Significance of the expression of integrin β1, VEGF and MVD in hypopharyngeal squamous cell carcinoma

Hong, Yang; Gan, Wenchang; Xu, Zhengquan

doi:10.4238/2014.august.25.9

Cited by 10 publications

(14 citation statements)

References 21 publications

(21 reference statements)

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“…Similar to the controversy concerning metastasis, the associations between β1 integrin and the clinical features of patients are unclear. In certain types of cancer, β1 integrin is associated with poor prognosis or metastasis, including in prostatic cancer (15,24), melanoma (25), gastric carcinoma (26) and hypopharyngeal squamous cell carcinoma (27). However, in other types of cancer, including breast cancer, studies have reported different or contradictory conclusions (28)(29)(30).…”

Section: Metastasismentioning

confidence: 97%

β1 and β3 integrins in breast, prostate and pancreatic cancer: A novel implication (Review)

et al. 2018

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Abstract.Integrins are transmembrane glycoproteins that consist of an α and a β subunit. Specific integrin heterodimers preferentially bind to distinct extracellular matrix (ECM) proteins to affect the characteristics of cells or the components of the ECM. Among the different integrins, β1 and β3 integrins serve essential roles in the progression of different cancer-associated processes, including the initiation, proliferation, survival, migration and invasion. Furthermore, previous studies have revealed a ratio between these two integrins in cancer cells, which also demonstrated that the functions of these two integrins are paradoxical. This indicated that the proliferation and metastasis of cancer cells are not always parallel and may be considered independently maintained. Additionally, the present review may assist in understanding certain aspects of cancer, and in making clinical decisions in a novel and more comprehensive manner. IntroductionIntegrins are transmembrane glycoproteins that consist of an α subunit and a β subunit. A total of eight different β subunits may dimerize, in limited combinations, with 18α subunits to form ≥24 distinct integrins (1,2). Specific integrin heterodimers preferentially bind to distinct extracellular matrix (ECM) proteins. Integrins may bind the ligands in ECM directly, including fibronectin and laminin, to affect the characteristics of cells or the components of ECM. Regarding cancer cells, integrins serve roles in numerous aspects, including proliferation, survival, migration and invasion (1).Integrins primarily affect cells in two ways, the first is through binding with proteins directly, including talin, vinculin and filamin, which may regulate the actin cytoskeleton of cells (3). The other is by phosphorylating the relative kinases, including focal adhesion kinases (FAKs), proto-oncogene tyrosine-protein kinase (Src)-family kinases (SFKs) and integrin-linked kinase (ILK), to activate or cooperate with the other cell signaling pathways (1,4). Additionally, integrin clustering on the cell surface and trafficking from the endosomes may affect the ligand affinity and quantity of the protein on cell surface (5-7).Among the different integrins, β1 and β3 integrins serve essential roles in the progression of different types of cancer (1,2). Furthermore, previous studies investigating the association between these two integrins have demonstrated many different perspectives (8-11), together providing a novel and more comprehensive understanding of cancer. Functions of β1 integrin in cancerIn tumors, the β1 subunit of integrin may combine with different α subunits, including α4, α5 and α2, to affect the characteristics of cancer cells, and the progression of tumors (1). The primary function of β1 integrin is to form focal adhesion between cancer cells and ECM. This adhesion is the basis for the survival of cancer cells and is also associated with their migratory and metastatic capabilities (2). There are series of proteins in the cytoplasm, including talin, kindlin and ILK, ...

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Section: Metastasismentioning

confidence: 97%

β1 and β3 integrins in breast, prostate and pancreatic cancer: A novel implication (Review)

et al. 2018

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“…These facts suggest that targeting integrins overexpressed in cancer cells is a feasible strategy for use in cancer nanomedicine. Fibronectin Increases tumor progression [38] Increases cancer invasion [39] Mediates resistance to radiotherapy [36] Head and neck cancer [40,41] Vitronectin Non-small cell lung cancer [42] Fibrinogen Breast cancer [43] Osteopontin Prostate cancer [44] Ovarian cancer [45] Melanoma [46] ανβ3…”

Section: Integrins In Cancer Nanomedicinementioning

confidence: 99%

Targeting Integrins in Cancer Nanomedicine: Applications in Cancer Diagnosis and Therapy

Opadele

Onodera

et al. 2019

Cancers

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Due to advancements in nanotechnology, the application of nanosized materials (nanomaterials) in cancer diagnostics and therapeutics has become a leading area in cancer research. The decoration of nanomaterial surfaces with biological ligands is a major strategy for directing the actions of nanomaterials specifically to cancer cells. These ligands can bind to specific receptors on the cell surface and enable nanomaterials to actively target cancer cells. Integrins are one of the cell surface receptors that regulate the communication between cells and their microenvironment. Several integrins are overexpressed in many types of cancer cells and the tumor microvasculature and function in the mediation of various cellular events. Therefore, the surface modification of nanomaterials with integrin-specific ligands not only increases their binding affinity to cancer cells but also enhances the cellular uptake of nanomaterials through the intracellular trafficking of integrins. Moreover, the integrin-specific ligands themselves interfere with cancer migration and invasion by interacting with integrins, and this finding provides a novel direction for new treatment approaches in cancer nanomedicine. This article reviews the integrin-specific ligands that have been used in cancer nanomedicine and provides an overview of the recent progress in cancer diagnostics and therapeutic strategies involving the use of integrin-targeted nanomaterials.

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“…Множество проведенных исследований по изучению зако-номерностей роста и прогрессии опухолей кожи показа-ли, что чем выше содержание интегринов в опухоли, тем выше скорость ее инвазии и более выраженный ангиогенез [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. Суть этих исследований заключалась в сравнении количества интегринов на разных клонах одной и той же опухоли, с определением скорости роста, инвазии и мета-стазирования каждого из клонов с последующим сравне-нием их между собой.…”

Section: влияние интегринов на прогрессию опухолей кожиunclassified

“…Суть этих исследований заключалась в сравнении количества интегринов на разных клонах одной и той же опухоли, с определением скорости роста, инвазии и мета-стазирования каждого из клонов с последующим сравне-нием их между собой. Результаты всех исследований были схожими: клоны, имевшие самый быстрый и злокаче-ственный рост, показывали наибольшую экспрессию ин-тегринов по сравнению с менее агрессивными вариантами тех же опухолей [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20].…”

Section: влияние интегринов на прогрессию опухолей кожиunclassified

“…Экспрессия интегрина 1 в клетках ПКР была на 78% выше, чем на клетках здорового эпителия гортани, выше оно было и в метастазах в регионарных лимфатических узлах. Причем по мере прогрессии ПКР наблюдалось уве-личение 1 и MVD от ранних стадий опухолевого процесса к поздним [18,19].…”

Section: плоскоклеточный рак кожиunclassified

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The Role Integrins in Invasii and Metastatic Skin of Malignant Tumors

Titov¹,

Ротин²,

Казаков³

et al. 2016

Zlokač. opuholi

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Роль интегринов в инвазии и метастазировании злокачественных опухолей кожиThe role integrins in invasii and metastatic skin of malignant tumors www.malignanttumours.org • № 1 -2016 г. (17) • MALIGNANT TUMOURS РезюмеЗлокачественные опухоли кожи занимают лидирующее место в онкологической заболеваемости во всем мире. На сегодняшний день, благодаря развитию молекулярной биологии и генетики, становится понятным, что данные опухоли гетерогенны, имеют разные биологические характеристики, что влияет на прогноз заболевания и выбор тактики лечения. К таким изменениям относятся рецепторы интегринов, различная экспрессия которых может влиять на процессы инвазии и метастазирования. Предлагаем обзор современного понимания влияния интергинов на прогрессию опухолей кожи и разработки новых подходов к противоопухолевой терапии. AbstractMalignant tumors of skin take the leading place in neoplastic incidence worldwide. Currently, concerning the development of molecular biology and genetics, it becomes clear that these tumors are heterogenic and have different biological characteristics that of prognostic and predictive significance. Various degree of integrin receptors expression, which can influence processes of an invasion and metastasis, belongs to such changes. We review the problem of modern understanding of the integrin's influence on skin tumor progression and development of new approaches for antineoplastic therapy application.

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Significance of the expression of integrin β1, VEGF and MVD in hypopharyngeal squamous cell carcinoma

Cited by 10 publications

References 21 publications

β1 and β3 integrins in breast, prostate and pancreatic cancer: A novel implication (Review)

β1 and β3 integrins in breast, prostate and pancreatic cancer: A novel implication (Review)

Targeting Integrins in Cancer Nanomedicine: Applications in Cancer Diagnosis and Therapy

The Role Integrins in Invasii and Metastatic Skin of Malignant Tumors

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