Significance of TFF3 protein and Her-2/neu status in patients with gastric adenocarcinoma

Xu, Congcong; Lu, Yue; Wei, Hongjun; Zhao, Wenwen; Sui, Aihua; Wang, Xiumei; Qiu, Wensheng

doi:10.1016/j.prp.2013.04.017

Cited by 20 publications

(19 citation statements)

References 28 publications

(31 reference statements)

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“…TFF3 is inclined to be expressed in GC tissues with poorly differentiated or even undifferentiated type and diffuse type [24,57,87]. Accumulating studies have indicated that there were about a half of GCs showed a high level of TFF3 expression [24,51,62,77,87].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…Accumulating studies have indicated that there were about a half of GCs showed a high level of TFF3 expression [24,51,62,77,87]. One study reported that TFF3 was down-regulated in 16.7% of primary gastric carcinoma, and was up-regulated in 41.7% [76].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…One study reported that TFF3 was down-regulated in 16.7% of primary gastric carcinoma, and was up-regulated in 41.7% [76]. Moreover, in patients with early GCs, high expression of TFF3, is determined as an independent marker of poor prognosis [24,51,58,62,87]. Among the various variables, overexpression of TFF3 has a significant correlation with patient age only [62] and has no pronounced association with gender [56].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

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Trefoil factors: Gastrointestinal-specific proteins associated with gastric cancer

Xiao

Ling

Lan

et al. 2015

Clinica Chimica Acta

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Section: Accepted Manuscriptmentioning

confidence: 99%

Section: Accepted Manuscriptmentioning

confidence: 99%

Section: Accepted Manuscriptmentioning

confidence: 99%

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Trefoil factors: Gastrointestinal-specific proteins associated with gastric cancer

Xiao

Ling

Lan

et al. 2015

Clinica Chimica Acta

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“…TFF3 promotes mucosal wound healing in mice and humans [14–16]. The level of TFF3 mRNA expression has been associated with gastroadenocarcinoma progression [17] and biliary diseases [13, 18–20]. TFF3, which maps to the Obq4 obesity quantitative trait locus (QTL), was the most significantly changed of all genes analyzed.…”

Section: Introductionmentioning

confidence: 99%

Trefoil Factor 3 (TFF3) Is Regulated by Food Intake, Improves Glucose Tolerance and Induces Mucinous Metaplasia

Gardner

et al. 2015

PLoS ONE

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Trefoil factor 3 (TFF3), also called intestinal trefoil factor or Itf, is a 59 amino acid peptide found as a homodimer predominantly along the gastrointestinal tract and in serum. TFF3 expression is elevated during gastrointestinal adenoma progression and has been shown to promote mucosal wound healing. Here we show that in contrast to other trefoil factor family members, TFF1 and TFF2, TFF3 is highly expressed in mouse duodenum, jejunum and ileum and that its expression is regulated by food intake. Overexpression of TFF3 using a recombinant adeno-associated virus (AAV) vector, or daily administration of recombinant TFF3 protein in vivo improved glucose tolerance in a diet-induced obesity mouse model. Body weight, fasting insulin, triglyceride, cholesterol and leptin levels were not affected by TFF3 treatment. Induction of mucinous metaplasia was observed in mice with AAV-mediated TFF3 overexpression, however, no such adverse histological effect was seen after the administration of recombinant TFF3 protein. Altogether these results suggest that the therapeutic potential of targeting TFF3 to treat T2D may be limited.

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“…Based on the abovementioned knowledge, we hypothesized that NPM and TFF3 played a key role in carcinogenesis. It was recently demonstrated that there is a close association of human epidermal growth factor receptor 2 with NPM and TFF3 expression and that their co-expression may play a pivotal role in GC (22)(23). Furthermore, there is evidence demonstrating that NPM and TFF3 are involved in the regulation of apoptosis via the NF-κB signaling pathway, prompting us to determine the significance of their co-expression in GC.…”

Section: Introductionmentioning

confidence: 99%

Prognostic significance of the co-expression of nucleophosmin and trefoil factor 3 in postoperative gastric cancer patients

Yong

Sun

Liu

et al. 2014

Molecular and Clinical Oncology

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Abstract. Although a number of studies have indicated that the positive expression of nucleophosmin (NPM) and trefoil factor 3 (TFF3) is associated with oncogenesis and poor prognosis in several tumor types, the prognostic value of the co-expression of NPM and TFF3 in gastric cancer (GC) has not been fully elucidated. Therefore, in this study, we aimed to investigate the role of NPM and TFF3 in GC and determine their prognostic value. We retrospectively reviewed 108 patients who had undergone radical gastric tumor resection. The expression of NPM and TFF3 was detected by immunohistochemistry and the association of NPM and TFF3 with clinicopathological characteristics was investigated using the Chi-square test. Furthermore, univariate and multivariate analyses were conducted to determine the prognostic value of these markers. Of the 108 samples, NPM was positive in 57 (53%) and TFF3 was positive in 54 samples (50%). The positive expression of NPM was correlated with advanced tumor stage and recurrence (P=0.0333 and P<0.0001, respectively), whereas the expression of TFF3 was associated with larger tumor size (P=0.0005), poor differentiation (P=0.0435), lymph node metastasis (P=0.0116), advanced tumor stage (P=0.0244) and recurrence (P=0.0116). The univariate analysis revealed that the expression of NPM, the expression of TFF3 and the co-expression of the two were associated with poor survival (P=0.0004, 0.0028 and 0.0020, respectively). By multivariate analysis, all three factors were identified as independent prognostic factors in postoperative GC patients (hazard ratio = 1.970, 2.021 and 2.339, respectively). In conclusion, the expression of NPM and TFF3 and, particularly, the co-expression of the two, may serve as independent prognostic factors in postoperative GC patients.

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Significance of TFF3 protein and Her-2/neu status in patients with gastric adenocarcinoma

Cited by 20 publications

References 28 publications

Trefoil factors: Gastrointestinal-specific proteins associated with gastric cancer

Trefoil factors: Gastrointestinal-specific proteins associated with gastric cancer

Trefoil Factor 3 (TFF3) Is Regulated by Food Intake, Improves Glucose Tolerance and Induces Mucinous Metaplasia

Prognostic significance of the co-expression of nucleophosmin and trefoil factor 3 in postoperative gastric cancer patients

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