cardiac Arrhythmias and Suddenmentioning

confidence: 99%

Thermal Therapy: A Viable Adjunct in the Treatment of Heart Failure?

Mussivand

Alshaer

Haddad

et al. 2008

Congestive Heart Failure

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The aim of this work was to review and provide a summary of published literature on the clinical impact of thermal therapy (ie, warm water immersion, traditional sauna bathing, and dry infrared sauna) in patients with heart failure. Medline and Embase database literature searches were conducted, and studies that included measurement of heart failure‐related clinical parameters were reviewed. Thermal therapy was found to have a positive impact on key heart failure‐related parameters across multiple studies. Significant improvements were noted across a wide scope of heart failure‐related parameters in the areas of (1) endothelial function, (2) hemodynamics, (3) cardiac geometry, (4) neurohormonal markers, and (5) quality of life. Of special note, thermal therapy also conveyed a strong antiarrhythmic effect in heart failure patients. The clinical evidence highlights repeatable and compelling data showing that thermal therapy may provide an important and viable adjunct in the treatment of heart failure.

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“…(1980) noted, that in view of the presence of nonsustained ventricular tachycardia, the incidence of sudden death was much higher in patients with dilative cardiorrtyopathy than in those with other diseases. Although several previous studies have investigated the relationship between ventricular dysrhythmias and the prognosis of dilative cardiomyopathy (Holmes et ul., 1985;Haung et ul., 1983;Kuhn ef ul., 1982;Meinertz et al, 1984;Olshauscn e/ al., 1984;Unverferth ef a[., 1984), definite conclusions have yet to be established. We prospectively performed 24-h ambulatory electrocardiographic monitoring, twodimensional (2-D) echocardiography, and cardiac catheterization in 33 patients with left ventricular failure who were diagnosed as having dilative cardiomyopathy.…”

Section: Introductionmentioning

confidence: 99%

Prognostic significance of 24‐hour ambulatory electrocardiographic monitoring in patients with dilative cardiomyopathy: A prospective study

Ikegawa

Chino

Hasegawa

et al. 1987

Clinical Cardiology

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Summary:We studied 33 patients with dilative cardomyopathy to evaluate the predicting factors for sudden death occurring within one year. The information on each of the patients included history, physical examinations, two-dimensional echocardiogranis, 24-h ambulatory electrocardiograms. and cardiac catheterization or autopsy. Patients were followed up for one year. Univariate analysis showed niaximurn number of premature ventricular complexes per hour (PVCs/h)(p= .0012), maximum beats per episode of ventricular tachycardia (VTmax) (p = .0012), and left ventricular end-diastolic pressure (p = ,046) to be significant prognostic risk indicators of sudden death within one year. To select the best combination of factors that predict sudden death, multivariate stepwise logistic regression analysis was performed. By this method, only PVCsIh and VTnlax were selected as the best combination. Probability of sudden cardiac death within I year= 1/( 1 +exp[6.65 -1.78 (log PVCs/h)-0.71 (VTm:in))). The equation showed 85.7 % sensitivity and 69.2% specificity at a probability cutoff p i n t of p = . 124, with accuracy of 72.7%. The incidence of sudden death was 80% in patients showing both frequent ( > 100/h) PVCs and presence of VT (VTrliaxz3), and 6 % in patients with neither or both. We concluded that PVCsIh and VTniax arc independent and significant prognostic factors in patients with dilative cardiomyopathy.

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Significance of ventricular arrhythmias in idiopathic dilated cardiomyopathy

Cited by 394 publications

References 19 publications

Noninvasive evaluation of cardiac dysrhythmias, and their relationship with multisystemic symptoms, in progressive systemic sclerosis patients

Noninvasive evaluation of cardiac dysrhythmias, and their relationship with multisystemic symptoms, in progressive systemic sclerosis patients

Thermal Therapy: A Viable Adjunct in the Treatment of Heart Failure?

Prognostic significance of 24‐hour ambulatory electrocardiographic monitoring in patients with dilative cardiomyopathy: A prospective study

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