Significance of the juxtaoral organ (of Chievitz)

Pantanowitz, Liron; Balogh, Károly

doi:10.1002/hed.10209

Cited by 41 publications

(25 citation statements)

References 29 publications

(28 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The inner layer called stratum fibrosum internum consists of dense collagen fibers that are separated from the epithelial islands by a distinct basal lamina[1011]The middle layer, stratum nervosum, is characterized by loose connective tissue stroma, populated with myelinated and nonmyelinated fibers[1012]The outer layer, the stratum fibrosum externum, connects to the muscle fascia of the buccotemporalis. The basement membrane around these epithelial islands demonstrates PAS positivity.…”

Section: Histopathological Aspect Of This Organmentioning

confidence: 99%

See 1 more Smart Citation

Juxtaoral organ of Chievitz: An innocuous organ to be known

Bommanavar¹,

Hema

Baad³

2017

J Oral Maxillofac Pathol

View full text Add to dashboard Cite

The Juxtaoral Organ of Chievitz is a normal anatomical structure located within the soft tissue in the buccotemporal fascia on the medial surface of the ascending ramus. This enigmatic vestigial structure is considered to be of neuroepithelial origin with no known function. As a matter of fact, JOOC is one of the most treacherous pitfalls in surgical pathology with respect to lesions in the head and neck area. Hence the basic aim of this short communication is to reveal the importance about this organ and enlighten the oral pathologist about this histopathological structure, thus preventing extensive and unnecessary investigations.

show abstract

Section: Histopathological Aspect Of This Organmentioning

confidence: 99%

“…The inner layer called stratum fibrosum internum consists of dense collagen fibers that are separated from the epithelial islands by a distinct basal lamina[1011]…”

Section: Histopathological Aspect Of This Organmentioning

confidence: 99%

Juxtaoral organ of Chievitz: An innocuous organ to be known

Bommanavar¹,

Hema

Baad³

2017

J Oral Maxillofac Pathol

View full text Add to dashboard Cite

show abstract

“…Some clinical aspects of the JOO have also been described (D'Andrea et al 1999). The juxta-oral organ may present as an intraoral mass and even the normal JOO may be misinterpreted to be a pathological tumor or its invasion (Leibl et al 1976;Pantanowitz & Balogh, 2003;Ide et al 2003a). In spite of over 100 years of studies, little is known about the function of the JOO.…”

Section: Introductionmentioning

confidence: 99%

Organogenesis of the juxta‐oral organ in mice

Ito

Nakashima²,

Yoshioka

et al. 2009

Journal of Anatomy

View full text Add to dashboard Cite

The juxta-oral organ is a bilateral organ in the mammalian bucca. It consists of epithelial cords with surrounding mesenchyme. It develops from embryonic oral epithelium, but its macroscopic morphology in mice is less studied and seems to be very different from that of humans. The juxta-oral organ in mice extends more widely from the subcutaneous tissue of the mandible near the lateral fascia of the masseter to the submucosa of the soft palate. In this paper, we report that the mutant mouse allele Bmp7 lacZ presented intense lacZ expression in the epithelial component of the juxta-oral organ in its homo-and heterozygous states. The main aims of this study were to show that this mutant mouse allele is suitable for observing macroscopic structure of the juxta-oral organ and to describe the development of this organ during embryonic and postnatal stages. Whole-mount β-gal staining of this strain of mouse showed that the juxta-oral organ in mice appeared at E12.0 from oral epithelium and lost connection with it before E12.5. Then, the juxta-oral organ extended anteriorly to the lateral fascia of the masseter and posteriorly to the submucosal layer of the soft palate via the orbit. The mature juxta-oral organ had no connection to other epithelia such as those of the bucca and parotid duct. It persisted until adulthood and there seemed to be no tendency to regress. Transmission electron microscopy showed that each part of the juxta-oral organ was an epithelial cord surrounded by a basement membrane and mesenchymal tissue.

show abstract

“…In humans, the possibility of a receptor function of the JOO has been raised (D'Andrea et al, 1999;Pantanowitz and Balogh, 2003;M erida-Velasco et al, 2005). Recently, Ito et al (2009), studying mice, considered the JOO to be a sensory receptor.…”

Section: Juxta-oral Organ In Rat Embryomentioning

confidence: 99%

Development of the Juxta‐Oral Organ in Rat Embryo

Velasco

2012

The Anatomical Record

View full text Add to dashboard Cite

The aim of this work is to clarify the development and morphology of the juxta-oral organ (JOO) in rat embryos from Day (E)14 to 19. Furthermore, in the region of the JOO, an analysis was made of the expression of the monoclonal antibody HNK-1, which recognizes cranial neural-crest cells. In this study, we report that JOO develops from an epithelial condensation at the end of the transverse groove of the primitive mouth at E14. During E15, it invaginates and is disconnected from the oral epithelium. At E16, the JOO forms an solid epithelial cord with three parts (anterior, middle, and posterior) and is related to the masseter, temporal, medial pterygoid, and tensor veli palatini muscles. During E17-19, no significant changes were detected in their position. Both the mesenchyme caudal to the anlage of the JOO at E14, as well as the mesenchyme that surrounds the bud of the JOO at E15, expressed positivity for HNK-1. Our results suggest that the mesenchyme surrounding the JOO at E15 could emit some inductive signal for the JOO to reach its position at E16. This work shows for the first time that the cranial neural-crest-derived mesenchyme participates in the development of the JOO. Anat Rec,

show abstract

Significance of the juxtaoral organ (of Chievitz)

Abstract: Awareness of this normal anatomic structure is important, because the finding of epithelial islands intimately admixed with nerves could be misinterpreted as perineural invasion by carcinoma.

Cited by 41 publications

References 29 publications

Juxtaoral organ of Chievitz: An innocuous organ to be known

Juxtaoral organ of Chievitz: An innocuous organ to be known

Organogenesis of the juxta‐oral organ in mice

Development of the Juxta‐Oral Organ in Rat Embryo

Contact Info

Product

Resources

About