Significance of the cribriform pattern in prostatic adenocarcinomas

Sarbay, Billur Cosan; Kır, Gözde; Topal, Cumhur Selçuk; Gümüş, Eyüp

doi:10.1016/j.prp.2014.03.003

Cited by 45 publications

(28 citation statements)

References 11 publications

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“…In addition to the percentage of Gleason pattern 4, some recent studies have indicated that the different subtypes of Gleason pattern 4 (poorly formed glands, fused glands, glomeruloid structures, and cribriform glands) have different prognostic implications . Recently published studies have shown that the cribriform pattern is associated with BCR, EPE, positive surgical margins, distant metastasis, and disease‐specific death . These studies suggest that the risk assessment of significant cancer should include the morphological subtype of Gleason pattern 4.…”

Section: Significant Prostate Cancer At Needle Biopsymentioning

confidence: 99%

Defining clinically significant prostate cancer on the basis of pathological findings

2018

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The definition of clinically significant prostate cancer is a dynamic process that was initiated many decades ago, when there was already evidence that a great proportion of patients with prostate cancer diagnosed at autopsy never had any clinical symptoms. Autopsy studies led to examinations of radical prostatectomy (RP) specimens and the establishment of the definition of significant cancer at RP: tumour volume of 0.5 cm3, Gleason grade 6 [Grade Group (GrG) 1], and organ‐confined disease. RP studies were then used to develop prediction models for significant cancer by the use of needle biopsies. The first such model was used to delineate the first active surveillance (AS) criteria, known as the ‘Epstein’ criteria, in which patients with a cancer Gleason score of 3 + 3 = 6 (GrG1) involving fewer than two cores, and <50% of any given core, and a prostate‐specific antigen density of <0.15 ng/ml per cm3 had a minimal risk of significant cancer at RP. These were adopted as components of the ‘very‐low‐risk category’ of the National Comprehensive Cancer Network guidelines, in which AS is supported as a management option. With the increase in the popularity of AS, much research has been carried out to better define significant/insignificant cancer, in order to be able to safely offer AS to a larger proportion of patients without the risk of undertreatment. Research has focused on allowing higher volume tumours, focal extraprostatic extension, and a limited amount of Gleason pattern 4, and the significance of different morphological patterns of Gleason 4. Other areas of research that will probably impact on the field but that are not covered in this review include the molecular classification of tumours and imaging techniques.

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Section: Significant Prostate Cancer At Needle Biopsymentioning

confidence: 99%

Defining clinically significant prostate cancer on the basis of pathological findings

2018

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“…Data on the prognostic significance of Paneth cell-like differentiation are still controversial. In fact, it seems to be correlated with favorable prognosis [29], although a positive correlation between Paneth cell-like change and cribriform pattern, which has been recently recommended as Gleason pattern 4 [30], has been also reported [28].…”

Section: Novel Morphologic Classificationmentioning

confidence: 99%

Neuroendocrine differentiation in prostate cancer: Novel morphological insights and future therapeutic perspectives

Santoni

Conti

Burattini

et al. 2014

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

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“…7,12,13 In 2005, the International Society of Urological Pathology (ISUP) assigned a Gleason grade 4 rather than Gleason grade 3 for a cribriform pattern. 8,9 In 2009, Lotan et al showed that there was often histologic continuity between glomeruloid glands and cribriform pattern. 14 Glomeruloid pattern is a term used to describe dilated glands containing intraluminal cribriform structures with a single point of attachment, reminiscent of a renal glomerulus.…”

Section: Cribriform Pattern In Invasive Prostate Cancermentioning

confidence: 99%

An updated review of cribriform carcinomas with emphasis on histopathological diagnosis and prognostic significance

Branca¹,

Ieni²,

Barresi³

et al. 2017

Oncol Rev

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Cribriform is a histopathological term used to describe a neoplastic epithelial proliferation in the form of large nests perforated by many quite rounded different-sized spaces. This growth pattern may be seen in carcinomas arising in different organs, and shows important prognostic implications. Therefore, recent data in literature suggest that cribriform carcinoma is a histologically and clinically distinctive type of tumour that should be separated from other similar tumour types. In this article, the pathology of cribriform adenocarcinoma of the prostate, lung, breast, stomach, colon, thyroid, and skin is discussed with particular reference to morphologic and immunohistochemical features, differential diagnosis, and clinical behaviour.

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Significance of the cribriform pattern in prostatic adenocarcinomas

Cited by 45 publications

References 11 publications

Defining clinically significant prostate cancer on the basis of pathological findings

Defining clinically significant prostate cancer on the basis of pathological findings

Neuroendocrine differentiation in prostate cancer: Novel morphological insights and future therapeutic perspectives

An updated review of cribriform carcinomas with emphasis on histopathological diagnosis and prognostic significance

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