Significance of retropharyngeal nodes in cancer of the head and neck

Ballantyne, Alando J.

doi:10.1016/0002-9610(64)90143-6

Cited by 132 publications

(65 citation statements)

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“…This is well within the reported range of 16-50% published in previous studies [7,8,10,15]. We found that advanced T stage cancer (T3 -T4) have significantly higher odds of being RPLN positive by PET-CT scan.…”

Section: Discussionsupporting

confidence: 92%

PET‐CT Staging of the Neck in Cancers of the Oropharynx: Patterns of Regional and Retropharyngeal Nodal Metastasis

et al. 2010

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Objective: To study the retropharyngeal lymph node status (RPLN) by pretreatment PET-CT imaging in patients with squamous cell carcinomas of the oropharynx (OPSCC). Study Design: Retrospective.Methods: 101 patients with a biopsy proven OPSCC were identified. 53 patients meeting inclusion criteria were further analyzed. Conclusions: Pre-treatment PET-CT can be used as a staging tool to aid in treatment planning of OPSCC, as rates of RPLN and nodal metastasis are consistent with those reported in the literature. Advanced T and N stage are associated with a greater odds ratio of being RPLN positive by PET-CT imaging.

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Section: Discussionsupporting

confidence: 92%

PET‐CT Staging of the Neck in Cancers of the Oropharynx: Patterns of Regional and Retropharyngeal Nodal Metastasis

et al. 2010

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“…Since Ballantyne reported that RPLN metastases is associated with poor prognosis in patients with pharyngeal wall cancer [7], several reports have suggested that the control of neck metastases, distant metastases, and survival rates are significantly associated with RPLN metastases [1,[7][8][9][10] RPLNs are considered to act as the first echelon of lymphatic drainage for the nasopharynx, paranasal sinuses, oropharynx and hypopharynx [7,12,13]. Metastatic involvement of the lateral retropharyngeal nodes may lead to secondary invasion and compression of the carotid sheaths [14].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Ballantyne conducted a retrospective study of 34 patients with SCC of the pharyngeal wall. Metastasis to the RPLNs was detected by microscopic examination in 15 (44.1 %) of the 34 patients, and RPLN involvement was associated with a significantly poorer survival rate [7]. McLaughlin et al found the overall incidence of radiologically positive RPLN among 774 patients with SCC of the nasopharynx, oropharynx, hypopharynx, or supraglottis to be 9% [1].…”

Section: Discussionmentioning

confidence: 99%

“…RPLNs are considered to act as the first echelon of lymphatic drainage for the nasopharynx, paranasal sinuses, oropharynx and hypopharynx [7,12,13]. Metastatic involvement of the lateral retropharyngeal nodes may lead to secondary invasion and compression of the carotid sheaths [14].…”

Section: Discussionmentioning

confidence: 99%

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Effectiveness of superselective intra-arterial chemoradiotherapy targeting retropharyngeal lymph node metastasis

Suzuki

Sakashita

Homma

et al. 2016

Eur Arch Otorhinolaryngol

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Objective. We sought to evaluate the efficacy and feasibility of superselective intra-arterial infusion of high-dose cisplatin with concomitant radiotherapy (hereafter RADPLAT) for head and neck squamous cell cancer (hereafter HNSCC) patients with retropharyngeal lymph node (hereafter RPLN) metastasis. Study Design. Retrospective case series reviewSetting. University medical center in Japan Subjects and Methods. Ten HNSCC patients with RPLN metastasis treated by RADPLAT were analyzed.Results. The ascending pharyngeal artery was targeted for the treatment of RPLN metastasis in 9 patients. The median total dose of cisplatin was 26.6 mg/m2 (mean, 31.5 mg/m2; range, 11.7-87.9 mg/m2). In the remaining patient, the RPLN was supplied by the ascending palatine artery. As grade 3 and 4 adverse effects, leukopenia was observed in three, mucositis in four and nausea in one patient. No neurological complications were observed in any patients. Metastatic RPLNs were evaluated as a complete response in all patients. There was no recurrence of RPLN metastasis in any patients. Four patients remain alive without any evidence of disease and six patients died of disease. The 5-year overall survival rate was 50%.Conclusions. We have shown that superselective intra-arterial cisplatin infusion for RPLNs was a feasible and 2 effective approach for HNSCC patients with RPLN metastasis. INTRODUCTIONRetropharyngeal lymph node (RPLN) metastasis is considered to be a significant predictor of poor prognosis for patients with head and neck squamous cell carcinomas (HNSCCs) [1,2]. RPLN dissection is relatively simple and takes only a few minutes when performed electively. On the other hand, gross involvement of the RPLNs by the tumor can make the operation difficult and, at times, not feasible [3].Recently, superselective intra-arterial chemotherapy in combination with concomitant radiotherapy (RADPLAT) has been performed for patients with locally advanced HNSCC and has been reported to result in a favorable outcome, preserving function and improving survival [4,5]. We considered RADPLAT to be applicable to the treatment of RPLN metastasis and, therefore, assessed the efficacy and feasibility of this non-surgical treatment for HNSCC patients with RPLN metastasis. MATERIALS AND METHODSPatients. Two hundred thirty-five patients with untreated HNSCCs underwent RADPLAT in Hokkaido University Hospital, Japan between September 1999 and July 2012. In this study, we analyzed ten patients who 3 had RPLN metastasis. The primary tumor sites were the hypopharynx in six, the maxillary sinus in two, and the oropharynx in two patients. Eight patients were diagnosed with Stage IVA, one with Stage IVB, the remaining patient with stage III. Other detailed characteristics are shown in Table 1 Cisplatin infusion mainly targeted the primary tumor, RPLNs and sometimes metastatic lymph nodes. At the same time, sodium thiosulfate (20-24 g) was given intravenously to neutralize cisplatin toxicity [6]. All arterial catheterizations were accomplished transcutaneo...

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Selective Neck Dissection of Anatomically Appropriate Levels Is as Efficacious as Modified Radical Neck Dissection for Elective Treatment of the Clinically Negative Neck in Patients With Squamous Cell Carcinoma of the Upper Respiratory and Digestive Tracts

Clayman¹,

Frank²

1998

Arch Otolaryngol Head Neck Surg

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Significance of retropharyngeal nodes in cancer of the head and neck

Cited by 132 publications

References 0 publications

PET‐CT Staging of the Neck in Cancers of the Oropharynx: Patterns of Regional and Retropharyngeal Nodal Metastasis

PET‐CT Staging of the Neck in Cancers of the Oropharynx: Patterns of Regional and Retropharyngeal Nodal Metastasis

Effectiveness of superselective intra-arterial chemoradiotherapy targeting retropharyngeal lymph node metastasis

Selective Neck Dissection of Anatomically Appropriate Levels Is as Efficacious as Modified Radical Neck Dissection for Elective Treatment of the Clinically Negative Neck in Patients With Squamous Cell Carcinoma of the Upper Respiratory and Digestive Tracts

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