Significance of serum ferritin level in the prediction of delivery of low birth weight newborns for gestational age

Abstract

Based on the level of ferritin and other parameters in the period of 30-32 weeks of gestation, we can predict pregnant women in whom we can expect development of intrauterine growth restriction.

Role of Maternal Serum Ferritin in the Prediction of Asymmetric Intrauterine Growth Restriction

“…The value of maternal serum ferritin in predicting asymmetric IUGR was previously investigated, for few times, on small numbers of cases, i.e. 7 cases in Ozgu-Erdinc et al [9] , 18 cases in Milasinovic et al [13] , 10 cases in Hubel et al [14] , 17 cases in Visnjevac et al [15] , and 31 cases in Bindal et al, [16] or with limitations in the research methodology such as measuring ferritin at a gestational age that was to early (20 weeks) or to late (36 weeks) [1,4] , or including cases with maternal iron deficiency anemia [15] .…”

“…[22] Hou et al, Milasinovic et al and Višnjevac et al identified the ferritin threshold to predict IUGR or SGA as >13.6 ng/ml. [4,13,15] Ozgu et al reported maternal serum ferritin levels >60 ng/ml to increase the risk for IUGR. [9] Bindal et al concluded that maternal serum ferritin >20 ng/ml predicted IUGR with an odds ratio of 6.6.…”

“…[11] Ferritin blood level normally drops, in correlation with the progressive depletion of iron reserves, by 32% during the first trimester, 39% in the second and up to 53% during the third trimester. [12] This level reaches a nadir at 30-32 weeks, [13] after which it stays constant.…”

“…IUGR relies on decreased placental extraction of ferritin from the systemic circulation. [13] Its predictive value was previously investigated, in a few small-sized studies, on a small number of cases. [9,[13][14][15][16] This study aimed to assess the accuracy of maternal serum ferritin level at 30 weeks to 32 weeks in predicting the development of IUGR and to identify the ferritin cutoff level with the best predictive value, in a well-selected, adequate-sized group of pregnant women.…”

A relação entre as concentrações de hemoglobina durante a gravidez e peso de nascimento / The relationship between hemoglobin concentrations during pregnancy and birth weight

“…In the present study, the following cutoff points for maternal Hb were set in relation to the occurrence of LBW: 12.6 g/dL (1st trimester), 11.4 g/dL (2nd trimester), and 12.35 g/dL (3rd trimester). Milasinović et al (28) found that pregnant women with Hb values > 11.7 g/dL and ferritin concentrations above 13.6 ng/mL and hematocrit > 32.9% in the 30th to 32nd week of pregnancy were more likely to have restricted intrauterine growth and LBW infants, according to the analysis of the ROC curve. Their proposed cut-off point for Hb was similar to that found in the second trimester of pregnancy (11.4 stages, the production of red blood cells is compromised, and anemia can be detected by hemoglobin concentrations (≤ 11 g/dL in the first and third quarters and ≤ 10.5 g/dL in the second quarter) (30).…”