“…Information is also supplied by a few series of patients with a selected obstetrical problem such as Rh immunization, anemia, drug administration, etc., but the validity of conclusions cannot be extended to other classes of patients. Fortunately, a few investigators, studied, either retrospectively [41,75] or even prospectively [43, 64,67], the etiology, the clinical significance and the outcome of a greater number of pregnancies in which SHR was noted.…”