Significance of the duration of nephropathy for achieving clinical remission in patients with IgA nephropathy treated by tonsillectomy and steroid pulse therapy

Ieiri, Norio; Hasegawa, Osamu; Sato, Toshinobu; Taguma, Yoshio

doi:10.1007/s10157-011-0530-1

Cited by 34 publications

(23 citation statements)

References 37 publications

(66 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Because of IgA production in tonsillar tissue and the frequent association of symptoms with mucosal infection, in some countries, including China and Japan, tonsillectomy had been reported as an effective treatments to ameliorate clinical symptom in IgAN patients [15,16] Treatment using a combination of tonsillectomy and steroid pulse (TSP) therapy for patients with IgA nephropathy was reported as an effective method in patients to obtain clinical remission (CR) [17,18]. A new long-term study in Japan showed that tonsillectomy was associated with a commendable renal outcome of clinical remission for IgAN patients and delayed renal deterioration even in non-steroid-treated patients [19].…”

Section: Discussionmentioning

confidence: 99%

Capsaicin induces high expression of BAFF and aberrantly glycosylated IgA1 of tonsillar mononuclear cells in IgA nephropathy patients

Shao¹,

Peng²,

He³

et al. 2014

Human Immunology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Capsaicin induces high expression of BAFF and aberrantly glycosylated IgA1 of tonsillar mononuclear cells in IgA nephropathy patients

Shao¹,

Peng²,

He³

et al. 2014

Human Immunology

View full text Add to dashboard Cite

“…Recently, Ieiri et al [6] emphasized that a shorter duration from diagnosis until TSP is associated with a high likelihood of CR in IgA nephropathy patients treated with TSP. In our previous study, the comparison between patients who reached CR and those who did not reach CR revealed significant differences in the number of years from diagnosis until TSP ( P = 0.02), daily proteinuria ( P < 0.0001), serum creatinine ( P = 0.006), and pathological grade ( P = 0.0006).…”

Section: Discussionmentioning

confidence: 99%

Estimated glomerular filtration rate and daily amount of urinary protein predict the clinical remission rate of tonsillectomy plus steroid pulse therapy for IgA nephropathy

2013

View full text Add to dashboard Cite

BackgroundThis retrospective study was designed to estimate the clinical remission (CR) rate of tonsillectomy plus steroid pulse (TSP) therapy in patients with IgA nephropathy.MethodsBased on 292 of 302 patients with IgA nephropathy treated at 11 Japanese hospitals, we constructed heat maps of the CR rate at 1 year after TSP with the estimated glomerular filtration rate (eGFR), grade of hematuria, pathological grade, number of years from diagnosis until TSP, and age at diagnosis on the vertical axis and the daily amount of urinary protein (urinary protein) on the horizontal axis. We compared subgroups usinge Student’s t test, the chi-square test with Yates correction, or Fisher’s exact probability test.ResultsThe first heat map of eGFR and urinary protein showed that the CR rate was 71 % (CR vs. non-CR, 96 vs. 40) in patients with eGFR greater than 30 ml/min/1.73 m2 and 0.3–1.09 g/day of urinary protein. However, the CR rate in patients with more than 1.50 g/day of urinary protein was approximately 30 %. The second heat map of grade of hematuria and urinary protein revealed that the CR rate is 72 % (CR vs. non-CR, 93 vs. 37) in patients with more than 1+ hematuria and 0.3–1.09 g/day of urinary protein; however, it was 28.6 % in patients with no hematuria. The third heat map of pathological grade and urinary protein demonstrated that the highest CR rate was 83 % (CR vs. non-CR, 52 vs. 11) in patients with pathological grade I or II disease and less than 1.09 g/day of urinary protein, as opposed to 22 % (CR vs. non-CR, 9 vs. 32) in patients with pathological grade III or IV disease and more than 2.0 g/day of urinary protein. The fourth heat map of the number of years from diagnosis until TSP and urinary protein revealed that the former did not influence the CR rate in patients with less than 1.09 g/day of urinary protein. However, in patients with more than 1.10 g/day of urinary protein, the CR rate of the subgroup with less than 6 years was 43 % (CR vs. non-CR; 23 vs. 54) compared to 23 % (CR vs. non-CR, 11 vs. 48; P = 0.01) in the subgroup with more than 6 years. The fifth heat map of age at diagnosis and urinary protein showed that the CR rate is approximately 72 % (CR vs. non-CR, 73 vs. 28) in patients older than 19 years at diagnosis with 0.3–1.09 g/day of urinary protein.ConclusionsThe daily amount of urinary protein is an important predictor of the CR rate after TSP in IgA nephropathy patients. Heat maps are useful tools for predicting the CR rate associated with TSP.

show abstract

“…To the Editor, Suzuki et al [1] showed in their original article that the number of years from diagnosis until tonsillectomy and steroid pulse (TSP) therapy did not influence the clinical remission (CR) rate in IgA nephropathy (IgAN) patients treated with TSP, and they concluded that their results were not in accordance with our previous study [2] which demonstrated that a shorter duration from diagnosis until TSP was associated with a high likelihood of CR in IgAN patients treated with TSP.…”

mentioning

confidence: 86%

“…Our previous study [2] demonstrated that the duration of nephropathy (DN), not the number of years from diagnosis until TSP therapy, was the most veridical predictor of CR as compared with other clinical features such as estimated glomerular filtration rate, age or degree of proteinuria at time of initiation of treatment in IgAN patients treated by TSP therapy. In our study the DN was defined as the period from the first manifestation of hematuria to the initiation of TSP therapy.…”

mentioning

confidence: 99%

Importance of the duration of nephropathy prior to tonsillectomy and steroid pulse therapy in IgA nephropathy patients

Ieiri

Hasegawa

2014

Clin Exp Nephrol

Self Cite

View full text Add to dashboard Cite

Significance of the duration of nephropathy for achieving clinical remission in patients with IgA nephropathy treated by tonsillectomy and steroid pulse therapy

Abstract: Shorter DN is associated with higher likelihood of clinical remission in IgAN patients treated by TSP therapy.

Cited by 34 publications

References 37 publications

Capsaicin induces high expression of BAFF and aberrantly glycosylated IgA1 of tonsillar mononuclear cells in IgA nephropathy patients

Capsaicin induces high expression of BAFF and aberrantly glycosylated IgA1 of tonsillar mononuclear cells in IgA nephropathy patients

Estimated glomerular filtration rate and daily amount of urinary protein predict the clinical remission rate of tonsillectomy plus steroid pulse therapy for IgA nephropathy

Importance of the duration of nephropathy prior to tonsillectomy and steroid pulse therapy in IgA nephropathy patients

Contact Info

Product

Resources

About