Significance of <scp>C</scp>harcot <scp>L</scp>eyden crystals in liver cytology—A case report

Thakral, Divya Arora; Agarwal, Pallavi; Saran, Ravindra Kumar; Saluja, Sundeep Singh

doi:10.1002/dc.23228

Cited by 10 publications

(6 citation statements)

References 4 publications

(13 reference statements)

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“…As early as 1947, Samter stated that "numerous observations have established the relation between the presence of disintegrating eosinophilic leukocytes and Charcot-Leyden crystals" [2]. CLCs have been repeatedly described in association with "necrotic" or "damaged" cells ( [21][22][23][24][25], Table 1). In addition, the presence of CLCs in nasal polyps from patients with eosinophilic chronic rhinosinusitis was associated with disease severity [26••].…”

Section: Pathological Features Of Clcsmentioning

confidence: 99%

Charcot-Leyden Crystals in Eosinophilic Inflammation: Active Cytolysis Leads to Crystal Formation

Ueki

Miyabe

Yamamoto

et al. 2019

Curr Allergy Asthma Rep

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Purpose of Review-Charcot-Leyden crystals (CLCs), slender bipyramidal hexagonal crystals, were first described by Jean-Martin Charcot in 1853, predating Paul Ehrlich's "discovery" of eosinophils by 26 years. To date, CLCs are known as a classical hallmark of eosinophilic inflammation. CLC protein expresses palmitate cleaving lysophospholipase activity and is a member of the family of S-type lectins, galectin-10. We summarize current knowledge regarding the pathological observations of CLCs and their mechanism of generation focusing on eosinophil cell death. Recent Findings-The presence of CLCs in vivo has been consistently associated with lytic eosinophils. Recent evidence revealed that cytolysis represents the occurrence of extracellular trap cell death (ETosis), an active non-apoptotic cell death process releasing filamentous chromatin structure. Galectin-10 is a predominant protein present within the cytoplasm of eosinophils but not stored in secretory granules. Activated eosinophils undergo ETosis and loss of galectin-10 cytoplasmic localization results in intracellular CLC formation. Free galectin-10 released following plasma membrane disintegration forms extracellular CLCs. Of interest, galectin-10containing extracellular vesicles are also released during ETosis. Mice models indicated that CLCs could be a novel therapeutic target for Th2-type airway inflammation.

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Section: Pathological Features Of Clcsmentioning

confidence: 99%

Charcot-Leyden Crystals in Eosinophilic Inflammation: Active Cytolysis Leads to Crystal Formation

Ueki

Miyabe

Yamamoto

et al. 2019

Curr Allergy Asthma Rep

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“…Although Charcot-Leyden crystals were not observed in this case, about half of the cases of VLM have diamond-shaped crystals that stain red with the growth of collagen fibers that crystallize after degranulation of eosinophil granules. This is a useful characteristic finding ( 30 , 31 ).…”

Section: Discussionmentioning

confidence: 89%

Eosinophilic Granuloma of the Liver Mimicking Metastatic Liver Tumor

et al. 2022

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We herein report a case of coagulation necrosis with granulation and eosinophilic infiltration of the liver. A 37-year-old woman was diagnosed with a new mass lesion in the liver 1 month after breast cancer surgery and admitted for a further examination. Because the tumor occurred immediately after surgery, it was considered essential to determine whether or not it was a metastatic liver tumor from breast cancer. A percutaneous liver tumor biopsy revealed eosinophilic granuloma of the liver, which is considered to have a high possibility of visceral larva migrans with suspected gnathostomiasis infection. A detailed medical history and histological diagnosis are important for making a differential diagnosis.

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“…CLC/Gal-10 has been found at sites of infection mediated by helminths [152], fungi [153,154] and bacteria [155]. Interestingly, CLC/Gal-10 has been reported to be downregulated at mRNA gene expression level in patients with respiratory syncytial virus (RSV) infection [156].…”

Section: Function and Clinical Relevance Of Eosinophil-derived Granule Proteins Cytokines And Chemokinesmentioning

confidence: 99%

The Enigma of Eosinophil Degranulation

Fettrelet

Gigon

Karaulov

et al. 2021

IJMS

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Eosinophils are specialized white blood cells, which are involved in the pathology of diverse allergic and nonallergic inflammatory diseases. Eosinophils are traditionally known as cytotoxic effector cells but have been suggested to additionally play a role in immunomodulation and maintenance of homeostasis. The exact role of these granule-containing leukocytes in health and diseases is still a matter of debate. Degranulation is one of the key effector functions of eosinophils in response to diverse stimuli. The different degranulation patterns occurring in eosinophils (piecemeal degranulation, exocytosis and cytolysis) have been extensively studied in the last few years. However, the exact mechanism of the diverse degranulation types remains unknown and is still under investigation. In this review, we focus on recent findings and highlight the diversity of stimulation and methods used to evaluate eosinophil degranulation.

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Significance of Charcot Leyden crystals in liver cytology—A case report

Cited by 10 publications

References 4 publications

Charcot-Leyden Crystals in Eosinophilic Inflammation: Active Cytolysis Leads to Crystal Formation

Charcot-Leyden Crystals in Eosinophilic Inflammation: Active Cytolysis Leads to Crystal Formation

Eosinophilic Granuloma of the Liver Mimicking Metastatic Liver Tumor

The Enigma of Eosinophil Degranulation

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