Significance of the prime factors regulating arsenic toxicity and associated health risk: a hypothesis-based investigation in a critically exposed population of West Bengal, India

Das, Antara; Joardar, Madhurima; Chowdhury, Nirmalya; Mridha, Deepanjan; De, Ayan; Majumder, Sharmistha; Das, Jagyashila; Majumdar, Kunal Kanti; Roychowdhury, Tarit

doi:10.1007/s10653-022-01422-6

Cited by 5 publications

(4 citation statements)

References 84 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gender and age has already been proved to behave as major factors in uencing As metabolism in As exposed Bangladeshi population with an urinary As concentration in the range of 0.5-1994 µg/L; and a median value of 77 µg/L. Recently Das et. al.…”

Section: Discussionmentioning

confidence: 99%

Stool as a novel biomarker for arsenic exposure through diet: a case-control study in a West Bengal population

Ghosh,

Chakraborty,

Bhowmick

et al. 2024

Preprint

Self Cite

View full text Add to dashboard Cite

Geogenic groundwater arsenic (As) contamination is a persistent health threat in the district of Nadia, West Bengal India. Despite provision of safe piped water, local populations in these areas are still exposed to As through diet as the cultivation is majorly dependent on As contaminated shallow groundwater causing significant As accumulation in agricultural foodstuffs. Although urine is an established biomarker for As exposure through drinking water yet, it does not reflect the actual exposure through diet. Hence, stool-As concentration of exposed population should be evaluated to assess the true exposure through diet. The present case-control study evaluates As concentration in stool samples of exposed (n = 24) and unexposed (n = 36) populations. Average stool-As concentration found was 234 ± 207 µg/kg in exposed population while only 66 ± 22 µg/kg in control samples; comparable to those of urine samples of case and control; respectively. Positive Pearson correlation and a significant difference of variance through ANOVA (p = 0.01; Fcrit= 1.65) among stool-As, urine-As, groundwater-As, age and BMI found for case samples indicate that stool also presents comparable and measurable As concentrations upon exposure. Mann-Whitney U test confirms that random values of stool-As in case samples varied significantly (p < 0.001) than those of control samples. Besides, multi-metal analysis of stool digest indicated that stool-As correlated negatively with most of the metals in case and positively with control samples. These observations along with ease of collection and detection due to higher concentration in the matrix, suggest that stool may act as a decisive biomarker of As exposure through diet. To the best of our knowledge, this is a pioneering study to establish stool as a reliable and significant biomarker for assessing As exposure as limited investigations exist focused on human faecal samples on long term naturally exposed adult human population.

show abstract

Section: Discussionmentioning

confidence: 99%

Stool as a novel biomarker for arsenic exposure through diet: a case-control study in a West Bengal population

Ghosh,

Chakraborty,

Bhowmick

et al. 2024

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…The cancer risk (CR) was calculated by multiplying the ADD with the cancer slope factor (CSF) [ 34 ]. CR = ADD × CSF where the CSF of arsenic is 1.5 (mg kg (BW) −1 day −1 ) −1 [ 36 ].…”

Section: Methodsmentioning

confidence: 99%

“…On average, 73% of the As present in rice was assumed to be inorganic [33]. The hazard quotient for children was calculated by assuming the daily intake and body weight as 0.20 kg day −1 [34] and 30 kg [35], respectively. The cancer risk (CR) was calculated by multiplying the ADD with the cancer slope factor (CSF) [34].…”

Section: Hq = Add/rfdmentioning

confidence: 99%

See 1 more Smart Citation

Co-Application of Silicate and Low-Arsenic-Accumulating Rice Cultivars Efficiently Reduces Human Exposure to Arsenic—A Case Study from West Bengal, India

Roy

Datta

Barman

et al. 2023

Toxics

View full text Add to dashboard Cite

We investigated the effect of practically realizable doses of silicate on arsenic (As) uptake by differential-As-accumulating rice cultivars grown on geogenically As-polluted soil. The possible health risk from the dietary ingestion of As through rice was also assessed. In addition, a solution culture experiment was conducted to examine the role of root-secreted weak acids in differential As acquisition by rice cultivars. When grown without silicate, Badshabhog accumulated a much smaller amount of As in grain (0.11 mg kg−1) when compared to the other three varieties. Satabdi, IR-36, and Khitish accumulated As in grain beyond the permissible limit (0.2 mg kg−1) for human consumption. The application of silicate effectively reduced the As content in the grain, husk, and straw of all of the cultivars. The grain As content fell to 17.2 and 27.6% with the addition of sodium metasilicate at the rates of 250 and 500 mg kg−1, respectively. In the case of Khitish, the grain As content was brought down within permissible limits by the applied silicate (500 mg kg−1). The integrated use of low-As-accumulating cultivars and silicate has great potential to reduce the public health risks associated with As. A positive correlation between root-secreted total weak acid and grain As content could explain the different rice cultivars’ differential As acquisition capacity.

show abstract

Severe Disease Burden and the Mitigation Strategy in the Arsenic-Exposed Population of Kaliprasad Village in Bhagalpur District of Bihar, India

Kumar,

Ali

et al. 2023

Biol Trace Elem Res

View full text Add to dashboard Cite

Significance of the prime factors regulating arsenic toxicity and associated health risk: a hypothesis-based investigation in a critically exposed population of West Bengal, India

Cited by 5 publications

References 84 publications

Stool as a novel biomarker for arsenic exposure through diet: a case-control study in a West Bengal population

Stool as a novel biomarker for arsenic exposure through diet: a case-control study in a West Bengal population

Co-Application of Silicate and Low-Arsenic-Accumulating Rice Cultivars Efficiently Reduces Human Exposure to Arsenic—A Case Study from West Bengal, India

Severe Disease Burden and the Mitigation Strategy in the Arsenic-Exposed Population of Kaliprasad Village in Bhagalpur District of Bihar, India

Contact Info

Product

Resources

About