Significance of Tumor Marker CA15-3 in Metastatic Breast Cancer

Abstract

Secondary spread of cancer to bones is commonest and frequent phenomenon and enhances the need of special care for sufferers. Bone metastases mostly are the first complication of different variety of cancers which increase the need of care and expensive facilities. Blood dissemination is another common route, might be due to the venous drainage from visceral organs directly into the axial bones. CA 15-3 is a mucinous tumor markers derived from MUC1 gene, provides better guide line about the treatment, recurrence and prognosis. Aim: Aim of the study was to signify the role of tumor marker CA15-3 in metastatic breast cancer.

Correlation of cancer antigen 15-3 (CA15-3) serum level and bony metastases in breast cancer patients

“…Also, CA15-3 was more elevated in patients with multiple metastatic site than in patients with a single metastasis (p = 0.001) (20). Contrary to Reference 17, Hoor Fatima et al have shown that not only is serum concentration of tumor marker dependent on bone metastases but is also consistent with bone scan results (In fact, the higher the serum concentration, the greater the number of metastases; multiple metastases were also evident in bone scan) (21). In several studies, different increased amounts of CA15-3 were reported in patients with bony metastases (22)(23)(24)(25).…”