Significance of the pleura in the breathing mechanism

Bodrova, T. N.; Korzilov, A. I.; Tetenev, F. F.

doi:10.1007/bf00846344

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“…The results of lneasurelnent of traditional parameters of respiratory mechanics (work of breathing, its fractions, and lung compliance) were published previously [1]. The minute respiratoq~ volume was tile same in all experimental series ( Table 1).…”

Section: Resultsmentioning

confidence: 99%

Does the system of pleural layers determine paradoxical phenomena in respiratory mechanics?

Tetenev

Bodrova

1997

Bull Exp Biol Med

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Spirogram, transpuhnonary pressure, intraesophageal, intrapleural pressure, and pressnre in a closed bronchus were recorded in 16 healthy rabbits under thiopental anesthesia (first series). Dead rabbits were placed in a chamber, where respiratory movements were simulated by changing pressure, and all the parameters were recorded (second series). The lungs were then isolated and placed in the Donders bell (tlfird series). Deformation of the plateau in transpulmonary pressure during a 0.5-sec interruption of air flow was obse~-ved only in the first series of experiments. The amplitude of pressure in a closed bronchus exceeded intrapleural pressure only in the first series. It is concluded that pleura does not contribute to the paradoxical mechanics of respiration. Key Words: respiration; pleural layer; intrapleural pressureDeformation of a plateau of transpuhnonary pressure (TPP) upon interruption of air flow and the higher amplitude of respiratory fluctuations of pressure in a bronchus than the amplitude of intrapleural pressure are a fundamental paradoxical phenomena contradicting the naodern concepts on the respiratory mechanics [4]. An attempt was made to explain this paradox with the help of the theory of alveolar interdependency [5]. This theory admits the prevalence of negative pressure in alveoli over intrapleuraI pressure due to transmission of the respiratory muscle force to the lung surface via the system of pleural layers.Our objective was to check up the hypothesis that the paradoxical phenomena in the mechanics of respiration are caused by the function of the system of pleural layeJs. The most obvious paradoxes have been chosen: the deformation of TPP plateau upon intemaption of air flow with a valve and the prevalence of amplitude of pressure in a closed bronchus over the amplitude of intrapleural pressure.

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Section: Resultsmentioning

confidence: 99%