Significance of Thyroid Dysfunction in Human Cardiac Allograft Procurement

Ja, Macoviak; Ir, McDougall; Mf, Bayer; Brown, Marguerite; Tazelaar, Henry D.; Eb, Stinson

doi:10.1097/00007890-198706000-00010

Cited by 45 publications

(8 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some authors report no difference in heart, kidney, or liver function after transplantation from donors with low versus normal blood levels of thyroid hormone. [21][22][23][24][25] Abnormal heart function in the donor and its possible causes are reviewed elsewhere. [26][27][28][29] Altered levels of thyroid hormones are considered as a possible cause Abbreviations: BP, blood pressure; CO, cardiac output; CV, cardiovascular; CVP, central venous pressure; diff, difference; EF, ejection fraction; HCO 3 , bicarbonate; IV, intravenous; LAP, left atrial pressure; MAP, mean arterial pressure; OR, operating room; PA, pulmonary artery; Rx, treatment; temp, temperature; TEE, transesophageal echocardiogram; Tx, transplant(ed); ↓'d -decreased; ↑'d -increased.…”

Section: Changes In Thyroid Physiology After Injury Metabolic Stressmentioning

confidence: 99%

A Review of Thyroid Hormone Administration during Adult Donor Care

Powner

Hernandez

2005

Prog Transpl

View full text Add to dashboard Cite

Serum concentrations of thyroid hormones tetraiodothyronine and triiodothyronine commonly are low after head injury and brain death. Thyroid hormone replacement therapy, however, is a controversial part of donor management. This article reviews publications in which thyroid hormone administration was evaluated in human donors. A classification of the "quality" of study methods used in those publications is presented as part of the data review. No publications support the routine administration of thyroid hormone for all donors. "Rescue" replacement in support of cardiac inotropic function is supported by some studies, but the experimental design of those investigations is not optimal. Thyroid hormone replacement and its dosing should be decided by organ procurement organizations as part of treatment protocols.

show abstract

Section: Changes In Thyroid Physiology After Injury Metabolic Stressmentioning

confidence: 99%

A Review of Thyroid Hormone Administration during Adult Donor Care

Powner

Hernandez

2005

Prog Transpl

View full text Add to dashboard Cite

show abstract

“…Thyroid replacement sparked considerable debate in the transplant community and led to several studies both in favor (3,8,(18)(19)(20)(21)(22) and against (5)(6)(7)(23)(24)(25)(26) its use in brain-dead potential organ donors. Several studies documented lower than normal levels of T 3 in brain-dead patients with no correlation with their hemodynamic status (17,23,27).…”

Section: Discussionmentioning

confidence: 99%

“…Several studies documented lower than normal levels of T 3 in brain-dead patients with no correlation with their hemodynamic status (17,23,27). Other studies even showed a trend towards worse outcome with T 4 use (5)(6)(7). Several studies showed a benefit only in hemodynamically unstable donors (28,29).…”

Section: Discussionmentioning

confidence: 99%

“…The ultimate result would be an increase in the number organs available for transplantation. However, hormone therapy with T 4 remains controversial (5–7), and its use nationally is sporadic at best. In this study, we evaluate whether the addition of T 4 has any effect on the number of organs available for transplantation among brain‐dead organ donors who are all managed by an aggressive protocol.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Using thyroid hormone in brain‐dead donors to maximize the number of organs available for transplantation

Salim

Martin

Brown

et al. 2007

Clinical Transplantation

View full text Add to dashboard Cite

The aggressive management of brain-dead (cadaveric) organ donors has been shown to increase organs available for transplantation. Some centers use hormone therapy with thyroid hormone (T(4)) in selected donors. The purpose of this study is to evaluate the effects of T(4) on organs available for transplantation. A policy of aggressive donor management was adopted at our trauma center in 1998. T(4) therapy is reserved for the hemodynamically unstable donors who require significant vasopressor support. The records of patients who successfully donated organs between January 2001 and December 2005 were reviewed. Organ donor demographics and whether T(4) was used was examined for each donor. T(4) was used in 96 of 123 donors (78%). Compared with donors who did not receive T(4), those that did were similar in age (32 +/- 14 vs. 38 +/- 21, p = 0.148), had more organs donated (3.9 +/- 1.7 vs. 3.2 +/- 1.7, p = 0.048), and had no differences in brain-death related complications. Despite the severe hemodynamic instability in the T(4) group, the number of organs harvested from this group was significantly more than in patients who did not receive T(4). The use of T(4) in this group may result in the increased salvage of transplantable organs.

show abstract

“…However, other studies in the literature, although they do document hormonal changes in the brain-dead animals or the donors, could not find any benefit in hormonal therapy. 7,8 This topic remains very controversial.…”

Section: Haemodynamic and Metabolic Effects Of Brain Death On The Donmentioning

confidence: 99%

Transplantation of the heart: An overview of 40 years' clinical and research experience at Groote Schuur Hospital and the University of Cape Town: Part II. Laboratory research experience.

Hassoulas

2012

S Afr Med J

View full text Add to dashboard Cite

Significance of Thyroid Dysfunction in Human Cardiac Allograft Procurement

Cited by 45 publications

References 0 publications

A Review of Thyroid Hormone Administration during Adult Donor Care

A Review of Thyroid Hormone Administration during Adult Donor Care

Using thyroid hormone in brain‐dead donors to maximize the number of organs available for transplantation

Transplantation of the heart: An overview of 40 years' clinical and research experience at Groote Schuur Hospital and the University of Cape Town: Part II. Laboratory research experience.

Contact Info

Product

Resources

About