Significance of serum vascular endothelial growth factor, insulin-like growth factor-I levels and nitric oxide activity in breast cancer patients

Coşkun, Uğur; Günel, Nazan; Sancak, Banu; Günel, Uğur; Onuk, Erhan; Bayram, Orhan; Yı́lmaz, Erdal; Candan, Selamı; Özkan, Seçil

doi:10.1016/s0960-9776(02)00214-x

Cited by 33 publications

(33 citation statements)

References 35 publications

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“…We found increased VEGF in breast cancer patient with bone metastases, but not in patients with a localised disease, which is consistent with previous studies (Adams et al, 2000;Coskun et al, 2003). Increased VEGF level was also associated with biochemical markers of osteoclastic activity and bone matrix degradation, which is in agreement with a recent study showing high that VEGF stimulates osteoclastic differentiation in vitro (Aldridge et al, 2005).…”

Section: Discussionsupporting

confidence: 93%

“…Molecular factors regulating angiogenesis have been found also implicated in the regulation of tumour invasion (Kalebic et al, 1983). The number and density of microvessels in different human cancers was found associated with their invasive and metastatic potential (Kato et al, 2003) and have been shown to correlate with the serum concentrations of angiogenic factors such as the vascular endothelial growth factor (VEGF) (Coskun et al, 2003). High circulating levels of VEGF have been found to correlate with more advanced stages or with a worse prognosis in different tumours and in particular in women with breast cancer (Linderholm et al, 2000).…”

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confidence: 99%

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Association of 12 serum biochemical markers of angiogenesis, tumour invasion and bone turnover with bone metastases from breast cancer: a crossectional and longitudinal evaluation

Voorzanger-Rousselot¹,

Juillet²,

Mareau³

et al. 2006

Br J Cancer

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Complex biological pathways including angiogenesis, invasion, osteoclastic activation and bone matrix degradation are involved in the formation of bone metastasis (BM). The aim of our study was to investigate the cross-sectional and longitudinal associations of a panel of 12 serum biochemical markers reflecting biological pathways underlying BM development. In a cross-sectional study, we investigated 29 patients with primary breast carcinoma without BM (BC/BMÀ), 28 patients with breast carcinoma and BM (BC/ BM þ ) and 15 healthy women. In longitudinal analyses, we investigated 34 patients for whom serum was obtained a two different time points: at the time of primary BC diagnosis and after a median time of 3 years. During this follow-up, 15 patients developed BM, whereas the other 19 remained free of BM. In patients who developed BM, the second samples were obtained before BM was documented by bone scan. The cross-sectional analyses have shown all biochemical markers to be significantly elevated in patients with BM, when compared to the patients without BM and healthy controls, except TGFb1 that was significantly decreased. Multivariable analyses showed that only the bone resorption markers TRACP 5b, CTX and ICTP, and the marker of angiogenesis VEGF were independently associated with BM. Those markers correctly distinguished 85% of BC patients with or without BM from normal individuals. Longitudinal analyses showed that patients with primary BC who developed BM during follow-up had higher levels of TRACP5b ( þ 95%, P ¼ 0.08) at the time of primary diagnosis, those patients had also a higher increases of ICTP (P ¼ 0.006), MMP-7 (P ¼ 0.004) and TIMP-1 (P ¼ 0.017) during follow-up than patients who did not progress toward bone metastasis. This study provides evidence of increase and interrelationship of circulating markers of angiogenesis, invasion and bone resorption in patients with BC with and without BM. Markers of bone resorption have the highest independent diagnostic value for detecting and potentially predicting BM in breast carcinoma patients. Bone is one of the most common sites of metastasis for certain types of tumours, especially prostate, breast and lung carcinoma (Mundy, 2002). Breast cancer progression to bone is a defining feature of a highly malignant tumour and the major cause of cancer-treatment failure. Early detection of bone metastasis is critical for clinical management and accurate staging of tumours. Currently there is no a simple way to reliably detect and predict which patients will develop bone metastasis. The detection of bone metastases relies on imaging technology, but novel approaches based on biomarker assessments are under intense investigation. Increasing body of data suggests that metastatic dissemination is site specific (Horak and Steeg, 2005) and that distinct molecular factors regulate bone metastasis formation (Yin et al, 2005). A multifactorial and multistep process of bone metastasis formation involves several biological mechanisms including angiogenesis, invasion through...

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Section: Discussionsupporting

confidence: 93%

mentioning

confidence: 99%

Association of 12 serum biochemical markers of angiogenesis, tumour invasion and bone turnover with bone metastases from breast cancer: a crossectional and longitudinal evaluation

Voorzanger-Rousselot¹,

Juillet²,

Mareau³

et al. 2006

Br J Cancer

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“…Some of these studies have demonstrated that an elevated serum IGF-1 concentration was associated with an increased risk of breast cancer and other cancers in humans (9). Several authors have reported increased serum IGF-1 concentrations in breast cancer patients compared with healthy control (2,15). The positive correlation has been found between a high serum level of IGF-1 and advanced stage of breast cancer (2).…”

Section: Praca Oryginalnamentioning

confidence: 99%

“…IGF-1 is a potent mitogenic and anti-apoptotic agent (30), which is also involved in angiogenesis stimulation (2,20). Moreover, some studies suggest IGF-1 has a role in cell-cell adhesion and cell migration (28).…”

Section: Praca Oryginalnamentioning

confidence: 99%

“…Several authors have reported increased serum IGF-1 concentrations in breast cancer patients compared with healthy control (2,15). The positive correlation has been found between a high serum level of IGF-1 and advanced stage of breast cancer (2). Numerous in vitro and in vivo studies have shown that inhibition of IGF-1 signalling decreases tumour growth and metastasis (8).…”

Section: Praca Oryginalnamentioning

confidence: 99%

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Circulating concentrations of insulin like growth factor-1 in female dogs with spontane-ous mammary tumours

Szczubiał¹,

Dąbrowski²,

Łopuszyński³

et al. 2018

Medycyna Weterynaryjna

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SummaryThe aim of this study was the investigation of the circulating concentration of IGF-1 in female dogs with spontaneous mammary tumours. The study was performed on 34 female dogs undergoing surgery due to spontaneously occurring mammary gland tumours (24 malignant and 10 benign) and 10 clinically healthy female dogs. The serum concentrations of IGF-1 were determined by specific ELISA Kit assay. The mean concentrations of IGF-1 were significantly higher (P < 0.05) both in dogs with malignant (173.35 ± 120.45 ng/ml) and benign (130.58 ± 59.0 ng/ml) mammary tumours than in healthy controls (117.45 ± 71.0 ng/ml). In the group of female dogs with mammary carcinomas, the mean concentration of IGF-1 gradually increased from 132.85 ± 65.64 ng/ml in dogs with grade 1 tumours to 317.74 ± 119.25 ng/ml in those with grade 3 tumours, and significant differences (P < 0.05) were found among dogs with various grade tumours. These findings suggest that circulating IGF-1 may play an important role in the pathogenesis of canine mammary tumour. Moreover, high IGF-1 levels may reflect tumour cell differentiation into a more aggressive phenotype.

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Nitric oxide and metastatic cell behaviour

Williams

Djamgoz

2005

BioEssays

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Nitric oxide (NO) is a pleiotropic signalling molecule that subserves a wide variety of basic cellular functions and also manifests itself pathophysiologically. As regards cancer and its progression, however, the reported role of NO appears surprisingly inconsistent. In this review, we focus on metastasis, the process of cancer cell spread and secondary tumour formation. In a 'reductionist' approach, we consider the metastatic cascade to be made up of a series of basic cellular behaviours (such as proliferation, apoptosis, adhesion, secretion migration, invasion and angiogenesis). We evaluate how NO controls such behaviours, in comparison with normal cells. The available information suggests strongly that NO signalling would be expected to regulate these behaviours both positively and negatively and this probably leads to the observed apparent variability in the NO status of cancer cells and tissues. Thus, the role of NO in cancer is more complex than previously thought. A number of suggestions are made, including consideration of novel mechanisms, such as ion channels, in order to achieve a more consistent and integrated understanding of NO signalling in cancer and to realise its clinical potential.

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Significance of serum vascular endothelial growth factor, insulin-like growth factor-I levels and nitric oxide activity in breast cancer patients

Cited by 33 publications

References 35 publications

Association of 12 serum biochemical markers of angiogenesis, tumour invasion and bone turnover with bone metastases from breast cancer: a crossectional and longitudinal evaluation

Association of 12 serum biochemical markers of angiogenesis, tumour invasion and bone turnover with bone metastases from breast cancer: a crossectional and longitudinal evaluation

Circulating concentrations of insulin like growth factor-1 in female dogs with spontane-ous mammary tumours

Nitric oxide and metastatic cell behaviour

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