Significance of self-reported sleep quality (SQ) in chronic kidney disease (CKD): the Renal Research Institute (RRI)-CKD study

Kumar, BK Shiva; Tilea, Anca; Gillespie, B.W.; Zhang, X; Kiser, Margaret; Eisele, George; Finkelstein, Fredric O.; Kotanko, Peter; Levin, N.W.; Rajagopalan, Srini; Saran, Rajiv

doi:10.5414/cnp73104

Cited by 42 publications

(54 citation statements)

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“…Poor sleep quality has been associated with an increased risk of mortality in pre-ESRD and hemodialysis patients [3] [14]. We did not find a significant correlation between SQ and mortality, perhaps due to the fact that our study population has less cardiovascular comorbid conditions than patients on dialysis or pre-dialysis.…”

Section: Discussioncontrasting

confidence: 47%

“…Other confounding factors, such as education, marital state and employment status may also influence on SQ differences between genders. Association of SQ and renal function is controversial [9] [13] [14]. We observed a correlation between impairment of sleep and renal function using calculated eGFR (and not serum creatinine) as measure of renal dysfunction.…”

Section: Discussionmentioning

confidence: 65%

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Sleep Quality in Non Dialysis Chronic Kidney Disease: Associated Factors and Influence on Prognosis

Calviño¹,

González-Tabarés²,

Cigarrán³

et al. 2016

IJCM

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Deficient sleep quality (SQ) has been linked with a higher hospitalization rate and mortality in dialysis patients, however the prevalence of sleep disorders and their influence on prognosis in non-dialysis chronic kidney disease (CKD) has been poorly investigated. The aim of this study was to assess factors related with SQ in CKD patients (stages I-IV) followed in a nephrology outpatient clinic as well as the long-term impact of SQ on patient's outcome. Between January and May 2008, Pittsburgh Sleep Quality Index (PSQI) was self-administered by 122 patients (68 males and 54 females) with a mean age of 65 years. Patients were classified as "good" (global PSQI < 6) and "poor" sleepers (global PSQI ≥ 6). We identified 66 (54%) poor sleepers (PS), characterized by an older age (66 ± 14.2 vs 57 ± 17.0, p < 0.01), female predominance (59% vs 26%, p < 0.01) and worse renal function (49 ± 19.1 vs 57 ± 23.2 ml/min, p < 0.05). There was a significant correlation between phosphate and PSQI score (r = 0.234, p = 0.01), however no correlation with calcium or PTH. Vitamin D was also lower in PS (17 ± 7.2 vs 23 ± 15.1 ng/ml, p < 0.05). Until June 2015, hospitalization rate was higher among PS (64% vs 44%, p < 0.05). In this period, there was also a trend towards higher mortality for PS (18% vs 16%). In summary, over 50% of CKD patients have poor SQ, which was associated with older age, female gender, worse renal function, lower vitamin D and higher phosphate levels. Deficient sleep was associated with a greater probability of hospitalization and might be a prognostic marker in CKD.

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Section: Discussioncontrasting

confidence: 47%

Section: Discussionmentioning

confidence: 65%

Sleep Quality in Non Dialysis Chronic Kidney Disease: Associated Factors and Influence on Prognosis

Calviño¹,

González-Tabarés²,

Cigarrán³

et al. 2016

IJCM

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“…Poor quality of sleep is an important factor to be considered in this group as this has been found to worsen the quality of life [3,25]. The available literature shows that a variety of factors are associated with poor sleep quality, e.g., young age, older age, depression, reduced appetite, diabetes, body pain, sedentary life, body mass index, waist circumference, dyspnea, and sleep apnea to name a few [3,10,12,23,26,27].…”

Section: Discussionmentioning

confidence: 99%

“…Some studies have reported that increasing duration of dialysis, physical health, co-morbidities, burden of kidney disease, sexual function, dyspnea, pain, itching, mean corpuscular volume, serum albumin, and diabetes mellitus worsen the quality of sleep [2,3,9,10]. However, contradictory studies are also available that suggest that quality of sleep in MHD patients is not related to age, gender, biochemical parameters, and other factors mentioned above [4,6].…”

Section: Introductionmentioning

confidence: 99%

“…However, one study did not find any correlation between the mortality and poor sleep among these patients [13]. Not only the mortality but the morbidity is also important and poor quality of life has been consistently reported in patients on MHD with poor quality of sleep [4,10,12,14]. Moreover, patients with poor quality of sleep are also prone to consume a number of medications, e.g., hypnotics, antidepressants, antihistaminics, and narcotics [12].…”

Section: Introductionmentioning

confidence: 99%

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Prevalence and Predictors of Poor Sleep Quality in Patients on Maintenance Hemodialysis

2017

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Purpose Majority of patients on maintenance hemodialysis complain of poor quality of sleep. Earlier studies show controversial findings with regard to the prevalence and predictors of poor quality of sleep in this group. Hence, the present study was planned. Methods Adult subjects undergoing maintenance hemodialysis were included in this study. Their demographic data, history regarding chronic kidney disease, comorbidities, and details related to hemodialysis were recorded. Sleep quality was assessed using Pittsburg Sleep Quality Index. A total of 201 patients were included in this study. Results Average age of the subjects was 54.7 ± 15.1 years and duration of kidney disease was 37.1 ± 19.8 years. 40.3% subjects were women and 50.7% of sample complained of poor quality sleep. Poor sleepers had less than 3/week dialysis (68.6% among poor sleepers vs. 21.2% among good sleepers; P \ 0.001), nighttime dialysis shift (52.9 vs. 20.2% among good sleepers; P \ 0.001), diabetes mellitus (56.9 vs. 39.4% among good sleepers; P = 0.01), and hypnotic use (P \ 0.001). Similarly, subjects with poor sleep quality were older (57.3 ± 14.3 vs. 52.1 ± 15.4 years among good sleepers; P = 0.01). Binomial logistic regression showed that less than thrice a week dialysis and schedule of maintenance hemodialysis predicted the poor sleep quality. Less than 3/week dialysis increased the odds for poor sleep by 6.6 (P \ 0.001) and afternoon and nighttime maintenance hemodialysis shift by 3.2 (P \ 0.001) and 4.6 (P \ 0.001), respectively. Conclusion Poor sleep is a common complaint in patients on hemodialysis. We found that the evening or night shift of hemodialysis and twice weekly hemodialysis worsened the quality of sleep.

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Interventions for improving sleep quality in people with chronic kidney disease

Natale¹,

Ruospo²,

Saglimbene

et al. 2017

Cochrane Database of Systematic Reviews

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Significance of self-reported sleep quality (SQ) in chronic kidney disease (CKD): the Renal Research Institute (RRI)-CKD study

Cited by 42 publications

References 0 publications

Sleep Quality in Non Dialysis Chronic Kidney Disease: Associated Factors and Influence on Prognosis

Sleep Quality in Non Dialysis Chronic Kidney Disease: Associated Factors and Influence on Prognosis

Prevalence and Predictors of Poor Sleep Quality in Patients on Maintenance Hemodialysis

Interventions for improving sleep quality in people with chronic kidney disease

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