Significance of serum and tissue carcinoembryonic antigen for the prognosis of gastric carcinoma patients

Kim, Dong Yi; Kim, Hyeong Rok; Shim, Jae Hoon; Park, Chang Soo; Kim, Shin Kon; Kim, Young Jin

doi:10.1002/1096-9098(200007)74:3<185::aid-jso4>3.0.co;2-0

Cited by 53 publications

(38 citation statements)

References 29 publications

(42 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…CEA is also well known as a tumour marker in gastric cancer. It has been reported that serum levels and tissue expression of this protein correlate with evidence of tumour progression, such as lymph node metastasis, in keeping with our results (Kojima et al, 1984;Nakane et al, 1994;Kim et al, 2000). Nonspecific crossreacting antigen is a member of the CEA family …”

Section: Discussionsupporting

confidence: 92%

Gene expression profiles in human gastric cancer: expression of maspin correlates with lymph node metastasis

et al. 2005

View full text Add to dashboard Cite

To seek for a candidate gene that would regulate tumour progression and metastasis in gastric cancer, we investigated gene expression profiles by using DNA microarray. Tumour tissue and adjacent normal tissue were obtained from 21 patients with gastric cancer and then examined for their gene expression profiles by the Gene Chip s Human U95Av2 array, which includes 12 000 human genes and EST sequences. A total of 25 genes were upregulated and two genes were downregulated by at least four-fold in the tumour tissue. In a further analysis according to lymph node metastasis, the expressed levels of maspin, as well as carcinoembryonic antigen and nonspecific crossreacting antigen were significantly higher in tumours with lymph node metastasis than in those without it. Maspin expression in 85 gastric cancer patients was further investigated by using immunohistochemistry. Maspin expression was not observed in normal gastric epithelia without intestinal metaplasia. In contrast, maspin was expressed in 74 of 85 tumour tissues. There was a significant correlation between the incidence of maspin-positive tumour staining and lymph node metastasis. These results suggest that maspin has a potential role for tumour metastasis in gastric cancer.

show abstract

Section: Discussionsupporting

confidence: 92%

Gene expression profiles in human gastric cancer: expression of maspin correlates with lymph node metastasis

et al. 2005

View full text Add to dashboard Cite

show abstract

“…Originally named for their transforming activities in in vitro assays, TGF-bs now unequivocally demonstrate both tumor suppressor and oncogenic activities. In the current paradigm, the suppressor activities dominate in normal tissue, but during tumorigenesis, changes in TGF-b expression and cellular responses tip the balance in favor of its oncogenic activities (Kim DY et al, 2000;Kim S-J et al, 2000;Wakefield and Roberts, 2002).…”

Section: Discussionmentioning

confidence: 99%

“…CEAs are widely used clinically as tumor markers, specifically for the detection of colorectal carcinoma after surgical resection (Chevinsky, 1991). Many different types of tumors (about 50% of all human tumors) show overexpression of CEAs (Chevinsky, 1991;Kim DY et al, 2000;Kim S-J et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

CEACAM5 and CEACAM6 are major target genes for Smad3-mediated TGF-β signaling

et al. 2007

View full text Add to dashboard Cite

The carcinoembryonic antigen (CEAs) family consists of a large group of evolutionarily and structurally divergent glycoproteins. The transforming growth factor-b (TGF-b) signaling pathway has been implicated in the stimulation of CEA secretion in TGF-b-sensitive colon cells, thereby possibly modulating cell adhesion and differentiation. However, the specific CEAs targeted by TGF-b signaling or underlying mechanism of the expression of CEAs has not yet been clarified. In this study, we investigated the specific CEAs targeted by the TGF-b signaling pathway. In nine human gastric cancer cell lines examined, TGF-bresponsive cell lines showed positive expression of CEAs. Expression patterns of CEA proteins correlated well with the level of CEA (CEACAM5) and CEACAM6 transcripts in these cell lines, but CEACAM1 expression was not observed in all of these cells. To investigate the role of TGF-b signaling in CEA expression, we selected two TGFb unresponsive gastric cancer cell lines; SNU638 cells that contain a mutation in the TGF-b type II receptor and SNU484 cells that express low to undetectable level of the TGF-b pathway intermediate protein, Smad3. Restoration of TGF-b signaling in these cells induced expression of the CEAs and increased activity of both CEA (CEACAM5) and CEACAM6 promoters. CEA expression was observed in the epithelium of the stomach of wild-type mice, but was markedly decreased in Smad3 null mice. These findings suggest that CEA (CEACAM5) and CEACAM6 are major target genes for Smad3-mediated TGF-b signaling.

show abstract

“…CEA was strongly associated with the T factor [29,30,33,37], [11] analyzed 68 patients with stage IV gastric cancer using multivariate analysis and concluded that an elevated CEA level was an independent risk factor for predicting liver metastases. A few reports have shown a significant association between elevated CEA and peritoneal metastases [18,34].…”

Section: Ceamentioning

confidence: 99%

“…A few reports have shown a significant association between elevated CEA and peritoneal metastases [18,34]. Although several reports showed that elevated CEA was significantly associated with differentiated tumor types [7,10,48,61], a few reports indicated an association with poorly differentiated types of tumors [29]. Maehara et al analyzed the CEA levels in 221 patients with welldifferentiated gastric cancer.…”

Section: Ceamentioning

confidence: 99%

Clinical significance of serum tumor markers for gastric cancer: a systematic review of literature by the Task Force of the Japanese Gastric Cancer Association

et al. 2013

View full text Add to dashboard Cite

The aim of this review was to evaluate the clinical significance of serum tumor markers, particularly CEA, CA19-9, and CA72-4, in patients with gastric cancer. A systematic literature search was performed using PubMed/MEDLINE with the keywords ''gastric cancer'' and ''tumor marker,'' to select 4,925 relevant reports published before the end of November 2012. A total of 187 publications contained data for CEA and CA19-9, and 19 publications contained data related to all three tumor markers. The positive rates were 21.1 % for CEA, 27.8 % for CA19-9, and 30.0 % for CA72-4. These three markers were significantly associated with tumor stage and patient survival. Serum markers are not useful for early cancer, but they are useful for detecting recurrence and distant metastasis, predicting patient survival, and monitoring after surgery.

show abstract

Significance of serum and tissue carcinoembryonic antigen for the prognosis of gastric carcinoma patients

Abstract: These data suggest that preoperative serum CEA levels and staining for CEA in gastric carcinoma tissue sections may have a predictive value in determining prognostic information for patients with resectable gastric carcinoma.

Cited by 53 publications

References 29 publications

Gene expression profiles in human gastric cancer: expression of maspin correlates with lymph node metastasis

Gene expression profiles in human gastric cancer: expression of maspin correlates with lymph node metastasis

CEACAM5 and CEACAM6 are major target genes for Smad3-mediated TGF-β signaling

Clinical significance of serum tumor markers for gastric cancer: a systematic review of literature by the Task Force of the Japanese Gastric Cancer Association

Contact Info

Product

Resources

About